دورية أكاديمية
Significant Decrease in Hippocampus and Amygdala Mean Diffusivity in Treatment-Resistant Depression Patients Who Respond to Electroconvulsive Therapy
| العنوان: | Significant Decrease in Hippocampus and Amygdala Mean Diffusivity in Treatment-Resistant Depression Patients Who Respond to Electroconvulsive Therapy |
|---|---|
| المؤلفون: | Yrondi, Antoine, Nemmi, Federico, Billoux, Sophie, Giron, Aurélie, Sporer, Marie, Taib, Simon, Salles, Juliette, Pierre, Damien, Thalamas, Claire, Schmitt, Laurent, Péran, Patrice, Arbus, Christophe |
| المساهمون: | Toulouse NeuroImaging Center (ToNIC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre d'investigation clinique de Toulouse (CIC 1436), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse) |
| المصدر: | ISSN: 1664-0640 ; Frontiers in Psychiatry ; https://ut3-toulouseinp.hal.science/hal-03648835Test ; Frontiers in Psychiatry, 2019, 10, pp.694. ⟨10.3389/fpsyt.2019.00694⟩. |
| بيانات النشر: | HAL CCSD Frontiers |
| سنة النشر: | 2019 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | DTI, MRI, depressive disorder, electroconvulsive therapy, mean diffusivity, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
| الوصف: | International audience ; Introduction: The hippocampus plays a key role in depressive disorder, and the amygdala is involved in depressive disorder through the key role that it plays in emotional regulation. Electroconvulsive therapy (ECT) may alter the microstructure of these two regions. Since mean diffusivity (MD), is known to be an indirect marker of microstructural integrity and can be derived from diffusion tensor imaging (DTI) scans, we aim to test the hypothesis that treatment-resistant depression (TRD) patients undergoing bilateral (BL) ECT exhibit a decrease of MD in their hippocampus and amygdala. Methods: Patients, between 50 and 70 years of age, diagnosed with TRD were recruited from the University Hospital of Toulouse and assessed clinically (Hamilton Depression Rating Scale, HAM-D) and by DTI scans at three time points: baseline, V2 (during treatment), and V3 within 1 week of completing ECT. Results: We included 15 patients, who were all responders. The left and right hippocampi and the left amygdala showed a significant decrease in MD at V3, compared to baseline [respectively: β = -2.78, t = -1.97, p = 0.04; β = -2.56, t = -2, p = 0.04; β = -2.5, t = -2.3, p = 0.04, false discovery rate (FDR) corrected]. MD did not decrease in the right amygdala. Only the left amygdala was significantly associated with a reduction in HAM-D (ρ = 0.55, p = 0.049, FDR corrected). Conclusion: MD is an indirect microstructural integrity marker, which decreases in the hippocampus and the left amygdala, during BL ECT in TRD populations. This could be interpreted as a normalization of microstructural integrity in these structures. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31607967; hal-03648835; https://ut3-toulouseinp.hal.science/hal-03648835Test; https://ut3-toulouseinp.hal.science/hal-03648835/documentTest; https://ut3-toulouseinp.hal.science/hal-03648835/file/Yrondi_2019.pdfTest; PUBMED: 31607967; PUBMEDCENTRAL: PMC6761799 |
| DOI: | 10.3389/fpsyt.2019.00694 |
| الإتاحة: | https://doi.org/10.3389/fpsyt.2019.00694Test https://ut3-toulouseinp.hal.science/hal-03648835Test https://ut3-toulouseinp.hal.science/hal-03648835/documentTest https://ut3-toulouseinp.hal.science/hal-03648835/file/Yrondi_2019.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.31F1FFED |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fpsyt.2019.00694 |
|---|