التفاصيل البيبلوغرافية
العنوان:
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study
المؤلفون:
O'Connell, Rachel L , Rattay, Tim , Dave, Rajiv V , Trickey, Adam , Skillman, Joanna , Barnes, Nicola LP , Gardiner, Matthew , Harnett, Adrian , Potter, Shelley , Holcombe, Chris , Blazeby, Jane , Conroy, Elizabeth , O'Brien, Ciara , Williamson, Paula , Curnier, Alain , Tadros, Amir , Depasquale, Ivan , Masannat, Yazan A , Smyth, Elizabeth , Fuller, Mairi , Bourne, Roger , Heys, Steven , Hamo, Ishrak , Aloraifi, Fatima , Fopp, Laura , Bali, Radhika , Bache, Sarah , Benyon, Sarah L , Irwin, Michael S , Agrawal, Amit , Malata, Charles M , Murphy, Claire , Misky, Adam , Chicken, Dennis Wayne , Abdullah, Nassreen , Hill, Arnold DK , Cullinane, Carolyn , Irwin, Gareth , McIntosh, Stuart A , Refsum, Sigi , Sloan, Samantha , Mallon, Peter , Sirianni, Chiara , Khattak, Ilyas , Nagachandra, Geerthan , Kiruparan, Pasupathy , Debanth, Debasish , Davey, Simon , Curran, Terry-Ann , Svenning, Matilda , Govindarajulu, Sasirekha , Rayter, Zenon , Ainsworth, Rachel , Cawthorn, Simon , Sahu, Ajay , Wilson, Sherif , Prousskaia, Elena , Accurso, Antonello , Rocco, Nicola , Di Micco, Rosa , Limite, Gennaro , Ceccarino, Raffaele , Liccardo, Raffaele , Coco, Guido , Nizamoglu, Metin , Morgan, Mary , Ramakrishnan, Venkat , Catanuto, Giuseppe , Wilkins, Alex , McManus, Penelope , Kneeshaw, Peter , Grover, Kartikae , Mahapatra, Tapan , Wooler, Brendan , Elahi, Bilal , Ihsan, Naila , Bucknor, Alexandra , Reissis, Dimitris , Hunter, Judith , Wood, Simon , Jallali, Navid , Henry, Francis P , Verjee, Liaquat S , Lee, Jason , Khan, Shazia M , Azmy, Iman , Massey, Julia , Hollywood, Ciaran , Oluwajana, Michael , Bathla, Sonia , Seward, Joanna , Harding-MacKean, Claudia , Lane, Risha , Murali, Kothandaraman , Biswas, Bashishta , Trapszo, Pawel , Seetharam, Seema , Kennedy, Katy , Alder, Louise , Graja, Tomasz , Amin, Khalid , Kokan, Jalal , Roshanlall, Chandeena , Gill, Emma , Kulkarni, Dhananjay , Dixon, JM , Young, Oliver , Saleem, Talha , Biddle, M , Kearns, Marie , Weiler-Mithoff, Eva , Chew, Ben , Malyon, Andy , Scott, John , McGill, David , Mackay, Iain , Bains, Salena , Barrows, Sara , Pilgrim, Simon , Shokuhi, Sheila , Lambert, Kelly , Kenny, Frances , Valassiadou, Kalliope , Kaushik, Monika , Krupa, Jaroslaw , Dragoumis, Dimitris , Ain, Quratul , Lampropoulos, Pavlos , Moss, Sarah , Khalil, Haitham , Haq, Anwar , Balasubramanian, Balapathiran , Charalampou-Dis, Petros , Hamed, Hisham , Kothari, Ashutosh , Kovacs, Tibor , Douek, Michael , Mehmood, Iftikhar , Ray, Biswajit , Adelekan, Matthew , Humphreys, Laura , Tayeh, Salim , Choy, Christina , Parvanta, Laila , Michieletto, Silvia , Saibene, Tania , O'Brien, James , Down, Sue , Downey, Sarah , Pereira, Jerome , Sami, AS , Gvaramadze, Anzors , Jibril, Jibril A , Thekkinkattil, Dinesh , Udayasankar, S , Khawaja, Saira , Shariaha, Yousef , Holt, Simon , James, Ruth , Rizki, Hirah , Kirkpatrick, Katharine , Ravichandran, Duraisamy , Shrestha, Deepak , Barua, Ellora , Akolekar, Deepika , Hamad, Ahmed , Kleidi, Eleftheria , Hignett, Susan , Pope, Vanessa , Naseem, Salma , Isherwood, Jennifer , Soulsby, Rachel , Taylor, Amanda , Chin, Kian , Nguyen, Dai , Guest, Francesca , Thorne, Amanda , Kirchhoff, Chris , Murphy, Declan C , Lo, Michelle , Harcourt, Ruth , Pain, Simon J , Hussien, Maged I , Zechmeister, Katalin , Sassoon, EM , Figus, Andrea , Haywood, Richard M , Ali, Rozina , Alexander, Susanna , Geropantas, Konstantinos , Epurescu, Daniel , Lewis, Rebecca , Fafemi, Oladapo , Gahir, Jasdeep , Gandamihardja, Tasha , Kelsall, Jennett , Muhibullah, Nazli , Otieno, Charlene , Mazari, Fayyaz , Dauria, Marta , Whisker, Lisa , Macmillan, Douglas , Gutteridge, Eleanor , Rasheed, Tuabin , Khout, Hazem , Asgeirsson, Kristjan , McCulley, Stephen , Mariniello, Maria Donatella , Roncella, Manuela , Ghilli, Matteo , Colizzi, Livio , Rossetti, Elena , Marzia, Lo Russo , Fustaino, Loredana , Li, Alessandro Quattrini , Harvey, Kate L , Windle, Rebecca , Remoundos, Dionysios Dennis , Roy, Pankaj , MacLean, Gael , Adwani, Asha , Popa, Elena , Goh, Steven , Shetty, Geeta , Clark, Sarah , Bernaudo, Lorenzo , Agrawal, Avi , Mansfield, Lucy , Tebbal, Sally , Patel, Ashraf , Grassi, Veronica , Pujji, Ojas , Hamnett, Kathryn , Basu, Naren , Granger, Emily , Durbar, Michael , Pikoulas, Panagiotis , Garnsey, Clare , Walker, Philip , Vollermere, Angela J , Michalakis, Ioannis , Jones, Robin , Youssef, Mina , Ives, Charlotte , Masood, Mohammad , Dunn, Julie , Olsen, Sisse , Ferguson, Douglas , Tillett, Rachel , Allan, Anna , Woollard, Alex , Canny, Rebecca , Woollard, Alexander , Mosahebi, Afshin , Hamilton, Stephen , Ghali, Shadi , Marsh, Daniel , Chana, Jagdeep , Sojitra, Nilesh , Younis, Ibby , Rainsbury, Dick , Chand, Natalie , Kalles, Vasileios , Stebbing, Anne , Harris, Kevin , Laws, Siobhan , Tansley, Anne , Mitchell, Geraldine , de Sousa, Emma , Henderson, Julia , Chandrashekar, Mysore , Pereira, Bernadette , Constantinou, Chloe , Elfadl, Dalia , Irakleidis, Foivos , Hernan, Izaro , Byrne, Miriam , To, Natalie , O'Connell, Rachel , Rusby, Jennifer , Barry, Peter , Krupa, Katerine , Allum, William , MacNeill, Fiona , Roche, Nicola , Gui, Gerald , Ramsey, Kelvin , Harris, Paul , James, Stuart , Power, Kieran , Sutton, Richard , McIntosh, Jamie , Laurence, Nicola , MacLennan, Louise , Milligan, Robert , Cain, Henry , Critchley, Adam , O'Donoghue, Joe , Kalra, Loraine , Collis, Nick , Weston-Petrides, Gina , Fiddes, Roanne , Brown, Victoria , Aertssen, Anna , Slade-Sharman, Diana , Khan, Mansoor , McGuiness, Caroline , Amorosi, Vittoria , Fabio, Santanelli di Pompeo , Exarchos, Georgios , Jiwa, Natasha , Hu, Jennifer , Ledwidge, Serena , Johnson, Laura , Peel, Anthony , Dhooma, Naseem , Farrell, Eric , Devane, Liam , Tevlin, Ruth , McDermott, Enda , Prichard, Ruth , Evoy, Denis , Rothwell, Jane , Geraghty, James , Morrison, Colin , Lawlor, Catriona , Langlands, Fiona , Taylor, Lauren , Turton, Philip , Achuthan, Raj , Horgan, Kieran , Mckenzie, Shireen , Hogan, Brian , Lansdown, Mark , Navin, Channegowda , Sherwin, Liz , Mortimer, Caroline , Garg, Neeraj , Adam, Rahma , Arif, Tahera , Kryjak, Zbigniew , Ali, Deedar , Sowdi, Ravi , Fage, Elena , Mylvaganam, Senthurun , Matey, Pilar , Vidya, Raghavan , Sircar, Tapan , Asaad, Oubida , Bhaskar, Pud , Dordea, Matei , Chrysafi, Ada , McCartan, Damian , Dave, Rajiv , Foster, Rachel , Wilson, Rebecca , Okwemba, Sylvia , Majeed, Yousef , Mathen, Vinod , Murphy, John , Barnes, Nicola , Gandhi, Ashu , Harvey, James , Kirwan, Cliona C , Johnson, Richard , Patel, Krupali , Ribas, Maria Dalmau , Vigneswaran, Natali , Challoner, Tom , Park, Alan , Rizkalla, Maged , Tomlins, Abigail , McEvoy, Kat , Jafferbhoy, Sadaf , Soumian, Soni , Narayanan, Sankaran , Kirby, Robert , Bajrusevic, Sladana , Maalo, Joseph , Charalambous, Michalis , Lai, Lee Min , Chong, Kelvin , Thomson, Simon , Monib, Sherif , Chagla, Leena , Audisio, Riccardo , Taghizadeh, Rieka , Iqbal, Azhar , James, Karen , Callaghan, Maria , Poonawala, Shabbir , Lund, Jonathan , Vinayagam, Raman , Thrush, Steven , Thomas, Rachel Bright , Mullan, Michelle , Taylor, Jevan , Yoshimura, Ryo , Mathew, Tom , Jones, Ben Mancey , Munot, Kailas , Nasr, Rana , Piper, Jenny , El-Sharief, Deena , Mustafa, Mohammed , Dumitru, Dorin , Christopoulos, Petros , O'Leary, Peter , Athanasiou, Irene , Johns, Neil , Mehta, Disha , Bibi, Saira , Syed, Farah , Koris, Jacob , Healy, Samuel , Shanks, Lindsay , Oliver, James , Bucata, Claudiu , Clarke, Natalie , Bignell, Kym , Akerlund, Malin , Brock, Lisa , Hallam, Kelly , Howes, Rachel , Armstrong, Alexander , Sethu, Claire , Zeidan, Bashar , Sjokvist, Olivia , Tasoulis, Marios , Sundaramoorthy, Souganthy , Harris, Chad , Wintrip, Dorothy , Lymperopoulos, N , Jain, Yogesh , Balata, Safa Ahmed , Grp, iBRA-2 Steering , Collab, Breast Reconstruction Res
المصدر:
BRITISH JOURNAL OF CANCERhttps://doi.org/10.1038/s41416-019-0438-1Test https://doi.org/10.1038/s41416-019-0438-1Test
سنة النشر:
2019
مصطلحات موضوعية:
Adult , Cancer Research , medicine.medical_specialty , Time Factors , medicine.medical_treatment , Mammaplasty , trainee collaboratives , Breast Neoplasms , Article , Cohort Studies , 03 medical and health sciences , Young Adult , 0302 clinical medicine , Breast cancer , breast cancer , Adjuvant therapy , cohort study , Medicine , Humans , Prospective Studies , Prospective cohort study , Mastectomy , Aged , Cancer , Aged, 80 and over , Manchester Cancer Research Centre , business.industry , ResearchInstitutes_Networks_Beacons/mcrc , adjuvant therapy , immediate breast reconstruction , Middle Aged , medicine.disease , Surgery , Radiation therapy , Oncology , Centre for Surgical Research , Chemotherapy, Adjuvant , Outcomes research , 030220 oncology & carcinogenesis , Surgical oncology , Female , Breast reconstruction , business , Complication , Cohort study
الوصف:
Background: Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy.Methods: Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored.Results: A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays.Conclusions: IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients.
وصف الملف:
application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/pdf
اللغة:
English
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51675ae41f69e5c95a6e781231cdfcfcTest http://livrepository.liverpool.ac.uk/3041762/1/iBRA2_revised_FINAL_BJC_FORMATTED.docxTest
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....51675ae41f69e5c95a6e781231cdfcfc
قاعدة البيانات:
OpenAIRE
