المؤلفون: Booth, Stephen W, Eyre, Toby A, Whittaker, John, Campo, Leticia, Wang, Lai Mun, Soilleux, Elizabeth, Royston, Daniel, Rees, Gabrielle, Kesavan, Murali, Hildyard, Catherine, Kazmi, Farasat, La Thangue, Nick, Kerr, David, Middleton, Mark R, Collins, Graham P

مصطلحات موضوعية: Biomarker, HR23B, Histone deacetylase (HDAC), Lymphoma, Adult, Aged, Biomarkers, Tumor, DNA Repair Enzymes, DNA-Binding Proteins, Female, Gene Expression, Histone Deacetylase Inhibitors, Humans, Immunohistochemistry, Male, Middle Aged, Neoplasm Staging, Neoplasms, Treatment Outcome

وصف الملف: Electronic; application/pdf

العلاقة: https://www.repository.cam.ac.uk/handle/1810/328502Test

الإتاحة: https://doi.org/10.17863/CAM.75950Test
https://www.repository.cam.ac.uk/handle/1810/328502Test

المؤلفون: Dalle, Stéphane, Mortier, Laurent, Corrie, Pippa, Lotem, Michal, Board, Ruth, Arance, Ana María, Meiss, Frank, Terheyden, Patrick, Gutzmer, Ralf, Buysse, Brian, Oh, Kelly, Brokaw, Jane, Le, T Kim, Mathias, Susan D, Scotto, Julie, Lord-Bessen, Jennifer, Moshyk, Andriy, Kotapati, Srividya, Middleton, Mark R

مصطلحات موضوعية: Advanced melanoma, Ipilimumab, Overall survival, Quality of life, Real-world, Subsequent therapy, Adult, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Chemoradiotherapy, Female, Follow-Up Studies, Humans, Immune Checkpoint Inhibitors, Male, Melanoma, Middle Aged, Prospective Studies, Radiosurgery, Skin Neoplasms, Survival Analysis, Treatment Outcome, Young Adult

وصف الملف: text/xml; application/pdf; application/zip

العلاقة: https://www.repository.cam.ac.uk/handle/1810/323189Test

الإتاحة: https://doi.org/10.17863/CAM.70643Test
https://www.repository.cam.ac.uk/handle/1810/323189Test

المؤلفون: Gao, Shan, Bajrami, Ilirjana, Verrill, Clare, Kigozi, Asha, Ouaret, Djamila, Aleksic, Tamara, Asher, Ruth, Han, Cheng, Allen, Paul, Bailey, Deborah, Feller, Stephan, Kashima, Takeshi, Athanasou, Nicholas, Blay, Jean-Yves, Schmitz, Sandra, Machiels, Jean-Pascal, Upile, Nav, Jones, Terry M, Thalmann, George, Ashraf, Shazad Q, Wilding, Jennifer L, Bodmer, Walter F, Middleton, Mark R, Ashworth, Alan, Lord, Christopher J, Macaulay, Valentine M

المساهمون: UCL - (SLuc) Centre du cancer, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Unité d'oncologie médicale, UCL - (SLuc) Service d'oto-rhino-laryngologie

المصدر: Cancer research, Vol. 74, no.20, p. 5866-77 (2014)

مصطلحات موضوعية: Adaptor Proteins, Signal Transducing, Animals, Antineoplastic Agents, Carcinoma, Squamous Cell, Cell Line, Tumor, Dishevelled Proteins, Drug Resistance, Neoplasm, Gene Expression, Head and Neck Neoplasms, Humans, Inhibitory Concentration 50, Insulin-Like Growth Factor I, Isoxazoles, MAP Kinase Signaling System, Male, Mice, Phosphoproteins, Pyrimidines, Receptor, IGF Type 1, Wnt Proteins, Xenograft Model Antitumor Assays, ras Proteins

العلاقة: boreal:245573; http://hdl.handle.net/2078.1/245573Test; info:pmid/25168481; urn:EISSN:1538-7445

الإتاحة: https://doi.org/10.1158/0008-5472.CAN-14-0806Test
http://hdl.handle.net/2078.1/245573Test

المؤلفون: Middleton, Mark R., McAlpine, Cheryl, Woodcock, Victoria K., Corrie, Pippa, Infante, Jeffry R., Steven, Neil Mathew, Evans, Thomas R Jeffry, Anthoney, Alan, Shoushtari, Alexander Noor, Hamid, Omid, Gupta, Avinash, Vardeu, Antonella, Leach, Emma, Naidoo, Revashnee, Stanhope, Sarah, Lewis, Sion, Hurst, Jacob, O’Kelly, Ita, Sznol, Mario

المصدر: Clin Cancer Res

مصطلحات موضوعية: Adult, Cytotoxicity, Immunologic, Male, Receptors, CXCR3, CD3 Complex, Recombinant Fusion Proteins, Immunity, Receptors, Antigen, T-Cell, Ataxia Telangiectasia Mutated Proteins, CD8-Positive T-Lymphocytes, Middle Aged, Article, Disease-Free Survival, Neoplasm Proteins, Chemokine CXCL10, Gene Expression Regulation, Neoplastic, Interferon-gamma, Tumor Microenvironment, Humans, Female, Melanoma, Aged, Cell Proliferation, gp100 Melanoma Antigen

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::3cd79fcc3541f956201ae1b81d927e61Test
https://europepmc.org/articles/PMC9210997Test/

المؤلفون: Woodcock, Victoria K, Clive, Sally, Wilson, Richard H., Coyle, Vicky M, Stratford, Michael R L, Folkes, Lisa K, Eastell, Richard, Barton, Claire, Jones, Paul, Kazmi-Stokes, Shamim, Turner, Helen, Halford, Sarah, Harris, Adrian L, Middleton, Mark R

المصدر: Woodcock, V K, Clive, S, Wilson, R H, Coyle, V M, Stratford, M R L, Folkes, L K, Eastell, R, Barton, C, Jones, P, Kazmi-Stokes, S, Turner, H, Halford, S, Harris, A L & Middleton, M R 2018, ' A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424 ', British Journal of Cancer, vol. 118, pp. 770-776 . https://doi.org/10.1038/bjc.2017.484Test
British Journal of Cancer

مصطلحات موضوعية: Adult, Male, Dose-Response Relationship, Drug, Maximum Tolerated Dose, ABL, Administration, Oral, Antineoplastic Agents, Middle Aged, targeted therapy, Phase I, src-Family Kinases, SDG 3 - Good Health and Well-being, Neoplasms, Clinical Study, AZD0424, Humans, Female, Proto-Oncogene Proteins c-abl, Protein Kinase Inhibitors, Src, Aged

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b9ecb37f1d088d8a64f336eb274e79b6Test
http://ora.ox.ac.uk/objects/uuidTest:

المؤلفون: Valle, Juan W, Palmer, Daniel, Jackson, Richard, Cox, Trevor, Neoptolemos, John P, Ghaneh, Paula, Rawcliffe, Charlotte L, Stocken, Deborah D, Cunningham, David, O'Reilly, Derek, Goldstein, David, Robinson, Bridget A, Karapetis, Christos, Scarfe, Andrew, Lacaine, Francois, Sand, Juhani, Izbicki, Jakob R, Mayerle, Julia, Dervenis, Christos, Oláh, Attila, Butturini, Giovanni, Lind, Pehr A, Middleton, Mark R, Anthoney, Alan, Sumpter, Kate, Carter, Ross, Büchler, Markus W., BASSI, Claudio

المساهمون: Valle, Juan W, Palmer, Daniel, Jackson, Richard, Cox, Trevor, Neoptolemos, John P, Ghaneh, Paula, Rawcliffe, Charlotte L, Bassi, Claudio, Stocken, Deborah D, Cunningham, David, O'Reilly, Derek, Goldstein, David, Robinson, Bridget A, Karapetis, Christo, Scarfe, Andrew, Lacaine, Francoi, Sand, Juhani, Izbicki, Jakob R, Mayerle, Julia, Dervenis, Christo, Oláh, Attila, Butturini, Giovanni, Lind, Pehr A, Middleton, Mark R, Anthoney, Alan, Sumpter, Kate, Carter, Ro, Büchler, Markus W.

مصطلحات موضوعية: Adenocarcinoma, Aged, Antimetabolites Antineoplastic, Carcinoma Pancreatic Ductal, Chemotherapy Adjuvant, Deoxycytidine, Disease-Free Survival. Drug Administration Schedule, Female, Fluorouracil, Humans, Male, Middle Aged, Pancreatic Neoplasms, Survival Analysis, Survival Rate

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/24419109; info:eu-repo/semantics/altIdentifier/wos/WOS:000332788900008; volume:32; issue:6; firstpage:504; lastpage:512; numberofpages:9; journal:JOURNAL OF CLINICAL ONCOLOGY; http://hdl.handle.net/11562/932941Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84898677292

الإتاحة: https://doi.org/10.1200/JCO.2013.50.7657Test
http://hdl.handle.net/11562/932941Test

المؤلفون: Zimmer, Lisa, Barlesi, Fabrice, Martinez-Garcia, Maria, Dieras, Veronique, Schellens, Jan H M, Spano, Jean-Philippe, Middleton, Mark R, Calvo, Emiliano, Paz-Ares, Luiz, Larkin, James, Pacey, Simon, Venturi, Miro, Kraeber-Bodéré, Françoise, Tessier, Jean J L, Eberhardt, Wilfried Ernst Erich, Paques, Michel, Guarin, Ernesto, Meresse, Valerie, Soria, Jean-Charles, Sub Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology

المساهمون: Sub Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology

المصدر: Clinical Cancer Research, 20(16), 4251. American Association for Cancer Research Inc.

مصطلحات موضوعية: Neuroblastoma RAS viral oncogene homolog, Adult, Male, Proto-Oncogene Proteins B-raf, Cancer Research, Colorectal cancer, Class I Phosphatidylinositol 3-Kinases, DNA Mutational Analysis, Medizin, Administration, Oral, medicine.disease_cause, Proto-Oncogene Proteins p21(ras), Phosphatidylinositol 3-Kinases, Young Adult, MEK Inhibitor RO4987655, Neoplasms, Proto-Oncogene Proteins, Oxazines, medicine, Humans, Tissue Distribution, neoplasms, Aged, Neoplasm Staging, Fluorodeoxyglucose, Aged, 80 and over, business.industry, Melanoma, MEK inhibitor, Patient Selection, Middle Aged, medicine.disease, MAP Kinase Kinase Kinases, Prognosis, Oncology, Immunology, Benzamides, Mutation, Cancer research, ras Proteins, Female, KRAS, business, Progressive disease, medicine.drug, Follow-Up Studies

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a05248c82a76f810b0b10acca6c436Test
https://dspace.library.uu.nl/handle/1874/308528Test

المؤلفون: Flaherty, Keith T, Robert, Caroline, Hersey, Peter, Nathan, Paul, Garbe, Claus, Milhem, Mohammed, Demidov, Lev V, Hassel, Jessica C, Rutkowski, Piotr, Mohr, Peter, Dummer, Reinhard, Trefzer, Uwe, Larkin, James M G, Utikal, Jochen, Dreno, Brigitte, Nyakas, Marta, Middleton, Mark R, Becker, Jürgen C, Casey, Michelle, Sherman, Laurie J, Wu, Frank S, Ouellet, Daniele, Martin, Anne-Marie, Patel, Kiran, Schadendorf, Dirk, METRIC Study Group

المساهمون: Schöffski, Patrick, U0046480, JLA

مصطلحات موضوعية: Adult, Aged, 80 and over, Antineoplastic Agents, Disease-Free Survival, Female, Humans, Intention to Treat Analysis, Kaplan-Meier Estimate, MAP Kinase Kinase 1, MAP Kinase Kinase 2, Male, Melanoma, Middle Aged, Mutation, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Pyridones, Pyrimidinones, Young Adult

العلاقة: New England Journal of Medicine vol:367 issue:2 pages:107-114; https://lirias.kuleuven.be/handle/123456789/361037Test

الإتاحة: https://lirias.kuleuven.be/handle/123456789/361037Test

المؤلفون: Watson, Amanda J, Sabharwal, Ami, Thorncroft, Mary R, McGown, Gail, Kerr, Richard, Bojanic, Stana, Soonawalla, Zahir, King, Alexandra, Miller, Andrea, Waller, Sue, Leung, Hing, Margison, Geoffrey P, Middleton, Mark R

المساهمون: Cancer Research UK Carcinogenesis Group, University of Manchester, Paterson Institute for Cancer Research, Manchester, United Kingdom.

مصطلحات موضوعية: Anticancerous Agents, Cancerous Gene Expression Regulation, Cancer, Administration, Oral, Adolescent, Adult, Aged, 80 and over, Antineoplastic Agents, Biomarkers, Pharmacological, Combined Modality Therapy, DNA Methylation, Dose-Response Relationship, Drug, Female, Gene Expression Regulation, Enzymologic, Neoplastic, Gene Silencing, Humans, Male, Middle Aged, Neoplasms, O(6)-Methylguanine-DNA Methyltransferase, Purines, Young Adult

العلاقة: Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib. 2010, 16 (2):743-9 Clin. Cancer Res.; http://hdl.handle.net/10541/109343Test; Clinical Cancer Research

الإتاحة: https://doi.org/10.1158/1078-0432.CCR-09-1389Test
http://hdl.handle.net/10541/109343Test

المؤلفون: Khan, O A, Ranson, Malcolm R, Michael, M, Olver, I, Levitt, N C, Mortimer, Peter, Watson, Amanda J, Margison, Geoffrey P, Midgley, R, Middleton, Mark R

المساهمون: CR UK Medical Oncology Unit, Churchill Hospital, Old Road, Oxford OX3 7LJ, UK.

مصطلحات موضوعية: Colorectal Cancer, DNA Repair, Clinical Trial, Adult, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Colorectal Neoplasms, Dacarbazine, Disease Progression, Female, Humans, Male, Middle Aged, Neoplasm Staging, Purines, Treatment Failure

العلاقة: A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer. 2008, 98 (10):1614-8 Br. J. Cancer; http://hdl.handle.net/10541/66160Test; British Journal of Cancer

الإتاحة: https://doi.org/10.1038/sj.bjc.6604366Test
http://hdl.handle.net/10541/66160Test