المؤلفون: Jenny Joutsen, Fang Cheng, Mikael C. Puustinen, Johanna K. Björk, Lea Sistonen, Malin Åkerfelt, Matthias Nees

المصدر: Björk, J K, Åkerfelt, M, Joutsen, J, Puustinen, M C, Cheng, F, Sistonen, L & Nees, M 2016, ' Heat-shock factor 2 is a suppressor of prostate cancer invasion ', Oncogene, vol. 35, no. 14, pp. 1770-84 . https://doi.org/10.1038/onc.2015.241Test
Oncogene

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Biology, medicine.disease_cause, ta3111, Metastasis, Mice, RHO signalling, 03 medical and health sciences, Prostate cancer, SDG 3 - Good Health and Well-being, Cell Line, Tumor, Biomarkers, Tumor, Genetics, medicine, Animals, Humans, metastasis, Neoplasm Invasiveness, Neoplasm Metastasis, HSF1, Cell adhesion, Molecular Biology, Heat-Shock Proteins, Actin, ta1184, ta1182, Prostatic Neoplasms, Cancer, Cell Differentiation, prostate cancer, medicine.disease, Actin cytoskeleton, ta3122, Xenograft Model Antitumor Assays, Cell biology, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Tumor progression, Original Article, Neoplasm Grading, Carcinogenesis, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1086c344a0abcd5eeff393db512281fdTest
http://juuli.fi/Record/0006694915Test

المؤلفون: Hannu-Pekka Schukov, Matthias Nees, Janne Heikkilä, Malin Åkerfelt, Sean Robinson, Raija Sormunen, Neslihan Bayramoglu, Johannes Virtanen, Juho Kannala, Mika Kaakinen, Mervi Toriseva, Ville Härmä, Lauri Eklund

المساهمون: Turku Centre for Biotechnology, University of Turku-Åbo Academy University, University of Turku, Laboratoire de Biologie à Grande Échelle (BGE - UMR S1038), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), VTT Technical Research Centre of Finland (VTT), Machine Vision Group (MVG), University of Oulu, Center for Machine Vision Research (CMV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

المصدر: Oncotarget
Oncotarget, Impact journals, 2015, 6 (30), ⟨10.18632/oncotarget.5046⟩
Oncotarget, 2015, 6 (30), ⟨10.18632/oncotarget.5046⟩
Åkerfelt, M, Bayramoglu, N, Robinson, S, Toriseva, M, Schukov, H-P, Härmä, V, Virtanen, J, Sormunen, R, Kaakinen, M, Kannala, J, Eklund, L, Heikkilä, J & Nees, M 2015, ' Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention ', Oncotarget, vol. 6, no. 30, pp. 30035-30056 . https://doi.org/10.18632/oncotarget.5046Test

مصطلحات موضوعية: Male, [SDV]Life Sciences [q-bio], focal adhesion kinase (FAK), Cell Culture Techniques, Cell Communication, Prostate cancer, 0302 clinical medicine, Cell Movement, Tumor Microenvironment, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, Microscopy, Confocal, 3D co-culture, invasion, University hospital, 3. Good health, Oncology, Cell Tracking, Research centre, 030220 oncology & carcinogenesis, Collagen, Algorithms, Research Paper, Cancer associated fibroblast, ta3111, Models, Biological, Time-Lapse Imaging, Cell Line, 03 medical and health sciences, Microscopy, Electron, Transmission, SDG 3 - Good Health and Well-being, Cell Line, Tumor, medicine, Humans, Tumor growth, Tumor stroma, Protein Kinase Inhibitors, Cell Proliferation, 030304 developmental biology, ta113, Tumor histology, Tumor microenvironment, cancer associated fibroblast (CAF), business.industry, phenotypic screening, ta1182, Granulocyte-Macrophage Colony-Stimulating Factor, Prostatic Neoplasms, Fibroblasts, ta3122, medicine.disease, Coculture Techniques, Focal Adhesion Protein-Tyrosine Kinases, Cancer research, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93326a6d15c89889a4ac7e1d2f45097Test
https://doi.org/10.18632/oncotarget.5046Test

المؤلفون: Malin Åkerfelt, Matthias Nees, Jonathan Waxman, Irantzu Gorroño-Etxebarria, Virginia Murillo-Garzón, Mikael C. Puustinen, James Carton, Lea Sistonen, Robert M. Kypta

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Male, Frizzled, General Physics and Astronomy, Smad Proteins, Prostate cancer, Transforming Growth Factor beta, Neoplasm Metastasis, lcsh:Science, WNT/BETA-CATENIN, Multidisciplinary, Wnt signaling pathway, TGF-BETA, prostate cancer, CONVERGENT EXTENSION MOVEMENTS, Multidisciplinary Sciences, embryonic structures, Science & Technology - Other Topics, Signal transduction, Signal Transduction, Epithelial-Mesenchymal Transition, animal structures, Science, NONCANONICAL WNT, Receptors, Cell Surface, MAJOR ROLE, Biology, General Biochemistry, Genetics and Molecular Biology, Article, MECHANISMS, 03 medical and health sciences, Wnt, Cell Line, Tumor, TGF beta signaling pathway, MD Multidisciplinary, medicine, Humans, XENOPUS-LAEVIS, Neoplasm Invasiveness, Epithelial–mesenchymal transition, Gene Silencing, MESENCHYMAL TRANSITION, Science & Technology, Activating Transcription Factor 2, Cell growth, Prostatic Neoplasms, General Chemistry, Transforming growth factor beta, medicine.disease, Wnt Proteins, 030104 developmental biology, CELLS, biology.protein, Cancer research, lcsh:Q, sense organs, TRANSCRIPTIONAL ACTIVATION, Receptors, Transforming Growth Factor beta

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098e23af2a5c7228f627f020758dfaf0Test
http://hdl.handle.net/10044/1/57704Test

المؤلفون: Jesse Mattsson, Matthias Nees, Natalia Tong Ochoa, Riina Minna Väänänen, Terhi Tallgren, Peter J. Boström, Anders Bjartell, Pekka Taimen, Saeid Alinezhad, Kim Pettersson, Malin Åkerfelt, Yifeng Li

المصدر: PLoS ONE, Vol 11, Iss 5, p e0155901 (2016)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Male, rho GTP-Binding Proteins, Candidate gene, Gene Expression, lcsh:Medicine, Bioinformatics, Biochemistry, Metastasis, Prostate cancer, 0302 clinical medicine, Prostate, Medicine and Health Sciences, Small interfering RNAs, ta318, Organ Cultures, Reproductive System Procedures, lcsh:Science, Multidisciplinary, Prostate Cancer, Prostate Diseases, Middle Aged, Radical Prostatectomy, 3. Good health, Gene Expression Regulation, Neoplastic, Nucleic acids, Organoids, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, RNA Interference, Biological Cultures, Anatomy, Research Article, PCA3, Calcium Channels, L-Type, Urology, Surgical and Invasive Medical Procedures, Biology, Research and Analysis Methods, Transfection, 03 medical and health sciences, Exocrine Glands, Coenzyme A Ligases, medicine, Biomarkers, Tumor, Genetics, Gene silencing, Humans, Non-coding RNA, Molecular Biology Techniques, Molecular Biology, Aged, Homeodomain Proteins, Prostatectomy, ta3126, Biology and life sciences, Surgical Excision, lcsh:R, Cancer, Prostatic Neoplasms, Correction, Cancers and Neoplasms, medicine.disease, Gene regulation, Genitourinary Tract Tumors, 030104 developmental biology, Cancer cell, 1-Alkyl-2-acetylglycerophosphocholine Esterase, RNA, Prostate Gland, lcsh:Q, Laminin, Biomarkers, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f221120cae865b6962c0c530616481Test
http://europepmc.org/articles/PMC4873225?pdf=renderTest

المؤلفون: Lan, Yu, Mervi, Toriseva, Miikka, Tuomala, Heikki, Seikkula, Teresa, Elo, Johanna, Tuomela, Markku, Kallajoki, Tuomas, Mirtti, Pekka, Taimen, Peter J, Boström, Kalle, Alanen, Martti, Nurmi, Matthias, Nees, Pirkko, Härkönen

المصدر: International journal of cancer. 139(1)

مصطلحات موضوعية: Aged, 80 and over, Male, Prostatectomy, Prostatic Neoplasms, Prognosis, Disease-Free Survival, Fibroblast Growth Factors, Gene Expression Regulation, Neoplastic, Tissue Array Analysis, Biomarkers, Tumor, Humans, RNA, Messenger, Neoplasm Recurrence, Local, Aged

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::0c21a04600f7515faf6671493969cf78Test
https://pubmed.ncbi.nlm.nih.gov/26891277Test

المؤلفون: Matthias Nees, Juha Rantala, Olli Kallioniemi, Mari Björkman

المصدر: Björkman, M, Rantala, J K, Nees, M & Kallioniemi, O 2010, ' Epigenetics of prostate cancer and the prospect of identification of novel drug targets by RNAi screening of epigenetic enzymes ', Epigenomics, vol. 2, no. 5, pp. 683-689 . https://doi.org/10.2217/epi.10.48Test

مصطلحات موضوعية: Male, Chromatin Immunoprecipitation, Cancer Research, Microarray, cell microarray technology, Computational biology, Disease, Biology, Bioinformatics, high-throughput screening, Epigenesis, Genetic, Histones, 03 medical and health sciences, Prostate cancer, PrCa, Drug Delivery Systems, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Genetics, medicine, Humans, Epigenetics, RNA, Small Interfering, Gene Library, 030304 developmental biology, Epigenomics, 0303 health sciences, epigenetics, Prostatic Neoplasms, Cancer, Sequence Analysis, DNA, Epigenome, DNA Methylation, Microarray Analysis, medicine.disease, prostate cancer, Enzymes, High-Throughput Screening Assays, 3. Good health, Receptors, Androgen, 030220 oncology & carcinogenesis, siRNA, CpG Islands, HTS, Chromatin immunoprecipitation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e78248139ce0696de7874b02ab8ec34Test
https://doi.org/10.2217/epi.10.48Test

المؤلفون: Elisa Kaivanto, Pasi Halonen, Kristiina Iljin, Olli Kallioniemi, Matthias Nees, Mari Björkman, Henri Sara

المصدر: Björkman, M, Iljin, K, Halonen, P, Sara, H, Kaivanto, E, Nees, M & Kallioniemi, O 2008, ' Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer ', International Journal of Cancer, vol. 123, no. 12, pp. 2774-2781 . https://doi.org/10.1002/ijc.23885Test

مصطلحات موضوعية: Male, Cancer Research, Oncogene Proteins, Fusion, genetic structures, Pyridines, Apoptosis, Hydroxamic Acids, Polymerase Chain Reaction, Flutamide, Tosyl Compounds, Androgen deprivation therapy, chemistry.chemical_compound, Prostate cancer, HDAC inhibitors, Antineoplastic Combined Chemotherapy Protocols, Anilides, Enzyme Inhibitors, Protein Synthesis Inhibitors, Drug Synergism, prostate cancer, Up-Regulation, Gene Expression Regulation, Neoplastic, Oncology, Receptors, Androgen, ERG, Benzamides, Epigenetic therapy, medicine.drug, medicine.medical_specialty, Antineoplastic Agents, Hormonal, medicine.drug_class, Blotting, Western, Biology, Gene Expression Regulation, Enzymologic, SDG 3 - Good Health and Well-being, Cell Line, Tumor, Internal medicine, Nitriles, Biomarkers, Tumor, medicine, Humans, Gene Silencing, Prostatic Neoplasms, Androgen Antagonists, Gene signature, medicine.disease, Androgen, eye diseases, Histone Deacetylase Inhibitors, Androgen receptor, Endocrinology, Trichostatin A, chemistry, Cancer research, sense organs, AR

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9e5fecc5384943013a6dfe5ab91199Test
https://doi.org/10.1002/ijc.23885Test

المؤلفون: Mervi Toriseva, Laurent Guyon, Matthias Nees, Sean Robinson, Jaakko Nevalainen, Malin Åkerfelt

المساهمون: University of Turku, Laboratoire de Biologie à Grande Échelle (BGE - UMR S1038), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Tampere School of Public Health, Turku Centre for Biotechnology, University of Turku-Åbo Academy University, Medical Biotechnology, VTT Technical Research Centre of Finland (VTT), Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Cancer Research Institute Ghent (CRIG), Ghent University [Belgium] (UGENT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Terveystieteiden yksikkö - School of Health Sciences, University of Tampere

المصدر: Robinson, S, Guyon, L, Nevalainen, J, Toriseva, M, Åkerfelt, M & Nees, M 2015, ' Segmentation of image data from complex organotypic 3D models of cancer tissues with Markov random fields ', PLoS ONE, vol. 10, no. 12, e143798 . https://doi.org/10.1371/journal.pone.0143798Test
PLoS ONE
PLoS ONE, Public Library of Science, 2015, 10 (12), ⟨10.1371/journal.pone.0143798⟩
PLoS ONE, Public Library of Science, 2015, 10 (12), pp.e0143798. ⟨10.1371/journal.pone.0143798⟩
PLoS ONE, 2015, 10 (12), ⟨10.1371/journal.pone.0143798⟩
PLoS ONE, Vol 10, Iss 12, p e0143798 (2015)

مصطلحات موضوعية: Male, Cell type, Biolääketieteet - Biomedicine, [SDV]Life Sciences [q-bio], ta220, lcsh:Medicine, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, 02 engineering and technology, Biology, Bioinformatics, Models, Biological, 03 medical and health sciences, 3D cell culture, Imaging, Three-Dimensional, SDG 3 - Good Health and Well-being, Cell Line, Tumor, Image Interpretation, Computer-Assisted, 0202 electrical engineering, electronic engineering, information engineering, Humans, Entropy (information theory), Segmentation, lcsh:Science, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, ta113, ta112, 0303 health sciences, Ground truth, Multidisciplinary, Random field, Markov chain, business.industry, lcsh:R, ta111, ta1182, Prostatic Neoplasms, Pattern recognition, Image segmentation, ta3122, Coculture Techniques, Markov Chains, Microscopy, Fluorescence, Multiphoton, lcsh:Q, 020201 artificial intelligence & image processing, Artificial intelligence, business, Research Article

وصف الملف: fulltext

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98802e75139190a45c326f6956c10bb7Test
https://cris.vtt.fi/en/publications/18071a24-2909-490d-9da8-99c973625faaTest

المؤلفون: Kirsi-Marja Oksman-Caldentey, Ville Härmä, Raisa Haavikko, Heiko Rischer, Matthias Nees, Hannu-Pekka Schukov, Johannes Virtanen, Vânia M. Moreira, Enkhee Purev, Ilmari Ahonen, Jari Yli-Kauhaluoma, Sami Alakurtti

المساهمون: Faculty of Pharmacy, Jari Yli-Kauhaluoma / Principal Investigator, Drug Discovery, Division of Pharmaceutical Chemistry and Technology, Pharmaceutical Design and Discovery group, Drug Research Program

المصدر: Härmä, V, Haavikko, R, Virtanen, J, Ahonen, I, Schukov, H-P, Alakurtti, S, Purev, E, Rischer, H, Yli-Kauhaluoma, J, Moreira, V M, Nees, M & Oksman-Caldentey, K-M 2015, ' Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development ', PLoS ONE, vol. 10, no. 5, e0126111 . https://doi.org/10.1371/journal.pone.0126111Test
PLoS ONE, Vol 10, Iss 5, p e0126111 (2015)
PLoS ONE

مصطلحات موضوعية: Male, EXPRESSION, MIGRATION, Science, Motility, Biology, Cell morphology, ta3111, 3RD-DIMENSION, RS, CULTURE, Prostate cancer, CYP17 INHIBITORS, SDG 3 - Good Health and Well-being, TUMOR SPHEROIDS, Cell Line, Tumor, LNCaP, medicine, Humans, PLASTICITY, Mitosis, Cell Proliferation, Multidisciplinary, Cell growth, ta1182, Epithelial Cells, medicine.disease, Actin cytoskeleton, Triterpenes, 3. Good health, Cell biology, Gene Expression Regulation, Neoplastic, MODEL, Prostatic Neoplasms, Castration-Resistant, Cell culture, 317 Pharmacy, DISCOVERY, ACID, Androgens, Medicine, Protein Kinases, Signal Transduction, Research Article

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc19703b1a804cbf4b9dc5840bc95e23Test
https://cris.vtt.fi/en/publications/63da1049-9218-45d4-bc9b-feed76123726Test

المؤلفون: Giovanna Angelini, Adriana Amaro, Ulrich Pfeffer, Anna Maria Gallina, Matthias Nees, Alessia Isabella Esposito, Adriana Albini

المساهمون: Amaro, A, Esposito, A, Gallina, A, Nees, M, Angelini, G, Albini, A, Pfeffer, U

المصدر: Amaro, A, Esposito, A I, Gallina, A, Nees, M, Angelini, G, Albini, A & Pfeffer, U 2014, ' Validation of proposed prostate cancer biomarkers with gene expression data: a long road to travel ', Cancer and Metastasis Reviews, vol. 33, no. 2-3, pp. 657-671 . https://doi.org/10.1007/s10555-013-9470-4Test
Cancer Metastasis Reviews

مصطلحات موضوعية: PCA3, Male, Cancer Research, Prognosi, Reproducibility of Result, Datasets as Topic, Disease, Bioinformatics, Article, Prostate cancer, PSA, SDG 3 - Good Health and Well-being, Prostate, medicine, Biomarkers, Tumor, Cluster Analysis, Humans, FLNC, prognostic signature, Multivariate Analysi, multivariae model, Cluster Analysi, business.industry, Gene Expression Profiling, Cancer, Prostatic Neoplasms, Reproducibility of Results, Biomarker, medicine.disease, Prognosis, prostate cancer, Gene expression profiling, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Oncology, Meta-analysis, Prostatic Neoplasm, Multivariate Analysis, Multivariate model, Neoplasm Grading, business, Biomarkers, Biomakers, Human

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34ad6b1506036f92ba62d96dfa63fddTest
https://cris.vtt.fi/en/publications/95dcf428-df5a-489d-82da-6c2b47b28a3cTest