دورية أكاديمية
Admission of tetanus patients to the ICU: a retrospective multicentre study
| العنوان: | Admission of tetanus patients to the ICU: a retrospective multicentre study |
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| المؤلفون: | Mahieu, Rafael, Reydel, Thomas, Maamar, Adel, Tadié, Jean-Marc, Jamet, Angeline, Thille, Arnaud, Chudeau, Nicolas, Huntzinger, Julien, Grange, Steven, Beduneau, Gaetan, Ehrmann, Stephan, Courte, Anne, Lemarié, Jérémie, Gibot, Sebastien, Darmon, Michaël, Guitton, Christophe, Champey, Julia, Schwebel, Carole, Dellamonica, Jean, Wipf, Thibaut, Meziani, Ferhat, Du Cheyron, Damien, Kouatchet, Achille, Lerolle, Nicolas |
| المساهمون: | ATOMycA (CRCINA-ÉQUIPE 6), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Université de Rennes - Faculté de Médecine (UR Médecine), Université de Rennes (UR), Etablissement français du sang Rennes (EFS Bretagne), Institut Mondor de recherche biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre Hospitalier Le Mans (CH Le Mans), Service de Soins Intensifs CHU Rouen, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Soins Intensifs CHRU Nancy, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Réanimation Médicale CHRU Nancy, Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes 2016-2019 (UGA 2016-2019 ), Clinique de réanimation médicale, Université Joseph Fourier - Grenoble 1 (UJF)-Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Hôpital Michallon, Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UniCA), Service de Réanimation Médicale Strasbourg, Les Hôpitaux Universitaires de Strasbourg (HUS), Service de Soins Intensifs CHU Caen, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA) |
| المصدر: | ISSN: 2110-5820 ; Annals of Intensive Care ; https://hal.science/hal-02529368Test ; Annals of Intensive Care, 2017, 7 (1), ⟨10.1186/s13613-017-0333-y⟩. |
| بيانات النشر: | HAL CCSD SpringerOpen |
| سنة النشر: | 2017 |
| المجموعة: | Université François-Rabelais de Tours: HAL |
| مصطلحات موضوعية: | Tetanus, Intensive care unit, Outcome, Mechanical ventilation, Elderly patient, Prognosis, Ventilators, Mechanical, Aged, Comorbidity, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract |
| الوصف: | International audience ; Background: An extended course of tetanus (up to 6 weeks) requiring ICU admission and protracted mechanical ventilation (MV) may have a significant impact on short-and long-term survival. The subject is noteworthy and deserves to be discussed. Methods: Twenty-two ICUs in France performed tetanus screenings on patients admitted between January 2000 and December 2014. Retrospective data were collected from hospital databases and through the registers of the town hall of the patients. Results: Seventy patients were included in 15 different ICUs. Sixty-three patients suffered from severe or very severe tetanus according to the Ablett classification. The median age was 80 years [interquartile range 73-84], and 86% of patients were women. Ninety per cent of patients (n = 63) required MV for a median of 36 days [26-46], and 66% required administration of a neuromuscular-blocking agent for 23 days [14-29]. A nosocomial infection occurred in 43 patients (61%). ICU and 1-year mortality rates were 14% (n = 10) and 16% (n = 11), respectively. Forty-five per cent of deaths occurred during the first week. Advanced age, a higher SAPS II, any infection, and the use of vasopressors were significantly associated with a lower number of days alive without ventilator support by day 90. Age was the only factor that significantly differed between deceased and survivors at 1 year (83 [81-85] vs. 79 [73-84] years, respectively; p = 0.03). Sixty-one per cent of survivors suffered no impairment to their functional status. Conclusion: In a high-income country, tetanus mainly occurs in healthy elderly women. Despite prolonged MV and extended ICU length of stay, we observed a low 1-year mortality rate and good long-term functional status. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-02529368; https://hal.science/hal-02529368Test; https://hal.science/hal-02529368/documentTest; https://hal.science/hal-02529368/file/2017_11_09_Tetanos_Mahieu_et_al-2017-Annals_of_Intensive_Care.pdfTest |
| DOI: | 10.1186/s13613-017-0333-y |
| الإتاحة: | https://doi.org/10.1186/s13613-017-0333-yTest https://hal.science/hal-02529368Test https://hal.science/hal-02529368/documentTest https://hal.science/hal-02529368/file/2017_11_09_Tetanos_Mahieu_et_al-2017-Annals_of_Intensive_Care.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.3A47685F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13613-017-0333-y |
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