المؤلفون: Johnson, Kara L, Qi, Zhijie, Yan, Zhangming, Wen, Xingzhao, Nguyen, Tri C, Zaleta-Rivera, Kathia, Chen, Chien-Ju, Fan, Xiaochen, Sriram, Kiran, Wan, Xueyi, Chen, Zhen Bouman, Zhong, Sheng

المصدر: Molecular Cell. 81(19)

مصطلحات موضوعية: Biological Sciences, Bioinformatics and Computational Biology, Genetics, Human Genome, 2.1 Biological and endogenous factors, Aetiology, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Computational Biology, Databases, Genetic, Female, Gene Expression Profiling, Genes, Lethal, HEK293 Cells, Human Umbilical Vein Endothelial Cells, Humans, Jurkat Cells, Karyopherins, Kidney, Male, Nuclear Matrix-Associated Proteins, Poly (ADP-Ribose) Polymerase-1, Protein Interaction Mapping, Protein Interaction Maps, Proteins, RNA-Binding Proteins, RNA-Seq, Receptors, Cytoplasmic and Nuclear, Software, T-Lymphocytes, Transcription Factors, Transcriptome, beta Karyopherins, Co-immunoprecipitation, Network, PARP1, PROPER-seq, Protein structure, Protein-protein interaction, Proximity ligation assay, SMART-display, Sequencing, Synthetic lethal, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/15c1z1rbTest

المؤلفون: Walker, Janek S, Hing, Zachary A, Harrington, Bonnie, Baumhardt, Jordan, Ozer, Hatice Gulcin, Lehman, Amy, Giacopelli, Brian, Beaver, Larry, Williams, Katie, Skinner, Jordan N, Cempre, Casey B, Sun, Qingxiang, Shacham, Sharon, Stromberg, Benjamin R, Summers, Matthew K, Abruzzo, Lynne V, Rassenti, Laura, Kipps, Thomas J, Parikh, Sameer, Kay, Neil E, Rogers, Kerry A, Woyach, Jennifer A, Coppola, Vincenzo, Chook, Yuh Min, Oakes, Christopher, Byrd, John C, Lapalombella, Rosa

المصدر: Journal of Hematology & Oncology. 14(1)

مصطلحات موضوعية: Rare Diseases, Lymphoma, Cancer, Genetics, Hematology, 2.1 Biological and endogenous factors, Aetiology, Animals, Epigenesis, Genetic, Female, Gene Expression Regulation, Leukemic, Humans, Karyopherins, Leukemia, Lymphocytic, Chronic, B-Cell, Male, Mice, Inbred C57BL, Models, Molecular, Mutation, Receptors, Cytoplasmic and Nuclear, Retrospective Studies, Transcriptome, XPO1, Chronic lymphocytic leukemia, Mouse model, Selinexor, Sines, Expression profiling, Mutation analysis, Cardiorespiratory Medicine and Haematology, Oncology and Carcinogenesis

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9jv0q230Test

المؤلفون: Bick, Alexander G, Weinstock, Joshua S, Nandakumar, Satish K, Fulco, Charles P, Bao, Erik L, Zekavat, Seyedeh M, Szeto, Mindy D, Liao, Xiaotian, Leventhal, Matthew J, Nasser, Joseph, Chang, Kyle, Laurie, Cecelia, Burugula, Bala Bharathi, Gibson, Christopher J, Niroula, Abhishek, Lin, Amy E, Taub, Margaret A, Aguet, Francois, Ardlie, Kristin, Mitchell, Braxton D, Barnes, Kathleen C, Moscati, Arden, Fornage, Myriam, Redline, Susan, Psaty, Bruce M, Silverman, Edwin K, Weiss, Scott T, Palmer, Nicholette D, Vasan, Ramachandran S, Burchard, Esteban G, Kardia, Sharon LR, He, Jiang, Kaplan, Robert C, Smith, Nicholas L, Arnett, Donna K, Schwartz, David A, Correa, Adolfo, de Andrade, Mariza, Guo, Xiuqing, Konkle, Barbara A, Custer, Brian, Peralta, Juan M, Gui, Hongsheng, Meyers, Deborah A, McGarvey, Stephen T, Chen, Ida Yii-Der, Shoemaker, M Benjamin, Peyser, Patricia A, Broome, Jai G, Gogarten, Stephanie M, Wang, Fei Fei, Wong, Quenna, Montasser, May E, Daya, Michelle, Kenny, Eimear E, North, Kari E, Launer, Lenore J, Cade, Brian E, Bis, Joshua C, Cho, Michael H, Lasky-Su, Jessica, Bowden, Donald W, Cupples, L Adrienne, Mak, Angel CY, Becker, Lewis C, Smith, Jennifer A, Kelly, Tanika N, Aslibekyan, Stella, Heckbert, Susan R, Tiwari, Hemant K, Yang, Ivana V, Heit, John A, Lubitz, Steven A, Johnsen, Jill M, Curran, Joanne E, Wenzel, Sally E, Weeks, Daniel E, Rao, Dabeeru C, Darbar, Dawood, Moon, Jee-Young, Tracy, Russell P, Buth, Erin J, Rafaels, Nicholas, Loos, Ruth JF, Durda, Peter, Liu, Yongmei, Hou, Lifang, Lee, Jiwon, Kachroo, Priyadarshini, Freedman, Barry I, Levy, Daniel, Bielak, Lawrence F, Hixson, James E, Floyd, James S, Whitsel, Eric A, Ellinor, Patrick T, Irvin, Marguerite R, Fingerlin, Tasha E, Raffield, Laura M, Armasu, Sebastian M

المصدر: Nature. 586(7831)

مصطلحات موضوعية: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Biotechnology, Regenerative Medicine, Stem Cell Research, Human Genome, Underpinning research, Aetiology, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Cardiovascular, Generic health relevance, Inflammatory and immune system, Good Health and Well Being, Adult, Africa, Aged, Aged, 80 and over, Black People, Cell Self Renewal, Clonal Hematopoiesis, DNA-Binding Proteins, Dioxygenases, Female, Genetic Predisposition to Disease, Genome, Human, Germ-Line Mutation, Hematopoietic Stem Cells, Humans, Intracellular Signaling Peptides and Proteins, Male, Middle Aged, National Heart, Lung, and Blood Institute (U.S.), Phenotype, Precision Medicine, Proto-Oncogene Proteins, Tripartite Motif Proteins, United States, Whole Genome Sequencing, alpha Karyopherins, NHLBI Trans-Omics for Precision Medicine Consortium, General Science & Technology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7w16b34nTest

المؤلفون: Hobbs, Brian D, Putman, Rachel K, Araki, Tetsuro, Nishino, Mizuki, Gudmundsson, Gunnar, Gudnason, Vilmundur, Eiriksdottir, Gudny, Zilhao Nogueira, Nuno Rodrigues, Dupuis, Josée, Xu, Hanfei, O'Connor, George T, Manichaikul, Ani, Nguyen, Jennifer, Podolanczuk, Anna J, Madahar, Purnema, Rotter, Jerome I, Lederer, David J, Barr, R Graham, Rich, Stephen S, Ampleford, Elizabeth J, Ortega, Victor E, Peters, Stephen P, O'Neal, Wanda K, Newell, John D, Bleecker, Eugene R, Meyers, Deborah A, Allen, Richard J, Oldham, Justin M, Ma, Shwu-Fan, Noth, Imre, Jenkins, R Gisli, Maher, Toby M, Hubbard, Richard B, Wain, Louise V, Fingerlin, Tasha E, Schwartz, David A, Washko, George R, Rosas, Ivan O, Silverman, Edwin K, Hatabu, Hiroto, Cho, Michael H, Hunninghake, Gary M

المصدر: American journal of respiratory and critical care medicine. 200(11)

مصطلحات موضوعية: Humans, Lung Diseases, Interstitial, Genetic Predisposition to Disease, beta Karyopherins, TATA Box Binding Protein-Like Proteins, Case-Control Studies, Polymorphism, Single Nucleotide, Aged, Middle Aged, Female, Male, Promoter Regions, Genetic, Idiopathic Pulmonary Fibrosis, Genome-Wide Association Study, Mucin-5B, Genetic Loci, SNP, genetics, genome-wide association study, idiopathic pulmonary fibrosis, interstitial lung abnormalities, Genetics, Lung, Rare Diseases, Chronic Obstructive Pulmonary Disease, Clinical Research, Prevention, Human Genome, Autoimmune Disease, Aging, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Medical and Health Sciences, Respiratory System

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6mb5z7wwTest

المؤلفون: Acosta-Herrera, Marialbert, Kerick, Martin, González-Serna, David, Consortium, Myositis Genetics, Consortium, Scleroderma Genetics, Wijmenga, Cisca, Franke, Andre, Gregersen, Peter K, Padyukov, Leonid, Worthington, Jane, Vyse, Timothy James, Alarcón-Riquelme, Marta Eugenia, Mayes, Maureen D, Martin, Javier

المصدر: Annals of the Rheumatic Diseases. 78(3)

مصطلحات موضوعية: Human Genome, Autoimmune Disease, Arthritis, Genetics, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Adult, Arthritis, Rheumatoid, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Lim Kinases, Lupus Erythematosus, Systemic, Male, Membrane Proteins, Myositis, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Repressor Proteins, Rheumatic Diseases, Scleroderma, Systemic, White People, alpha Karyopherins, Myositis Genetics Consortium, Scleroderma Genetics Consortium, autoimmune diseases, autoimmunity, gene polymorphism, Clinical Sciences, Immunology, Public Health and Health Services, Arthritis & Rheumatology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4v15h5swTest

المؤلفون: Vogl, Dan T, Dingli, David, Cornell, Robert Frank, Huff, Carol Ann, Jagannath, Sundar, Bhutani, Divaya, Zonder, Jeffrey, Baz, Rachid, Nooka, Ajay, Richter, Joshua, Cole, Craig, Vij, Ravi, Jakubowiak, Andrzej, Abonour, Rafat, Schiller, Gary, Parker, Terri L, Costa, Luciano J, Kaminetzky, David, Hoffman, James E, Yee, Andrew J, Chari, Ajai, Siegel, David, Fonseca, Rafael, Van Wier, Scott, Ahmann, Gregory, Lopez, Ilsel, Kauffman, Michael, Shacham, Sharon, Saint-Martin, Jean-Richard, Picklesimer, Carla D, Choe-Juliak, Cassandra, Stewart, A Keith

المصدر: Journal of Clinical Oncology. 36(9)

مصطلحات موضوعية: Hematology, Cancer, Clinical Research, Clinical Trials and Supportive Activities, Rare Diseases, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Active Transport, Cell Nucleus, Administration, Oral, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Dexamethasone, Dose-Response Relationship, Drug, Female, Humans, Hydrazines, Karyopherins, Male, Middle Aged, Multiple Myeloma, Progression-Free Survival, Receptors, Cytoplasmic and Nuclear, Triazoles, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/198927fqTest

المؤلفون: Garg, Manoj, Kanojia, Deepika, Mayakonda, Anand, Said, Jonathan W, Doan, Ngan B, Chien, Wenwen, Ganesan, Trivadi S, Chuang, Linda Shyue Huey, Venkatachalam, Nachiyappan, Baloglu, Erkan, Shacham, Sharon, Kauffman, Michael, Koeffler, H Phillip

المصدر: Oncotarget. 5

مصطلحات موضوعية: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biotechnology, Cancer, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Aetiology, Development of treatments and therapeutic interventions, Animals, Antineoplastic Agents, Apoptosis, Aurora Kinase A, Aurora Kinase B, Cell Cycle Checkpoints, Cell Line, Tumor, Cell Proliferation, Dose-Response Relationship, Drug, Gene Expression Regulation, Neoplastic, Humans, Hydrazines, Insulin-Like Growth Factor Binding Protein 5, Karyopherins, Liposarcoma, Male, Mice, Proto-Oncogene Proteins c-akt, RNA Interference, Receptor, IGF Type 1, Receptors, Cytoplasmic and Nuclear, Receptors, Somatomedin, Signal Transduction, Time Factors, Transfection, Triazoles, Tumor Burden, Xenograft Model Antitumor Assays, selinexor, IGFBP5, xenograft, cell cycle, Oncology and carcinogenesis

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/80d7d67sTest

المؤلفون: Kottyan, Leah C, Zoller, Erin E, Bene, Jessica, Lu, Xiaoming, Kelly, Jennifer A, Rupert, Andrew M, Lessard, Christopher J, Vaughn, Samuel E, Marion, Miranda, Weirauch, Matthew T, Namjou, Bahram, Adler, Adam, Rasmussen, Astrid, Glenn, Stuart, Montgomery, Courtney G, Hirschfield, Gideon M, Xie, Gang, Coltescu, Catalina, Amos, Chris, Li, He, Ice, John A, Nath, Swapan K, Mariette, Xavier, Bowman, Simon, Rischmueller, Maureen, Lester, Sue, Brun, Johan G, Gøransson, Lasse G, Harboe, Erna, Omdal, Roald, Cunninghame-Graham, Deborah S, Vyse, Tim, Miceli-Richard, Corinne, Brennan, Michael T, Lessard, James A, Wahren-Herlenius, Marie, Kvarnström, Marika, Illei, Gabor G, Witte, Torsten, Jonsson, Roland, Eriksson, Per, Nordmark, Gunnel, Ng, Wan-Fai, Anaya, Juan-Manuel, Rhodus, Nelson L, Segal, Barbara M, Merrill, Joan T, James, Judith A, Guthridge, Joel M, Scofield, R Hal, Alarcon-Riquelme, Marta, Bae, Sang-Cheol, Boackle, Susan A, Criswell, Lindsey A, Gilkeson, Gary, Kamen, Diane L, Jacob, Chaim O, Kimberly, Robert, Brown, Elizabeth, Edberg, Jeffrey, Alarcón, Graciela S, Reveille, John D, Vilá, Luis M, Petri, Michelle, Ramsey-Goldman, Rosalind, Freedman, Barry I, Niewold, Timothy, Stevens, Anne M, Tsao, Betty P, Ying, Jun, Mayes, Maureen D, Gorlova, Olga Y, Wakeland, Ward, Radstake, Timothy, Martin, Ezequiel, Martin, Javier, Siminovitch, Katherine, Sivils, Kathy L Moser, Gaffney, Patrick M, Langefeld, Carl D, Harley, John B, Kaufman, Kenneth M

المصدر: Human Molecular Genetics. 24(2)

مصطلحات موضوعية: Biological Sciences, Genetics, Autoimmune Disease, Biotechnology, Lupus, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Autoimmune Diseases, Bayes Theorem, Case-Control Studies, Cohort Studies, DNA-Binding Proteins, Haplotypes, Humans, Interferon Regulatory Factors, Lupus Erythematosus, Systemic, Male, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, beta Karyopherins, UK Primary Sjögren's Syndrome Registry, Medical and Health Sciences, Genetics & Heredity

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5w39878cTest

المؤلفون: Sun, H, Hattori, N, Chien, W, Sun, Q, Sudo, M, E-Ling, GL, Ding, L, Lim, SL, Shacham, S, Kauffman, M, Nakamaki, T, Koeffler, HP

المصدر: British Journal of Cancer. 111(2)

مصطلحات موضوعية: Lung Cancer, Genetics, Cancer, Lung, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Animals, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Carcinoma, Non-Small-Cell Lung, Cell Growth Processes, Cell Line, Tumor, Cisplatin, G1 Phase, Genes, p53, Humans, Hydrazines, Karyopherins, Lung Neoplasms, Male, Mice, Mice, Inbred NOD, Mice, SCID, Mutation, Receptors, Cytoplasmic and Nuclear, Triazoles, Xenograft Model Antitumor Assays, CRM1, SINE, NSCLC, p53, p73, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/41c728pvTest

المؤلفون: Wettersten, Hiromi I, Landesman, Yosef, Friedlander, Sharon, Shacham, Sharon, Kauffman, Michael, Weiss, Robert H

المصدر: PloS one. 9(12)

مصطلحات موضوعية: Cell Line, Tumor, Cell Nucleus, Epithelial Cells, Animals, Humans, Mice, Nude, Carcinoma, Renal Cell, Kidney Neoplasms, Hydrazines, Triazoles, Karyopherins, Receptors, Cytoplasmic and Nuclear, RNA, Small Interfering, Administration, Oral, Drug Approval, Xenograft Model Antitumor Assays, Apoptosis, Cell Proliferation, Cell Survival, Active Transport, Cell Nucleus, Drug Resistance, Neoplasm, United States Food and Drug Administration, United States, Male, Cyclin-Dependent Kinase Inhibitor p21, Cell Cycle Checkpoints, Cell Line, Tumor, Mice, Nude, Carcinoma, Renal Cell, Receptors, Cytoplasmic and Nuclear, RNA, Small Interfering, Administration, Oral, Active Transport, Drug Resistance, Neoplasm, General Science & Technology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/1cn9r94fTest