المؤلفون: Claudio Maria Mastroianni, Simona Coco, Francesco Pugliese, Carlo Catalano, Giorgio Maria Masci, Chiara Andreoli, Marco Francone, Ombretta Turriziani, Lucia Manganaro, Francesco Alessandri, Maria Chiara Colaiacomo, Franco Iafrate, Maria Antonella Zingaropoli, Valeria Panebianco, Francesco Cilia, Paolo Ricci, Maria Rosa Ciardi

المصدر: European Radiology

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Multivariate analysis, Pneumonia, Viral, Disease, Severity of Illness Index, covid-19, pneumonia, severe acute respiratory syndrome coronavirus 2, tomography, x-ray computed, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, Internal medicine, Severity of illness, medicine, Severe acute respiratory syndrome coronavirus 2, Humans, Radiology, Nuclear Medicine and imaging, Stage (cooking), Pandemics, Lung, Survival analysis, Neuroradiology, Retrospective Studies, medicine.diagnostic_test, business.industry, SARS-CoV-2, Tomography, X-ray computed, COVID-19, Retrospective cohort study, Interventional radiology, General Medicine, Pneumonia, Middle Aged, Prognosis, Italy, Radiology Nuclear Medicine and imaging, 030220 oncology & carcinogenesis, Chest, Female, Radiology, business, Coronavirus Infections, Respiratory Insufficiency

الوصف: To correlate a CT-based semi-quantitative score of pulmonary involvement in COVID-19 pneumonia with clinical staging of disease and laboratory findings. We also aimed to investigate whether CT findings may be predictive of patients’ outcome. From March 6 to March 22, 2020, 130 symptomatic SARS-CoV-2 patients were enrolled for this single-center analysis and chest CT examinations were retrospectively evaluated. A semi-quantitative CT score was calculated based on the extent of lobar involvement (0:0%; 1, 75%; range 0–5; global score 0–25). Data were matched with clinical stages and laboratory findings. Survival curves and univariate and multivariate analyses were performed to evaluate the role of CT score as a predictor of patients’ outcome. Ground glass opacities were predominant in early-phase (≤ 7 days since symptoms’ onset), while crazy-paving pattern, consolidation, and fibrosis characterized late-phase disease (> 7 days). CT score was significantly higher in critical and severe than in mild stage (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4f36f981ff3cdc761bbc78e527e8e9Test
http://europepmc.org/articles/PMC7334627Test

المؤلفون: Maria I. Argyropoulou, Lucia Manganaro, Miriam Dolciami, Giada Ercolani, Carlo Catalano, Athina C Tsili

المصدر: Andrology

مصطلحات موضوعية: Male, medicine.medical_specialty, endocrine system, endocrine system diseases, Urology, Endocrinology, Diabetes and Metabolism, Physical examination, Acute scrotum, Review Article, testis, urologic and male genital diseases, Testicular Diseases, Male infertility, Special Issue: Imaging in Andrology, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Scrotum, medicine, Humans, In patient, Orchiectomy, Review Articles, Societies, Medical, 030219 obstetrics & reproductive medicine, medicine.diagnostic_test, Genitourinary system, business.industry, urogenital system, Magnetic resonance imaging, testicular neoplasms, medicine.disease, multiparametric magnetic resonance imaging, Magnetic Resonance Imaging, medicine.anatomical_structure, Reproductive Medicine, Practice Guidelines as Topic, Radiology, business

الوصف: Background Multiparametric MRI (mpMRI) of the scrotum has been established as a useful second-line diagnostic tool for the investigation of scrotal diseases. Recently, recommendations on clinical indications for scrotal MRI were issued by the Scrotal and Penile Imaging Working Group of the European Society of Urogenital Radiology. Objective To update current research on when to ask for an MRI of the scrotum. Methods PubMed database was searched for original articles and reviews published during 2010-2021. Results Eighty-three articles fulfilled the search criteria. Scrotal MRI is mainly recommended after inconclusive US findings or inconsistent with the clinical examination and should be asked in the following cases: differentiation between intratesticular and paratesticular lesions (in rare cases of uncertain US findings), characterization of paratesticular and intratesticular lesions (when US findings are indeterminate), discrimination between germ cell and sex cord-stromal testicular tumors, local staging of testicular malignancies (in patients planned for testis-sparing surgery), differentiation between seminomas and non-seminomatous tumors (when immediate chemotherapy is planned and orchiectomy is delayed), assessment of acute scrotum and scrotal trauma (rarely needed, in cases of non-diagnostic US findings) and detection and localization of undescended testes (in cases of inconlusive US findings). Although preliminary data show promising results in the evaluation of male infertility, no established role for mpMRI still exists. Conclusion Multiparametric MRI of the scrotum, by assessing morphologic and functional data represents a valuable problem-solving tool, helping to improve our understanding on the nature of scrotal pathology and the process of spermatogenesis. The technique may improve patient care and reduce the number of unnecessary surgical procedures.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1848113d0f233c4d8bb2efca666b9589Test
https://pubmed.ncbi.nlm.nih.gov/33964115Test

المؤلفون: Stefano Bracci, Miriam Dolciami, Paolo Ricci, Antonella Izzo, Giulia d'Amati, Lucia Manganaro, Claudio Trobiani, Angelina Pernazza

المصدر: La Radiologia Medica

مصطلحات موضوعية: medicine.medical_specialty, Chest Radiology, Population, Locally advanced, chest CT, lung cancer, PD-L1 expression, texture analysis, aged, B7-H1 antigen, carcinoma, non-small-cell lung, female, humans, lung neoplasms, male, middle aged, neoplasm staging, predictive value of tests, retrospective studies, tomography, x-ray computed, tomography, carcinoma, Logistic regression, Carcinoma, Non-Small-Cell Lung, medicine, Radiology, Nuclear Medicine and imaging, Lung cancer, education, Neuroradiology, x-ray computed, education.field_of_study, Receiver operating characteristic, business.industry, Area under the curve, General Medicine, medicine.disease, non-small-cell lung, Pd l1 expression, Radiology, Tomography, X-Ray Computed, business

الوصف: Purpose The assessment of Programmed death-ligand 1 (PD-L1) expression has become a game changer in the treatment of patients with advanced non-small cell lung cancer (NSCLC). We aimed to investigate the ability of Radiomics applied to computed tomography (CT) in predicting PD-L1 expression in patients with advanced NSCLC. Methods By applying texture analysis, we retrospectively analyzed 72 patients with advanced NSCLC. The datasets were randomly split into a training cohort (2/3) and a validation cohort (1/3). Forty radiomic features were extracted by manually drawing tumor volumes of interest (VOIs) on baseline contrast-enhanced CT. After selecting features on the training cohort, two predictive models were created using binary logistic regression, one for PD-L1 values ≥ 50% and the other for values between 1 and 49%. The two models were analyzed with ROC curves and tested in the validation cohort. Results The Radiomic Score (Rad-Score) for PD-L1 values ≥ 50%, which consisted of Skewness and Low Gray-Level Zone Emphasis (GLZLM_LGZE), presented a cut-off value of − 0.745 with an area under the curve (AUC) of 0.811 and 0.789 in the training and validation cohort, respectively. The Rad-Score for PD-L1 values between 1 and 49% consisted of Sphericity, Skewness, Conv_Q3 and Gray Level Non-Uniformity (GLZLM_GLNU), showing a cut-off value of 0.111 with AUC of 0.763 and 0.806 in the two population, respectively. Conclusion Rad-Scores obtained from CT texture analysis could be useful for predicting PD-L1 expression and guiding the therapeutic choice in patients with advanced NSCLC.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a095ce08cedac481ec353377b4cdc87Test
https://hdl.handle.net/11573/1657736Test

المؤلفون: Emanuela Anastasi, Valentina Viggiani, Lucia Manganaro, Sara Tartaglione, Teresa Granato, Serena Rita Zarrillo, Cinzia Marchese, Antonio Angeloni, Irene Pecorella

المصدر: Biochemia Medica
Volume 29
Issue 2

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Clinical Biochemistry, pancreatic cancer, PIVKA-II, CA 19-9, CA 242, CEA, Enzyme-Linked Immunosorbent Assay, Pilot Projects, Vitamin k, Gastroenterology, Serology, 03 medical and health sciences, 0302 clinical medicine, Carcinoembryonic antigen, Interquartile range, Pancreatic cancer, Internal medicine, medicine, Biomarkers, Tumor, Humans, Protein Precursors, Aged, Aged, 80 and over, biology, Receiver operating characteristic, business.industry, Biochemistry (medical), Original Articles, Middle Aged, medicine.disease, 3. Good health, Pancreatic Neoplasms, ROC Curve, 030220 oncology & carcinogenesis, Luminescent Measurements, biology.protein, Biomarker (medicine), 030211 gastroenterology & hepatology, Female, Prothrombin, business, Biomarkers

الوصف: Introduction: Protein induced by vitamin K absence II (PIVKA-II) is an abnormal prothrombin increased in gastrointestinal malignancy. We aimed to evaluate PIVKA-II in comparison to established pancreatic cancer (PC) biomarkers (CA 19-9, carcinoembryonic antigen (CEA) and CA 242) measured in PC patients and in patients with benign pancreatic diseases. Materials and methods: We studied 26 PC patients (Group 1) and 20 patients with benign pancreatic diseases (Group 2). PIVKA-II and CEA were measured by chemiluminescent enzyme immunoassay method (CLEIA) on LUMIPULSE G1200 (Fujirebio-Europe, Gent, Belgium), CA 19-9 and CA 242 were measured by ELSA (CisBio Bioassays, Codolet, France) and EIA (Fujirebio Diagnostics AB, Göteborg, Sweden), respectively. Receiver operating characteristic (ROC) analysis was performed to assess biomarkers’ diagnostic characteristics in both groups. Results: Median and interquartile range (IQR) in Group 1 and Group 2 were: 1749.0 (320.2 – 3921.0) vs. 31.0 (23.0 – 43.0) mAU/mL (P < 0.001) for PIVKA-II, 260.0 (158.7 – 272.0) vs. 45.2 (9.0 – 58.0) U/mL (P = 0.034) for CA 19-9, 104.0 (30.2 – 150.0) vs. 7.2 (4.8 – 26.0) U/mL (P < 0.050) for CA 242, 9.4 (5.3 – 37.5) vs. 4.5 (1.8 – 7.0) ng/mL (P = 0.021) for CEA. Areas under the ROC curve of PIVKA-II, CA 19-9, CA 242, CEA were 0.86 (95% CI: 0.71 – 1.00), 0.58 (95% CI: 0.38 – 0.78), 0.73 (95% CI: 0.54 – 0.92), 0.64 (95% CI: 0.44 – 0.85), respectively. Conclusions: PIVKA-II is significantly higher in PC than in benign pancreatic diseases. PIVKA-II shows a rather good diagnostic performance compared to CA 19-9, CEA and CA242, thus its determination could help PC management.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d7adc4c965061f53b45c673eb0fa94Test
http://europepmc.org/articles/PMC6559614Test

المؤلفون: Lucia, Manganaro, Silvia, Bernardo, Corrado, De Vito, Amanda, Antonelli, Enrica, Marchionni, Valeria, Vinci, Matteo, Saldari, Letizia, Di Meglio, Antonella, Giancotti, Evelina, Silvestri, Carlo, Catalano, Antonio, Pizzuti

مصطلحات موضوعية: Adult, Male, Gestational Age, Prognosis, Magnetic Resonance Imaging, Cross-Sectional Studies, fetal MRI, Pregnancy, isolated and non-isolated forms, Prenatal Diagnosis, Humans, cross-sectional study, Abnormalities, Multiple, Female, Agenesis of Corpus Callosum, corpus callosum dysgenesis, Retrospective Studies

الوصف: The aims of this study were to characterize isolated and non-isolated forms of corpus callosum dysgenesis (CCD) at fetal magnetic resonance imaging (MRI) and to identify early predictors of associated anomalies.We retrospectively analyzed 104 fetuses with CCD undergoing MRI between 2006 and 2016. Corpus callosum, cavum septi pellucidi, biometry, presence of ventriculomegaly, gyration anomalies, cranio-encephalic abnormalities and body malformations were evaluated. Results of genetic tests were also recorded.At MRI, isolated CCD was 26.9%, the rest being associated to other abnormalities. In the isolated group, median gestational age at MRI was lower in complete agenesis than in hypoplasia (22 vs 28 weeks). In the group with additional findings, cortical dysplasia was the most frequently associated feature (P = 0.008), with a more frequent occurrence in complete agenesis (70%) versus other forms; mesial frontal lobes were more often involved than other cortical regions (P = 0.006), with polymicrogyria as the most frequent cortical malformation (40%). Multivariate analysis confirmed the association between complete agenesis and cortical dysplasia (odds ratio = 7.29, 95% confidence interval 1.51-35.21).CCD is often complicated by other intra-cranial and extra-cranial findings (cortical dysplasias as the most prevalent) that significantly affect the postnatal prognosis. The present study showed CCD with associated anomalies as more frequent than isolated (73.1%). In isolated forms, severe ventriculomegaly was a reliable herald of future appearance of associated features. © 2016 John WileySons, Ltd.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1a6fb2c14c1e2640b61e82890a6adcc4Test
http://hdl.handle.net/11573/958193Test

المؤلفون: Eugenio Martorana, Valeria Rondoni, Michele Scialpi, Luis H Ros, Ahmed Eissa, Maria Antonietta Mazzei, L. Bevilacqua, Giampaolo Bianchi, Irene Escartín Martínez, Alfredo D’Andrea, Lucia Manganaro, Ahmed El Sherbiny, Michele Milizia

مصطلحات موضوعية: Adenoma, Male, Pathology, medicine.medical_specialty, renal cell carcinoma, differential diagnosis, oncocytoma, triphasic MDCT, Adenoma, Oxyphilic, Carcinoma, Renal Cell, Diagnosis, Differential, Female, Humans, Kidney Neoplasms, Middle Aged, Retrospective Studies, Multidetector Computed Tomography, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Medicine (all), Renal cell carcinoma, Multidetector computed tomography, Diagnosis, Carcinoma, medicine, Oncocytoma, business.industry, Oxyphilic, Renal Cell, General Medicine, medicine.disease, 030220 oncology & carcinogenesis, Differential, Treatment strategy, Differential diagnosis, business

الوصف: Introduction Although differentiation between benign and malignant small renal tumors (≤4 cm) is still difficult, it is a demand for decision making and determining the treatment strategy. Our aim is to evaluate the role of multidetector row computed tomography (MDCT) in the differentiation of small renal clear cell carcinoma (RCC) and renal oncocytoma (RO). Methods We reviewed triphasic computed tomographic (CT) scans performed in 43 patients diagnosed with RCC (n = 23) and RO (n = 21). After an unenhanced CT phase of the upper abdomen, triple-phase acquisition included a cortico-medullary phase (CMP), a nephrographic phase (NP), and a pyelographic phase (PP), and lesions were evaluated both qualitatively and quantitatively. Results RCCs were hypervascular in 13 cases and hypovascular in 10 cases, while ROs were hypervascular in nine cases and hypovascular in 12 cases. Mean attenuation values (MAVs) for hypervascular RCCs and hypervascular ROs on unenhanced examination were 34.0 ± 7.1 and 31.3 ± 8.1 HU, respectively. Enhancement in CMP was 173.1 ± 45.2 HU for RCCs and 151.1 ± 36.0 HU for ROs and a gradual wash-out in NP (148.8 ± 34.3 and 137.1 ± 33.9 HU for RCCs and ROs, respectively) and in PP (98.2 ± 36.0 HU for RCCs and 79.4 ± 21.5 HU for ROs) was observed. MAV for hypovascular RCCs and hypovascular ROs on unenhanced examination were 32.4 ± 12.0 and 28.9 ± 8.0 HU, respectively. Both hypovascular RCCs and ROs showed a statistically significant difference in each post contrastographic phase. Conclusions Absolute attenuation and the quantitative amount of the enhancement were not strong predictors for RO and RCC differentiation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0332a3ad31960afd71a330793045689Test
http://hdl.handle.net/11365/1042119Test

المؤلفون: Paola De Liso, Antonella Giancotti, Lucia Manganaro, Silvia Bernardo, Enrica Marchionni, Antonio Pizzuti, Alberto Spalice, Sabrina Prudente

المصدر: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 21(3)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Pathology, medicine.medical_specialty, Prenatal diagnosis, Neuroimaging, 03 medical and health sciences, 0302 clinical medicine, Seizures, medicine, Humans, Exome sequencing, Fetus, Brain Diseases, NAV1.2 Voltage-Gated Sodium Channel, medicine.diagnostic_test, business.industry, Pachygyria, Infant, Newborn, Magnetic resonance imaging, General Medicine, Cortical dysplasia, medicine.disease, Magnetic Resonance Imaging, Malformations of Cortical Development, 030104 developmental biology, Carbamazepine, Phenotype, Dysplasia, Pediatrics, Perinatology and Child Health, Mutation, Female, Neurology (clinical), business, 030217 neurology & neurosurgery, Infant, Premature, Ventriculomegaly

الوصف: We present an atypical association of SCN2A epileptic encephalopathy with severe cortical dysplasia. SCN2A mutations are associated with epileptic syndromes from benign to extremely severe in absence of such macroscopic brain findings. Prenatal MRI (Magnetic Resonance Imaging) in a 32 weeks fetus, with US (Ultrasonography) diagnosis of isolated ventriculomegaly showed CNS (Central Nervous System) dysplasia characterized by lack of differentiation between cortical and subcortical layers, pachygyria and corpus callosum dysgenesis. Postnatal MRI confirmed the prenatal findings. On day 6 the baby presented a focal status epilepticus, partially controlled by phenobarbital, phenytoin, and levetiracetam. After three weeks a moderate improvement in seizure control has been achieved with carbamazepine. Exome sequencing detected a de novo heterozygous mutation in the SCN2A gene, encoding the αII-subunit of a sodium channel. The patient findings expand the phenotype spectrum of SCN2A mutations to epileptic encephalopathies with macroscopic brain developmental features.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f988b9c1e37ea6815bf2de45908162Test
https://pubmed.ncbi.nlm.nih.gov/28254201Test

المؤلفون: Michele, Scialpi, Raffaele, Schiavone, Alfredo, D'Andrea, Isabella, Palumbo, Michelle, Magli, Sabrina, Gravante, Giuseppe, Falcone, Claudio, De Filippi, Lucia, Manganaro, Barbara, Palumbo

المصدر: Anticancer research. 35(5)

مصطلحات موضوعية: Male, Adolescent, Child, Preschool, Neoplasms, Multidetector Computed Tomography, Contrast Media, Humans, Infant, Female, Child, Radiation Dosage, Tomography, X-Ray Computed, Neoplasm Staging

الوصف: To evaluate the image quality and the diagnostic efficacy by single-phase whole-body 64-slice multidetector CT (MDCT) for pediatric oncology.Chest-abdomen-pelvis CT examinations with single-phase split-bolus technique were evaluated for T: detection and delineation of primary tumor (assessment of the extent of the lesion to neighboring tissues), N: regional lymph nodes and M: distant metastasis. Quality scores (5-point scale) were assessed by two radiologists on parenchymal and vascular enhancement.Accurate TNM staging in term of detection and delineation of primary tumor, regional lymph nodes and distant metastasis was obtained in all cases. On the image quality and severity artifact, the Kappa value for the interobserver agreement measure obtained from the analysis was 0.754, (p0.001), characterizing a very good agreement between observers.Single-pass total body CT split-bolus technique reached the highest overall image quality and an accurate TNM staging in pediatric patients with cancer.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::9bc1a18e0d96ae2c45dae26e9557f934Test
https://pubmed.ncbi.nlm.nih.gov/26026133Test

المؤلفون: Valerio, Ramieri, Gianmarco, Saponaro, Jacopo, Lenzi, Federico, Caporlingua, Antonella, Polimeni, Alessandro, Silvestri, Antonio, Pizzuti, Mario, Roggini, Luigi, Tarani, Paola, Papoff, Antonella, Giancotti, Marco, Castori, Lucia, Manganaro, Piero, Cascone, Cascone, Piero

مصطلحات موضوعية: Male, Settore MED/29 - CHIRURGIA MAXILLOFACCIALE, craniostenosis, piezosurgery, Cranial surgery, Dentistry, plagiocephaly, Craniosynostosis, Craniofacial Abnormalities, craniofacial malformation, medicine, Humans, Craniofacial, Piezosurgery, cranioplasty, trigonocephaly, scaphocepaly, business.industry, Infant, Soft tissue, General Medicine, medicine.disease, Osteotomy, Treatment Outcome, Otorhinolaryngology, Female, Surgery, business, Bone cutting

الوصف: Piezosurgery is an alternative surgical technique, now widely tested, that uses ultrasounds for bone cutting. This device uses ultrasounds to section hard tissues without harming surrounding soft tissues. The authors analyzed their experience in craniomaxillofacial procedures with piezosurgery. A comparison between operation timing and complication rates between piezosurgery and traditional cutting instruments has been performed. A total of 27 patients were examined (15 females and 12 males; average age, of 5.5 months) affected by craniosynostosis. The aim of this study was to analyze the advantages and disadvantages of piezosurgery in pediatric craniofacial procedures. Piezoelectric device in this study has shown being a valid instrument for bone cutting in accurate procedures, because it allows performing a more precise and safer cutting, without the risk of harming surrounding tissues.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755777521e232c21415b1ea2cfefbc76Test
http://hdl.handle.net/11573/785007Test

المؤلفون: Andrea Lenzi, Francesco Lombardo, Andrea M. Isidori, A. Lemma, Carlotta Pozza, Elisa Giannetta, Giorgio Franco, Lucia Manganaro, Riccardo Pofi, Daniele Gianfrilli, Vito Cantisani, Federica Barbagallo, Martino G

مصطلحات موضوعية: Adult, Male, Incidental Findings, medicine.medical_specialty, business.industry, media_common.quotation_subject, Sulfur Hexafluoride, Contrast Media, ORGAN-SPARING SURGERY, LEYDIG-CELL TUMOR, FOLLOW-UP, ULTRASOUND, TESTIS, SONOGRAPHY, ELASTOGRAPHY, EXPERIENCE, FEATURES, THERAPY, Diagnosis, Differential, Text mining, Testicular Neoplasms, medicine, Humans, Contrast (vision), Radiology, Nuclear Medicine and imaging, Prospective Studies, Radiology, Differential diagnosis, Ultrasonography, business, Prospective cohort study, Phospholipids, media_common

الوصف: To evaluate the diagnostic accuracy of unenhanced and quantitative contrast-enhanced ultrasonography (US) in the differential diagnosis of small nonpalpable testicular lesions.The local review board approved the protocol, and all patients provided written informed consent. One hundred fifteen patients (median age, 34 years; age range, 14-61 years) with nonpalpable testicular lesions were consecutively enrolled between 2006 and 2012 and underwent unenhanced scrotal US, contrast-enhanced US, surgical enucleation, and at least 18 months of follow-up. Clinical and histologic features were recorded, and qualitative and quantitative analysis of contrast-enhanced US time-intensity curves were performed. Logistic regression analysis was performed to explore features of malignancy. Receiver operating characteristic ( ROC receiver operating characteristic ) curves were developed for cumulative unenhanced and contrast-enhanced US scores.All lesions were 1.5 cm or smaller. Forty-four of the 115 patients (38%) had malignant tumors, 42 had benign tumors (37%), and 29 (25%) had nonneoplastic lesions. The features at unenhanced US that enabled the best differentiation of tumors versus nonneoplastic lesions and benign versus malignant tumors were parenchymal microlithiasis (26 of 86 patients with tumors vs five of 29 patients with nonneoplastic lesions [P = .178]; four of 42 patients with benign lesions vs 22 of 44 patients with malignant tumors [P.001]), irregular margins (26 of 86 patients with tumors vs three of 29 patients with nonneoplastic lesions [P.001]; eight of 42 patients with benign lesions vs 18 of 44 patients with malignant tumors [P.001]), and internal vascularization (70 of 86 patients with tumors vs seven of 29 patients with nonneoplastic lesions [P.001]; 28 of 42 patients with benign lesions vs 42 of 44 patients with malignant tumors [P.001]). For contrast-enhanced US, the rapidity of wash-in (34 of 44 patients vs 15 of 42 patients, P.001) and washout (33 of 44 patients vs five of 42 patients, P.001) were the parameters that best differentiated malignant from benign tumors, with a typical prolonged washout observed in Leydig cell tumors (12 of 21 patients, P.001 when compared with seminomas). Overall, the combination of unenhanced and contrast-enhanced US achieved a high accuracy in the diagnosis of small testicular malignancies (area under the ROC receiver operating characteristic curve performance: 0.927; 95% confidence interval: 0.872, 0.981).Benign testicular tumors are frequent incidental findings. Quantitative scrotal contrast-enhanced US is a noninvasive diagnostic tool that could improve the differential diagnosis and individualized management of small testicular lesions.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b79c138b78d8ef1943bf1100597630Test
http://hdl.handle.net/11573/661763Test