المؤلفون: Emilia Luca, Rossella Lucà, Riccardo Masetti, Silvia Soddu, S. Xiong, G. Lozano, Alfredo Pontecorvi, Luisa Pieroni, Valentina Monteleone, Francesca Mancini, Fabiola Moretti, Andrea Urbani, Laura Fici

المصدر: Oncogene (Basingstoke, Online) 35 (2016): 228–240. doi:10.1038/onc.2015.76
info:cnr-pdr/source/autori:Mancini F, Pieroni L, Monteleone V, Lucà R, Fici L, Luca L, Urbani A, Xiong S, Soddu S, Masetti R, Lozano G, Pontecorvi A, Moretti F./titolo:MDM4%2FHIPK2%2Fp53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response/doi:10.1038%2Fonc.2015.76/rivista:Oncogene (Basingstoke, Online)/anno:2016/pagina_da:228/pagina_a:240/intervallo_pagine:228–240/volume:35
Oncogene

مصطلحات موضوعية: 0301 basic medicine, p53, Cancer Research, Cytoplasm, MDMX, DNA damage, Ubiquitin-Protein Ligases, Molecular Sequence Data, Cell Cycle Proteins, Mice, Transgenic, HIPK2, Protein Serine-Threonine Kinases, 03 medical and health sciences, MDM4, CELL-CYCLE ARREST, Downregulation and upregulation, Proto-Oncogene Proteins, Genetics, Serine, Animals, Humans, Nuclear protein, Molecular Biology, Psychological repression, Settore BIO/10 - BIOCHIMICA, biology, Base Sequence, INTERACTING PROTEIN KINASE-2, Kinase, apoptosis, Nuclear Proteins, Epithelial Cells, Settore MED/13 - ENDOCRINOLOGIA, Fibroblasts, HCT116 Cells, Molecular biology, Mice, Inbred C57BL, 030104 developmental biology, Ser46, biology.protein, Mdm2, Phosphorylation, Original Article, Female, Tumor Suppressor Protein p53, Carrier Proteins, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa886410acf884c1204be867c8841783Test
http://hdl.handle.net/10807/94151Test

المؤلفون: Rossella Lucà, Alfredo Pontecorvi, Fabiola Moretti, Germana Ciolli, Marsha Pellegrino, Emanuela Teveroni

مصطلحات موضوعية: 0301 basic medicine, MDMX, Peptidomimetic, Antineoplastic Agents, Cell Cycle Proteins, Computational biology, Pharmacology, Biology, P53 mdm2, anticancer peptide, Patents as Topic, 03 medical and health sciences, MDM4, therapy-resistance, 0302 clinical medicine, MDM2, Neoplasms, Proto-Oncogene Proteins, Drug Discovery, Animals, Humans, p53 reactivation therapy, Treatment resistance, Drug Discovery3003 Pharmaceutical Science, dual-inhibitor, Nuclear Proteins, P53 Tumor Suppressor, Proto-Oncogene Proteins c-mdm2, Settore MED/13 - ENDOCRINOLOGIA, General Medicine, Small molecule, 030104 developmental biology, Reduced toxicity, 030220 oncology & carcinogenesis, Drug Design, Peptidomimetics, Tumor Suppressor Protein p53, Peptides, Function (biology)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7d0f066f84488c188276bc31097a7eTest
http://hdl.handle.net/10807/91872Test

المؤلفون: Alfredo Pontecorvi, Francesco Trimarchi, Marianna Buttarelli, Francesca Mancini, Fabiola Moretti, Giusy Di Conza

المصدر: Cell cycle (Georget. Tex.) 11 (2012): 749–760.
info:cnr-pdr/source/autori:Giusy Di Conza 1,2; Francesca Mancini 1,3; Marianna Buttarelli 1; Alfredo Pontecorvi 3; Francesco Trimarchi 2; Fabiola Moretti 1/titolo:MDM4 enhances p53 stability by promoting an active conformation of the protein upon DNA damage/doi:/rivista:Cell cycle (Georget. Tex.)/anno:2012/pagina_da:749/pagina_a:760/intervallo_pagine:749–760/volume:11

مصطلحات موضوعية: Conformational change, MDMX, mdm4, DNA damage, Ubiquitin-Protein Ligases, Regulator, Cell Line, Mice, Proto-Oncogene Proteins, Genetic model, Animals, Humans, Immunoprecipitation, Molecular Biology, Cells, Cultured, biology, Protein Stability, Reverse Transcriptase Polymerase Chain Reaction, Proto-Oncogene Proteins c-mdm2, Settore MED/13 - ENDOCRINOLOGIA, Cell Biology, Ubiquitin ligase, Cell biology, Proteasome, Biochemistry, biology.protein, Mdm2, Tumor Suppressor Protein p53, DNA Damage, Protein Binding, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0398ef48e1fcac24b3ce80b2446a04b1Test
http://hdl.handle.net/10807/12478Test

المؤلفون: Fabiola Moretti

المصدر: Molecular & Cellular Oncology 3 (2016): e1066923. doi:10.1080/23723556.2015.1066923
info:cnr-pdr/source/autori:Fabiola Moretti/titolo:Novel insights about the MDM2%2FMDM4 heterodimer/doi:10.1080%2F23723556.2015.1066923/rivista:Molecular & Cellular Oncology/anno:2016/pagina_da:e1066923/pagina_a:/intervallo_pagine:e1066923/volume:3

مصطلحات موضوعية: p53, 0301 basic medicine, Cancer Research, MDMX, DNA damage, Apoptosis, Biology, Molecular biology, Cell biology, MDM4, 03 medical and health sciences, DDB1, 030104 developmental biology, MDM2, heterodimer, Transcriptional repression, biology.protein, Molecular Medicine, Mdm2, Phosphorylation, Protein kinase A, Author's View

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647d746d9b18a084a4621ec651aaba11Test
https://doi.org/10.1080/23723556.2015.1066923Test

المؤلفون: Francesca Mancini, Giusy Di Conza, Marsha Pellegrino, Cinzia Rinaldo, Andrea Prodosmo, Simona Giglio, Igea D'Agnano, Fulvio Florenzano, Lara Felicioni, Fiamma Buttitta, Antonio Marchetti, Ada Sacchi, Alfredo Pontecorvi, Silvia Soddu, Fabiola Moretti

المساهمون: Mancini, Francesca, Di Conza, Giusy, Pellegrino, Marsha, Rinaldo, Cinzia, Prodosmo, Andrea, Giglio, Simona, D'Agnano, Igea, Florenzano, Fulvio, Felicioni, Lara, Buttitta, Fiamma, Marchetti, Antonio, Sacchi, Ada, Pontecorvi, Alfredo, Soddu, Silvia, Moretti, Fabiola

مصطلحات موضوعية: mdm4, mdmx, p53, bcl2, p53ser46(P), mitochondrial apoptosis

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/19521340; info:eu-repo/semantics/altIdentifier/wos/WOS:000267806700011; volume:28; issue:13; firstpage:1926; lastpage:1939; numberofpages:14; journal:EMBO JOURNAL; http://hdl.handle.net/11573/1122314Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-67650501132

الإتاحة: https://doi.org/10.1038/emboj.2009.154Test
http://hdl.handle.net/11573/1122314Test

المؤلفون: Nicola Giacchè, Antonio Macchiarulo, Efisio Puxeddu, Francesca Mancini, Fabiola Moretti, Roberto Pellicciari

المصدر: Expert opinion on therapeutic patents. 21(3)

مصطلحات موضوعية: p53, New horizons, MDMX, Cancer therapy, Mouse Double Minute 2, Computational biology, Biology, Bioinformatics, Patents as Topic, Drug Discovery, ubiquitylation, small molecules, Animals, Humans, neoplasms, Pharmacology, Ubiquitination, Proto-Oncogene Proteins c-mdm2, General Medicine, Small molecule, Ubiquitin ligase, biology.protein, Mdm2, Tumor Suppressor Protein p53, Site of action

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f203fdcf8bce0a557f530f07a91f0465Test
https://pubmed.ncbi.nlm.nih.gov/21342053Test

المؤلفون: Fabiola Moretti, Francesca Mancini

المصدر: Cell cycle (Georget. Tex.) 8 (2009): 3854–3859. doi:10.4161/cc.8.23.10089
info:cnr-pdr/source/autori:Mancini F., Moretti F./titolo:Mitochondrial MDM4 (MDMX): an unpredicted role in the p53-mediated intrinsic apoptotic pathway/doi:10.4161%2Fcc.8.23.10089/rivista:Cell cycle (Georget. Tex.)/anno:2009/pagina_da:3854/pagina_a:3859/intervallo_pagine:3854–3859/volume:8

مصطلحات موضوعية: p53, BCL2, MDMX, DNA damage, Regulator, Apoptosis, Cell Cycle Proteins, Biology, Mitochondrion, mitochondrial apoptosis, Mitochondrial Proteins, MDM4, MDM2, Proto-Oncogene Proteins, Humans, Molecular Biology, Cell growth, Cytochrome c, Nuclear Proteins, Proto-Oncogene Proteins c-mdm2, Cell Biology, Mitochondria, Cell biology, Proto-Oncogene Proteins c-bcl-2, Cancer research, biology.protein, Mdm2, Tumor Suppressor Protein p53, DNA Damage, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9112d8de56ac0511b1a4b3fb03debcTest
http://www.cnr.it/prodotto/i/4927Test

المؤلفون: Simona Giglio, Simona Nanni, Marco D'Angelo, Francesca Mancini, Fabiola Moretti, Gennaro Citro, Francesca Gentiletti, Alfredo Pontecorvi, Carmen D'Angelo, Ada Sacchi, Antonella Farsetti

المصدر: 279/9 (2004): 8169–8180.
info:cnr-pdr/source/autori:Mancini F., Gentiletti F., D'Angelo M., Giglio S., Nanni S., D'Angelo C., Farsetti A., Citro G., Sacchi A., Pontecorvi A., Moretti F./titolo:MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis./doi:/rivista:/anno:2004/pagina_da:8169/pagina_a:8180/intervallo_pagine:8169–8180/volume:279%2F9
The Journal of biological chemistry
279 (2004): 8169–8180. doi:10.1074/jbc.M311793200
info:cnr-pdr/source/autori:Mancini F; Gentiletti F; D'Angelo M; Giglio S; Nanni S; D'Angelo C; Farsetti A; Citro G; Sacchi A; Pontecorvi A; Moretti F/titolo:MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis/doi:10.1074%2Fjbc.M311793200/rivista:The Journal of biological chemistry (Print)/anno:2004/pagina_da:8169/pagina_a:8180/intervallo_pagine:8169–8180/volume:279

مصطلحات موضوعية: Programmed cell death, MDMX, Blotting, Western, Regulator, Gene Expression, Apoptosis, Transfection, Polymerase Chain Reaction, Biochemistry, Culture Media, Serum-Free, Proto-Oncogene Proteins p21(ras), Mice, Structure-Activity Relationship, Bcl-2-associated X protein, Drug Stability, Proto-Oncogene Proteins, In Situ Nick-End Labeling, Animals, Humans, Nuclear protein, Promoter Regions, Genetic, Molecular Biology, Immunosorbent Techniques, bcl-2-Associated X Protein, biology, Nuclear Proteins, Proto-Oncogene Proteins c-mdm2, DNA, mdm4, mdmx, p53, cellular stress induced, Cell Biology, Cell biology, Proto-Oncogene Proteins c-bcl-2, Doxorubicin, Mutagenesis, NIH 3T3 Cells, biology.protein, Mdm2, Tumor Suppressor Protein p53, Cell Division, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75e5c36d0e7b1f5bcc2dc6d2d2903faTest
http://www.cnr.it/prodotto/i/4455Test

المؤلفون: Francesca Gentiletti, Aart G. Jochemsen, Ada Sacchi, Alfredo Pontecorvi, Fabiola Moretti, Marco D'Angelo, Francesca Mancini

المصدر: Oncogene (Basingstoke) 21 (2002): 867–877. doi:10.1038/sj.onc.1205137
info:cnr-pdr/source/autori:Gentiletti F., Mancini F., Pontecorvi A., Sacchi A., Jochemsen A.G., Moretti F./titolo:MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts./doi:10.1038%2Fsj.onc.1205137/rivista:Oncogene (Basingstoke)/anno:2002/pagina_da:867/pagina_a:877/intervallo_pagine:867–877/volume:21

مصطلحات موضوعية: p53, Cancer Research, MDMX, Mutant, Mice, Transactivation, Protein Isoforms, Enzyme Inhibitors, Caspase, medicine.diagnostic_test, biology, Cell Cycle, Nuclear Proteins, Proto-Oncogene Proteins c-mdm2, 3T3 Cells, Cell biology, Cysteine Endopeptidases, Biochemistry, Ethylmaleimide, Caspases, Doxycycline, Mdm2, Intracellular, Half-Life, Transcriptional Activation, Proteasome Endopeptidase Complex, Recombinant Fusion Proteins, Proteolysis, cancro, DNA-DAMAGE, TUMOR-SUPPRESSOR, P53 PROTEIN, ONCOPROTEIN MDM2, APOPTOSIS, Cysteine Proteinase Inhibitors, Transfection, Cleavage (embryo), Feedback, Structure-Activity Relationship, Multienzyme Complexes, Proto-Oncogene Proteins, Consensus Sequence, Genetics, medicine, Animals, Humans, Amino Acid Sequence, Molecular Biology, Ubiquitin, Settore MED/13 - ENDOCRINOLOGIA, Genes, p53, Peptide Fragments, Amino Acid Substitution, Doxorubicin, Mutagenesis, Site-Directed, biology.protein, Tumor Suppressor Protein p53, Protein Processing, Post-Translational

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf56af1dfa023d4fe0da76ab5f54552Test
http://hdl.handle.net/10807/12556Test

المؤلفون: Nicola Giacchè, Roberto Pellicciari, Andrea Carotti, Antonio Macchiarulo, Fabiola Moretti

المصدر: MedChemComm. 2:455

مصطلحات موضوعية: Pharmacology, MDMX, biology, Organic Chemistry, Pharmaceutical Science, Physical interaction, Computational biology, Bioinformatics, Biochemistry, Hedgehog signaling pathway, Review article, Drug Discovery, biology.protein, Molecular Medicine, Mdm2, Cancer

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715b9c223d0d71a2bccd3d4d711c55c8Test
https://doi.org/10.1039/c0md00238kTest