Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size
| العنوان: | Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size |
|---|---|
| المؤلفون: | Annika Warnatsch, Theodora Dorita Tsourouktsoglou, Maximiliano G. Gutierrez, Susanna Reincke, Nora Branzk, Susanne Herbst, Qian Wang, Venizelos Papayannopoulos |
| المصدر: | Warnatsch, A, Tsourouktsoglou, T D, Branzk, N, Wang, Q, Reincke, S, Herbst, S, Gutierrez, M & Papayannopoulos, V 2017, ' Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size ', Immunity, vol. 46, no. 3, pp. 421-432 . https://doi.org/10.1016/j.immuni.2017.02.013Test Immunity |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Phagocyte, cellular stoichiometry, Neutrophils, interleukin-1β, Immunology, Inflammation, Biology, Article, Microbiology, 03 medical and health sciences, Mice, Immune system, Candida albicans, medicine, Immunology and Allergy, Animals, Humans, cluster, Pathogen, chemistry.chemical_classification, reactive oxygen species, Reactive oxygen species, Bacteria, fungal infection, Interleukin, neutrophil, Bacterial Infections, biology.organism_classification, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, chemistry, Mycoses, Neutrophil Infiltration, inflammation, swarm, Female, microbe size, Mitosporic Fungi, medicine.symptom, Signal transduction, Reactive Oxygen Species |
| الوصف: | Summary How the number of immune cells recruited to sites of infection is determined and adjusted to differences in the cellular stoichiometry between host and pathogen is unknown. Here, we have uncovered a role for reactive oxygen species (ROS) as sensors of microbe size. By sensing the differential localization of ROS generated in response to microbes of different size, neutrophils tuned their interleukin (IL)-1β expression via the selective oxidation of NF-κB, in order to implement distinct inflammatory programs. Small microbes triggered ROS intracellularly, suppressing IL-1β expression to limit neutrophil recruitment as each phagocyte eliminated numerous pathogens. In contrast, large microbes triggered ROS extracellularly, amplifying IL-1β expression to recruit numerous neutrophils forming cooperative clusters. Defects in ROS-mediated microbe size sensing resulted in large neutrophil infiltrates and clusters in response to small microbes that contribute to inflammatory disease. These findings highlight the impact of ROS localization on signal transduction. Graphical Abstract Highlights • The clearance of microbes of different size involves distinct inflammatory programs • ROS adjusts neutrophil recruitment to the stoichiometry of host-pathogen interactions • ROS localization acts as a sensor of microbe size to tune IL-1-β-driven inflammation • IL-1β amplifies neutrophil recruitment and clustering to clear large microbes Inflammation recruits neutrophils to fight invading pathogens of different size. Warnatsch et al. show that reactive oxygen species localization tunes inflammation to compensate for differences in the number of neutrophils required to clear microbes of different size. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa750b25608a6ca29d726d58b3cd5c3fTest https://kclpure.kcl.ac.uk/ws/files/141617260/Reactive_Oxygen_Species_Localization_Programs_Inflammation_WARNATSCH_Publishedonline14March2017_GOLD_VoR_CC_BY_.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fa750b25608a6ca29d726d58b3cd5c3f |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |