L-methionine-induced alterations in molecular signatures in MCF-7 and LNCaP cancer cells
| العنوان: | L-methionine-induced alterations in molecular signatures in MCF-7 and LNCaP cancer cells |
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| المؤلفون: | Maarten C. Bosland, Simon Lin, Maximo A. Benavides, Dong Hu, Marie K. Baraoidan, Annette Bruno, Kirby I. Bland, William E. Grizzle, Wancai Yang, Pan Du |
| المصدر: | Journal of Cancer Research and Clinical Oncology. 137:441-453 |
| بيانات النشر: | Springer Science and Business Media LLC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Cancer Research, medicine.medical_specialty, Cell Survival, Breast Neoplasms, Biology, Article, chemistry.chemical_compound, Methionine, Cell Line, Tumor, Internal medicine, Gene expression, LNCaP, medicine, Humans, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Microarray analysis techniques, Cell Cycle, Prostatic Neoplasms, General Medicine, Cell cycle, Molecular biology, Gene Expression Regulation, Neoplastic, Endocrinology, Oncology, MCF-7, chemistry, Cell culture, Cancer cell, Female |
| الوصف: | Methionine inhibits proliferation of breast and prostate cancer cells. Here, we determined the influence of L-methionine on functional molecular signatures in these cell lines. MCF-7 and LNCaP cells were treated with L-methionine (5 mg/ml) for 72 h. Changes in molecular signatures of these cells were examined by microarray analysis of 15,814 probes in triplicate experiments. In LNCaP cells, 325 genes were up-regulated by methionine, and 517 genes down-regulated. In MCF-7 cells, 86 genes were up-regulated and 135 genes down-regulated. Ninety-eight genes were regulated in the same direction by methionine in both cells lines, and five other genes were changed in expression in opposite directions. Several of the up-regulated genes encode proteins involved in cellular redox regulation, suggesting that methionine may enhance antioxidant mechanisms. Many of the down-regulated genes belong to protein kinase families that may be related to the anti-proliferative effects of methionine on breast and prostate cancer cells. |
| تدمد: | 1432-1335 0171-5216 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f062a10f5afbb3d2dc82e14889ca4fe3Test https://doi.org/10.1007/s00432-010-0897-5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f062a10f5afbb3d2dc82e14889ca4fe3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321335 01715216 |
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