Interictal psychiatric comorbidities of drug-resistant focal epilepsy: Prevalence and influence of the localization of the epilepsy
| العنوان: | Interictal psychiatric comorbidities of drug-resistant focal epilepsy: Prevalence and influence of the localization of the epilepsy |
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| المؤلفون: | Louis Maillard, Jean-Pierre Vignal, Claire Jansen, Louise Tyvaert, Léa Francomme, Raymund Schwan, Caroline Jacquot, Coraline Hingray |
| المساهمون: | Centre Psychothérapique de Nancy [Laxou] (CPN), Faculté de Médecine [Nancy], Université de Lorraine (UL), Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie (NCPS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Civil de Strasbourg, Centre de Recherche en Automatique de Nancy (CRAN), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Service de neurologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy) |
| المصدر: | Epilepsy & Behavior Epilepsy & Behavior, [San Diego CA]: Elsevier B.V., 2019, 94, pp.288-296. ⟨10.1016/j.yebeh.2018.06.046⟩ |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Drug Resistant Epilepsy, Adolescent, Population, Mood disorder, Generalized Anxiety Disorder 7, Comorbidity, 03 medical and health sciences, Behavioral Neuroscience, Epilepsy, Young Adult, 0302 clinical medicine, Alexithymia, mental disorders, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Psychiatry, education, Anatomopathological, education.field_of_study, Drug-resistant focal epilepsy, business.industry, Mood Disorders, Middle Aged, Interictal disorder, medicine.disease, Anxiety Disorders, 3. Good health, Neurology, Mood disorders, Anxiety disorder, Anxiety, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), Epilepsies, Partial, medicine.symptom, business, 030217 neurology & neurosurgery |
| الوصف: | International audience; Psychiatric comorbidities are 2 to 3 times more frequent in patients with epilepsy than in the general population. This study aimed to prospectively assess the following: (i) the prevalence of specific and nonspecific interictal psychiatric comorbidities in a population of patients with drug-resistant focal epilepsy and (ii) the influence of epilepsy lateralization and localization on these psychiatric comorbidities.In this prospective monocentric study, we collected demographic data, characteristics of the epilepsy, interictal psychiatric comorbidities, mood, anxiety, and alexithymia dimensions. We used criteria from Diagnostic and Statistical Manual of Mental Disorders IV ( DSM IV) (Mini International Mental Interview (MINI)), diagnosis criteria for specific comorbidities, and validated mood and anxiety scales (general and specific for epilepsy).Among the 87 enrolled patients (39 males, 48 females), 52.9% had at least one psychiatric comorbidity. The most common comorbidity was anxiety disorder (28.7% according to the MINI, and 38.4% screening by the Generalized Anxiety Disorder 7 (GAD 7)). Mood disorders were the second most frequent psychiatric comorbidity: 21.8% of our patients had interictal dysphoric disorders (IDDs), 16.1% presented major depressive disorders according to the MINI, and 17.2% screening by the Neurological Disorders Depression Inventory for Epilepsy (NDDIE).Patients with temporal lobe epilepsy had a higher prevalence of psychiatric comorbidities than patients with extratemporal lobe epilepsy (p = 0.002), which is probably related to a higher rate of anxiety disorders in this subgroup (p = 0.012). Prevalence of psychiatric disorders prior to epilepsy in patients was higher in right- than in left-sided epilepsy (p = 0.042). No difference was found according to limbic involvement at seizure onset.Overall, this article highlighted a very high proportion of anxiety disorders in these patients with drug-resistant focal epilepsy and the necessity to systematically detect them and thus lead to a specific treatment. |
| اللغة: | English |
| تدمد: | 1525-5050 1525-5069 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae68a0ae1d02aeb95152ac7242645fd1Test https://hal.archives-ouvertes.fr/hal-01947262/file/S1525505018303603.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ae68a0ae1d02aeb95152ac7242645fd1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15255050 15255069 |
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