التفاصيل البيبلوغرافية
| العنوان: |
Retrospective Review of Norethindrone Use in Adolescents. |
| المؤلفون: |
Santos, M.1 xmsantos@texaschildrens.org, Hendry, Deborah1, Sangi-Haghpeykar, Haleh1, Dietrich, Jennifer E.1 |
| المصدر: |
Journal of Pediatric & Adolescent Gynecology. Feb2014, Vol. 27 Issue 1, p41-44. 4p. |
| مصطلحات موضوعية: |
*NORETHINDRONE, *DRUG utilization, *MENSTRUAL cycle, *TERTIARY care, *MEDICAL centers, *DRUG efficacy, *LONGITUDINAL method, *RETROSPECTIVE studies, DISEASES in adults |
| مستخلص: |
Abstract: Study Objective: Our objectives were to review norethindrone use in an adolescent population in a tertiary care center and to assess the effectiveness of the norethindrone taper in the management of acute heavy menstrual bleeding in adolescents. Design: Retrospective cohort study. Setting: Tertiary care center. Participants: 176 adolescent females prescribed norethindrone 0.35 mg between July 2007 and September 2010. Interventions: None. Main Outcome Measures: Discontinuation and irregular bleeding rates. Results: Mean age was 14.8 ± 2.3 years. Most common indication for use was heavy menstrual bleeding (32.9%). Most common reasons for use of a progestin only pill were neurologic (27.8%) and cardiovascular diseases (17.6%). Discontinuation rate was 48.5%, most commonly for irregular bleeding (54.5%). Irregular bleeding and systemic side effects were associated with discontinuation (P = .006 and .003 respectively). No serious adverse events were reported. Twenty patients required norethindrone taper for heavy bleeding; of this group 78.9% experienced complete cessation of bleeding within 7 days. Conclusions: Our findings support use of norethindrone as an effective alternative among adolescents with contraindications to administration of estrogen and for whom control of acute heavy menstrual bleeding is desired. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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