التفاصيل البيبلوغرافية
| العنوان: |
MCP-1 in Alzheimer’s disease patients: A-2518G polymorphism and serum levels |
| المؤلفون: |
Fenoglio, Chiara1, Galimberti, Daniela1 daniela.galimberti@unimi.it, Lovati, Carlo2, Guidi, Ilaria1, Gatti, Alberto1, Fogliarino, Sergio3, Tiriticco, Marco1, Mariani, Claudio2, Forloni, Gianluigi3, Pettenati, Carla4, Baron, Pierluigi1, Conti, Giancarlo1, Bresolin, Nereo1, Scarpini, Elio1 |
| المصدر: |
Neurobiology of Aging. Oct2004, Vol. 25 Issue 9, p1169-1173. 5p. |
| مصطلحات موضوعية: |
*ALZHEIMER'S disease, *GENETIC polymorphisms, *HEREDITY, *HUNTINGTON disease |
| مستخلص: |
MCP-1 levels are increased in CSF of patients with Alzheimer’s disease (AD) compared with controls, suggesting a role in the development of dementia. Recently, a biallelic A/G polymorphism in the MCP-1 promoter at position -2518 has been found, influencing the level of MCP-1 expression in response to an inflammatory stimulus. The distribution of the A-2518G SNP was determined in 269 AD patients and in 203 healthy age matched controls, showing no differences between the two groups. On the contrary, a significant increase of MCP-1 serum levels in AD patients carrying at least one G mutated allele was observed. Moreover, the highest peaks of MCP-1 serum levels were present in patients carrying two G alleles. Stratifying by ApoE genotype, gender or age at onset, no differences in both allele frequency and MCP-1 serum concentration were observed.The A-2518G polymorphism in MCP-1 gene does not seem to be a risk factor for the development of AD, but its presence correlates with higher levels of serum MCP-1, which can contribute to increase the inflammatory process occurring in AD. [Copyright &y& Elsevier] |
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