دورية أكاديمية
Characterising the effect of geometry on a microchamber for producing controlled concentration gradients
| العنوان: | Characterising the effect of geometry on a microchamber for producing controlled concentration gradients |
|---|---|
| المؤلفون: | Glover, Katherine, Strang, Jon, Lubansky, Alex |
| المصدر: | Research outputs 2014 to 2021 |
| بيانات النشر: | Edith Cowan University, Research Online, Perth, Western Australia |
| سنة النشر: | 2014 |
| المجموعة: | Edith Cowan University (ECU, Australia): Research Online |
| مصطلحات موضوعية: | Concentration field, Mass transfer, Microfluidics, Quiescent environment, Geometry, Biofilm development, Concentration fields, Concentration gradients, Concentration profiles, Diffusion chamber, Equilibrium time, Micro-chambers, Quiescent environments, Chemical Engineering |
| الوصف: | A microfluidic diffusion chamber with 3 inlets and a circular central chamber allows a 2D concentration gradient to develop. This diffusion chamber has been characterised numerically for the effect geometry has on equilibrium time, the concentration profile and the flow profile within the central chamber. As the Einstein-Smoluchowski relation predicts, the time to reach steady state is proportional to the square of the radius of the chamber but features within the chamber are qualitatively insensitive to the size of the chamber within the range of 100-1000. μm. Inlet width had a much more significant effect on the qualitative behaviour within the chamber, affecting the symmetry of the concentration profile. It is recommended that inlet widths are less than 80. μm to preserve symmetry. In this paper, the effect of geometry on both transient and steady-state behaviour has been explored, providing a basis and criteria for designing chambers for a wide range of applications, including studying the effect of concentration gradients on cell mobility or a rapid assay for biofilm development in a range of concentrations. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://ro.ecu.edu.au/ecuworkspost2013/87Test; http://dx.doi.org/10.1016/j.ces.2014.06.045Test |
| DOI: | 10.1016/j.ces.2014.06.045 |
| الإتاحة: | https://doi.org/10.1016/j.ces.2014.06.045Test https://ro.ecu.edu.au/ecuworkspost2013/87Test |
| حقوق: | subscription content |
| رقم الانضمام: | edsbas.2D6A2A2C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ces.2014.06.045 |
|---|