المؤلفون: Jared R. Ramsey, Patrick M. M. Shelton, Tyler K. Heiss, Paul Dominic B. Olinares, Lauren E. Vostal, Heather Soileau, Michael Grasso, Sara W. Casebeer, Stephanie Adaniya, Michael Miller, Shan Sun, David J. Huggins, Robert W. Myers, Brian T. Chait, Ekaterina V. Vinogradova, Tarun M. Kapoor

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, utilize energy derived, scout fragments inhibit, high conformational dynamics, enantiomeric probe pairs, diverse cellular processes, combining enzymatic assays, certain cancer cells, chemical proteomic studies, druggable allosteric sites, two human superfamily, develop chemical inhibitors, conformationally dynamic mechanoenzymes, develop covalent inhibitors, chemical probes, covalent inhibitor, allosteric site, six superfamilies, selectively targets, rna substrates, ribosome assembly, remodel dna, mass spectrometry, many viruses, key roles

العلاقة: https://figshare.com/articles/journal_contribution/Using_a_Function-First_Scout_Fragment_-Based_Approach_to_Develop_Allosteric_Covalent_Inhibitors_of_Conformationally_Dynamic_Helicase_Mechanoenzymes/24896834Test

الإتاحة: https://doi.org/10.1021/jacs.3c10581.s001Test
https://figshare.com/articles/journal_contribution/Using_a_Function-First_Scout_Fragment_-Based_Approach_to_Develop_Allosteric_Covalent_Inhibitors_of_Conformationally_Dynamic_Helicase_Mechanoenzymes/24896834Test

المؤلفون: John C Zinder, Paul Dominic B Olinares, Vladimir Svetlov, Martin W Bush, Evgeny Nudler, Brian T Chait, Thomas Walz, Titia de Lange

مصطلحات موضوعية: Microscopy, Electron, Multidisciplinary, Protein Domains, Humans, Mass Spectrometry, Shelterin Complex

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ea6980c8b96984ec008a37f1fc0354Test
https://doi.org/10.1101/2022.01.24.477420Test

المؤلفون: Curtis A. Engelhart, Nadine Ruecker, Joshua B. Wallach, Jeremy M. Rock, Wenzhu Zhang, Brian T. Chait, Shuqi Li, Anisha Zaveri, Sabine Ehrt, Nicholas C. Poulton, Barbara Bosch, Sophie Lavalette, Michael A. DeJesus, Dirk Schnappinger, Carolina Trujillo

المصدر: Cell

مصطلحات موضوعية: Resource, Mycobacterium smegmatis, Antitubercular Agents, Vulnerability, Computational biology, Microbial Sensitivity Tests, Genome, Essential genes, General Biochemistry, Genetics and Molecular Biology, Mass Spectrometry, Mycobacterium tuberculosis, Amino Acyl-tRNA Synthetases, Drug Development, Clustered Regularly Interspaced Short Palindromic Repeats, Gene Silencing, Gene, CRISPR interference, biology, Drug discovery, Bayes Theorem, Gene Expression Regulation, Bacterial, biology.organism_classification, Bacterial Processes, Biological Evolution, Drug development, CRISPR-Cas Systems, Functional genomics, Genome, Bacterial, RNA, Guide, Kinetoplastida

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51a8e0e5c7fda3375250368b902ccaaTest
https://pubmed.ncbi.nlm.nih.gov/34297925Test

المؤلفون: Brian T. Chait, Ryan Mayle, Dan Zhang, Lance D. Langston, Kelly R. Molloy, Mike O'Donnell

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: DNA Replication, CMG helicase, Saccharomyces cerevisiae Proteins, Biochemistry, Mass Spectrometry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Replication Protein A, SMARCAL1, Annealing activity, Humans, Translocase, fork regression, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Minichromosome Maintenance Proteins, biology, DNA Helicases, DNA replication, Helicase, DNA, Biological Sciences, GINS, Cell biology, Chemistry, chemistry, Mcm10, Physical Sciences, biology.protein, MCM10, Replisome, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdbced62c0f5870ebf98f67caeb119dTest
https://doi.org/10.1073/pnas.1819107116Test

المؤلفون: Ruth M. Saecker, C.E. Chiu, Seth A. Darst, James Chen, Eliza Llewellyn, Paul Dominic B. Olinares, Brian T. Chait, Jin Young Kang, Brandon Malone, Elizabeth A. Campbell

المصدر: Structure

مصطلحات موضوعية: Materials science, Coronavirus disease 2019 (COVID-19), Cryo-electron microscopy, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), High resolution, Nanotechnology, Viral Nonstructural Proteins, Mass spectrometry, Mass Spectrometry, Article, 03 medical and health sciences, Structural Biology, Escherichia coli, Sample preparation, Mass analysis, Molecular Biology, 030304 developmental biology, 0303 health sciences, SARS-CoV-2, Escherichia coli Proteins, 030302 biochemistry & molecular biology, Cryoelectron Microscopy, Methyltransferases, Single Molecule Imaging, Sample quality, RNA Helicases, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf3ab2831bb113cc3f0fafaa259f494Test
https://pubmed.ncbi.nlm.nih.gov/33217329Test

المؤلفون: James Chen, Brian T. Chait, C.E. Chiu, Eliza Llewellyn, Jin Young Kang, Elizabeth A. Campbell, Seth A. Darst, Paul Dominic B. Olinares, Brandon Malone, Ruth M. Saecker

المصدر: SSRN Electronic Journal.

مصطلحات موضوعية: Sample quality, Resource center, Coronavirus disease 2019 (COVID-19), Competing interests, Computer science, Cryo-electron microscopy, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Common fund, Nanotechnology, Mass spectrometry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e1cf9b86f8256bc43c80830597143a4cTest
https://doi.org/10.2139/ssrn.3689208Test

المؤلفون: Paul Dominic B. Olinares, Brian T. Chait

المصدر: Methods in Molecular Biology ISBN: 9781493998210

مصطلحات موضوعية: 0301 basic medicine, Protease, Exosome complex, Chemistry, Protein subunit, medicine.medical_treatment, 010401 analytical chemistry, Cleavage (embryo), Mass spectrometry, Orbitrap, 01 natural sciences, Exosome, Yeast, 0104 chemical sciences, law.invention, 03 medical and health sciences, 030104 developmental biology, Biochemistry, law, medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9a9dc655d4fb0158f62f9843e2517218Test
https://doi.org/10.1007/978-1-4939-9822-7_17Test

المؤلفون: Javier Fernandez-Martinez, Paul Dominic B. Olinares, Amelia Dunn, Brian T. Chait, Julio C. Padovan, Michael P. Rout

المصدر: Analytical Chemistry. 88:2799-2807

مصطلحات موضوعية: 0301 basic medicine, Spectrometry, Mass, Electrospray Ionization, 030102 biochemistry & molecular biology, Chemistry, Protein subunit, Proteins, Endogeny, Mass spectrometry, Combinatorial chemistry, Mass spectrometric, Chromatography, Affinity, Article, Analytical Chemistry, 03 medical and health sciences, 030104 developmental biology, Biophysics, Electrophoresis, Polyacrylamide Gel, Macromolecule

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40b6c2dcf66ef7601f6ad0cc87be7dfTest
https://doi.org/10.1021/acs.analchem.5b04477Test

المؤلفون: Martina Kopp, Brian T. Chait, Charles M. Rice, Kelly R. Molloy, Gema Vizcay-Barrena, Marcus Dorner, Marion Lussignol, Maria Teresa Catanese, Roland A. Fleck, Kierstin L. Bell

المصدر: Lussignol, M, Kopp, M, Molloy, K, Vizcay-Barrena, G, Fleck, R A, Dorner, M, Bell, K L, Chait, B T, Rice, C M & Catanese, M T 2016, ' Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis ', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 9, pp. 2484-2489 . https://doi.org/10.1073/pnas.1518934113Test

مصطلحات موضوعية: Proteomics, 0301 basic medicine, Viral nonstructural protein, viruses, Molecular Sequence Data, 030106 microbiology, Hepacivirus, Biology, Virus-host interactions, Mass Spectrometry, Virus, Cell Line, Viral Proteins, 03 medical and health sciences, Viral envelope, Morphogenesis, Enveloped virus, Humans, Amino Acid Sequence, Nucleoporin, chemistry.chemical_classification, NS3, Multidisciplinary, Flaviviridae, Virion, virus diseases, biochemical phenomena, metabolism, and nutrition, Biological Sciences, Virology, digestive system diseases, Nuclear Pore Complex Proteins, NS2-3 protease, 030104 developmental biology, Capsid, chemistry, Glycoprotein, Virion proteomics

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145a29690862c79ea0bb1a155f6e87d9Test
https://doi.org/10.1073/pnas.1518934113Test

المؤلفون: Dmitry G. Alexeev, Sana Badri, Ilya Altukhov, Paolo Mita, Hao Jiang, Brian T. Chait, Emily M. Adney, Martin S. Taylor, Aleksandra Wudzinska, John LaCava, Michael P. Rout, Dmitry S. Ischenko, George Eng, Jef D. Boeke, Kathleen H. Burns, Kelly R. Molloy, David Fenyö

المصدر: eLife, Vol 7 (2018)
eLife

مصطلحات موضوعية: 0301 basic medicine, Retrotransposon, interactome, Interactome, Genome, Chromatography, Affinity, Mass Spectrometry, LINE-1, Biology (General), health care economics and organizations, General Neuroscience, food and beverages, RNA-Directed DNA Polymerase, General Medicine, Virus, 3. Good health, Retrotransposons, Ribonucleoproteins, Genomics and Evolutionary Biology, Medicine, cell cycle, Insight, Research Article, Computational and Systems Biology, Human, Transposable element, endocrine system, Macromolecular Substances, QH301-705.5, Science, Chemical biology, Computational biology, Biology, behavioral disciplines and activities, General Biochemistry, Genetics and Molecular Biology, ribonucleoprotein, 03 medical and health sciences, Biochemistry and Chemical Biology, ORF1p, Humans, biochemistry, affinity proteomics, Gene, General Immunology and Microbiology, retrotransposon, DNA replication, RNA, social sciences, Cell Biology, Endonucleases, Long Interspersed Nucleotide Elements, 030104 developmental biology, ORF2p, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059831d3499fc8f521aa88179f0017eeTest
https://elifesciences.org/articles/30094Test