التفاصيل البيبلوغرافية
| العنوان: |
Temporal trends of acute kidney injury in patients undergoing percutaneous coronary intervention over a span of 12 years. |
| المؤلفون: |
Skalsky, Keren1 (AUTHOR) kerens@clalit.org.il, Shiyovich, Arthur1 (AUTHOR), Bental, Tamir1 (AUTHOR), Vaknin-Assa, Hana1 (AUTHOR), Assali, Abid1,2 (AUTHOR), Gal, Tuvia Ben1 (AUTHOR), Avraham, Binyamin Ben1 (AUTHOR), Eisen, Alon1 (AUTHOR), Steinmetz, Tali1,3 (AUTHOR), Kornowski, Ran1 (AUTHOR), Perl, Leor1 (AUTHOR) |
| المصدر: |
International Journal of Cardiology. Mar2021, Vol. 326, p44-48. 5p. |
| مصطلحات موضوعية: |
*ACUTE kidney failure, *PERCUTANEOUS coronary intervention, *PERIPHERAL vascular diseases, *GENDER, *MEDICAL registries |
| مستخلص: |
AKI is a known complication of PCI and is associated with higher rates of adverse events. We assessed temporal trends in rates of AKI, factors associated with risk of AKI and prognosis. From a prospective registry of patients undergoing PCI at two hospitals of the Rabin Medical Center, 15,153 consecutive patients were assessed at two time periods: 2006–2012 and 2012–2018. AKI was defined as either a relative elevation of ≥25% in serum creatinine or an absolute elevation of ≥0.5 mg/dl in serum creatinine at 48 h post PCI. Data for 7913 patients from 2006 to 2012 and 7240 during 2012–2018 was available for analysis. Mean age was 65.0 ± 11.9y and 66.0 ± 12.3y (p < 0.001) and baseline creatinine was 1.08 ± 0.87 mg/dl and 1.15 ± 0.97 mg/dl, respectively (p < 0.001). Rates of AKI were 11.1% in the early and 7.3% in the late period (p < 0.001). Following adjustment, risk of AKI was lower in the late period (OR- 0.72; 95% CI 0.61–0.85, p < 0.001). AKI was associated with increased MACE (HR 1.62; 95% CI 1.44–1.82, p < 0.001 for the early period and HR 2.11; 95% CI 1.80–2.46, P < 0.001 for the late period) and death (HR 1.86; 95% CI 1.64–2.11, p < 0.001; HR 2.4; 95% CI 2.02–2.86; p < 0.001) in both time periods. Over time, there was an improvement in the rates of post-PCI AKI. Increased adverse outcomes were evident at both periods. Further research is warranted, to further reduce peri-procedural AKI which is associated with impaired prognosis. • Acute kidney injury (AKI) is a known complication of percutaneous coronary intervention (PCI). • The rates of AKI post PCI has decreased from 11.1% between the years 2006–2012 to 7.3% in 2012–2018. • Associated risk factors include female gender, advanced age heart failure and peripheral vascular disease. • AKI was associated with increased MACE and death in both time periods. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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