التفاصيل البيبلوغرافية
| العنوان: |
Local and Systemic Antibody Responses in Beef Calves Vaccinated with a Modified-Live Virus Bovine Respiratory Syncytial Virus (BRSV) Vaccine at Birth following BRSV Infection. |
| المؤلفون: |
Martínez, David A., Chamorro, Manuel F., Passler, Thomas, Huber, Laura, Walz, Paul H., Thoresen, Merrilee, Raithel, Gage, Silvis, Scott, Stockler, Ricardo, Woolums, Amelia R. |
| المصدر: |
Veterinary Sciences; Jan2023, Vol. 10 Issue 1, p20, 13p |
| مصطلحات موضوعية: |
MATERNALLY acquired immunity, IMMUNOGLOBULINS, RESPIRATORY syncytial virus, ANTIBODY formation, CALVES, VACCINE effectiveness, ANTIBODY titer |
| مستخلص: |
Simple Summary: Bovine respiratory syncytial virus (BRSV) is a common cause of respiratory disease in calves. Vaccination of young calves against BRSV is a common prevention strategy; however, antibodies derived from maternal colostrum interfere with vaccine response and efficacy in young calves. The objective of this study was to determine if vaccination before colostrum absorption results in the effective induction of immune responses and clinical protection in calves. Within 6 h of birth, beef calves were assigned to 2 different treatment groups. Group Vacc (n = 25) was vaccinated with a modified-live virus (MLV) intranasal (IN) BRSV vaccine. Group Control (n = 25) remained unvaccinated. At approximately 3 months of age, calves were experimentally infected with BRSV. Immune responses and viral shedding were evaluated before and after infection. Respiratory signs before and after infection as well as viral shedding were similar between Vacc and Control calves. Local and systemic antibody responses were similar and suggested natural BRSV exposure before experimental infection. Based on the results from this study, early vaccination does not provide advantages for the clinical protection of calves from endemic BRSV farms. Maternal antibodies interfere with BRSV vaccine responses and efficacy in young calves. The objective of this study was to determine if vaccination before the complete absorption of colostral antibodies results in adequate immune priming and clinical protection of beef calves. Within 6 h of life, calves were randomly assigned to 2 different treatment groups. Group Vacc (n = 25) received a single dose of a modified-live virus (MLV) BRSV vaccine intranasally (IN) and group Control (n = 25) received 2 mL of 0.9% saline IN. At approximately 3 months of age, all calves were experimentally challenged with BRSV. Serum and nasal secretion samples were collected before and after challenge for BRSV real-time RT-PCR and antibody testing. Respiratory signs were not observed before challenge. After challenge, respiratory scores were similar between groups. On the challenge day, >40% of calves in each group were febrile. The mean serum and nasal BRSV-specific antibody titers indicated natural BRSV exposure before the experimental challenge in both groups. All calves tested positive for BRSV and had a similar duration of shedding after challenge. Based on these results, vaccination at birth does not offer advantages for immune priming or clinical protection for beef calves in BRSV-endemic cow-calf herds. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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