المؤلفون: Xiao-Yan Pan, Wen-Yue Liu, Pei-Wu Zhu, Gang Li, Liang-Jie Tang, Feng Gao, Ou-Yang Huang, Hai-Yang Yuan, Giovanni Targher, Christopher D. Byrne, Xiao-Dong Wang, Ming-Hua Zheng

المصدر: Hepatology International. 16:1085-1093

مصطلحات موضوعية: Male, Sarcopenia, Hepatology, Patatin-like phospholipase domain-containing 3, Membrane Proteins, Skeletal, Single Nucleotide, Lipase, Polymorphism, Single Nucleotide, Skeletal muscle mass, Liver, Non-alcoholic Fatty Liver Disease, Phospholipases, Creatinine, Muscle, Humans, Genetic Predisposition to Disease, Polymorphism, Muscle, Skeletal

الوصف: Although low skeletal muscle mass is associated with non-alcoholic fatty liver disease (NAFLD), it is currently uncertain whether there are associations between weight-adjusted appendicular skeletal muscle (ASM%), severity of histological features of NAFLD, and the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism. Our aim was to test for a possible influence of the PNPLA3 rs738409 variant on the association between ASM% and severity of NAFLD histological features.We enrolled 401 Chinese male with biopsy-proven NAFLD. Using a bioelectrical-impedance body composition analyzer (BIA, Inbody 720, Japan Inc., Tokyo), we calculated the ASM% as the percentage of total appendicular skeletal muscle mass (ASM, kg)/total body mass (kg) × 100.Compared to those with high ASM%, patients with low ASM% (≤ 30.6, i.e., the median value of distribution of the whole sample) had a greater severity of individual histological features of NAFLD. These patients also had a higher risk of severe steatosis and non-alcoholic steatohepatitis (NASH) (adjusted-odds ratio [OR] 2.34, 95% CI 1.39-3.93, and adjusted-OR 2.22, 95% CI 1.30-3.77) even after adjusting for age, body mass index, diabetes, and serum creatinine levels. Carriage of the G allele of PNPLA3 rs738409 plus low ASM% was associated with a higher risk of severe steatosis and presence of liver fibrosis (OR 3.02, 95% CI 1.46-6.26, p = 0.003 and OR 2.18, 95% CI 1.03-4.60, p = 0.041 respectively), and there was a non-significant but borderline increased risk of NASH (OR 2.00, 95% CI 0.98-4.06, p = 0.056).Low ASM% and the presence of a G allele within PNPLA3 rs738409 is associated with more severe histological features of NAFLD.

وصف الملف: text; image

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d17107bc34dc219e4b9f0eac8b44b2Test
https://doi.org/10.1007/s12072-022-10384-xTest

المؤلفون: Zhong-Wei Chen, Xiao-Dong Wang, Yang-Zong Chen, You-Fan Zhao, Ming-Hua Zheng, Liang-Jie Tang, Giovanni Targher, Xiangwu Zheng, Ou-Yang Huang, Kun Tang, Christopher D. Byrne, Gang Li

المصدر: International Journal of Medical Sciences

مصطلحات موضوعية: Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Metabolic dysfunction-associated fatty liver disease, China, Biopsy, Liver fibrosis, Pilot Projects, Logistic regression, Fibrosis, Region of interest, Fluorodeoxyglucose F18, Non-alcoholic Fatty Liver Disease, Predictive Value of Tests, Positron Emission Tomography Computed Tomography, medicine, Humans, Radiometry, Radiomics, Receiver operating characteristic, medicine.diagnostic_test, business.industry, Fatty liver, 18F-FDG PET/CT, General Medicine, Middle Aged, medicine.disease, Linear discriminant analysis, Prognosis, Confidence interval, Positron emission tomography, Disease Progression, Female, Radiology, business, Research Paper

الوصف: Rationale: since non-invasive tests for prediction of liver fibrosis have a poor diagnostic performance for detecting low levels of fibrosis, it is important to explore the diagnostic capabilities of other non-invasive tests to diagnose low levels of fibrosis. We aimed to evaluate the performance of radiomics based on 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) in predicting any liver fibrosis in individuals with biopsy-proven metabolic dysfunction-associated fatty liver disease (MAFLD).Methods: a total of 22 adults with biopsy-confirmed MAFLD, who underwent 18F-FDG PET/CT, were enrolled in this study. Sixty radiomics features were extracted from whole liver region of interest in 18F-FDG PET images. Subsequently, the minimum redundancy maximum relevance (mRMR) method was performed and a subset of two features mostly related to the output classes and low redundancy between them were selected according to an event per variable of 5. Logistic regression, Support Vector Machine, Naive Bayes, 5-Nearest Neighbor and linear discriminant analysis models were built based on selected features. The predictive performances were assessed by the receiver operator characteristic (ROC) curve analysis.Results: the mean (SD) age of the subjects was 38.5 (10.4) years and 17 subjects were men. 12 subjects had histological evidence of any liver fibrosis. The coarseness of neighborhood grey-level difference matrix (NGLDM) and long-run emphasis (LRE) of grey-level run length matrix (GLRLM) were selected to predict fibrosis. The logistic regression model performed best with an AUROC of 0.817 [95% confidence intervals, 0.595-0.947] for prediction of liver fibrosis.Conclusion: these preliminary data suggest that 18F-FDG PET radiomics may have clinical utility in assessing early liver fibrosis in MAFLD.

وصف الملف: text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f33860d014e4a87d0ac5ea43162f5caTest
http://europepmc.org/articles/PMC8579290Test

المؤلفون: Huaming Wang, Hua Zheng, Jie Yin, Yiqing Guo

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports

مصطلحات موضوعية: Male, Thyroid nodules, Cell biology, RNA, Untranslated, Adolescent, Molecular biology, Science, Apoptosis, Malignancy, Polymorphism, Single Nucleotide, Article, Papillary thyroid cancer, Cell Line, Tumor, medicine, Humans, Doubling time, Proto-Oncogene Proteins c-cbl, Thyroid Nodule, Allele, Child, Multidisciplinary, business.industry, Thyroid, Nodule (medicine), medicine.disease, MicroRNAs, medicine.anatomical_structure, Hepatocellular carcinoma, Cancer research, Medicine, Female, medicine.symptom, business, Signal Transduction

الوصف: Recent evidence revealed an inhibitory effect of circ-ITCH on the progression of papillary thyroid cancer via affecting the circ-ITCH/miR-22-3p/CBL axis. Rs4911154, an SNP located in circ-ITHC, was previously reported to be significantly associated with an increased risk of hepatocellular carcinoma. Ultrasound testing was used to evaluate the doubling time of thyroid nodules. 202 patients diagnosed with thyroid nodule disorders were divided into three groups according to their genotypes at rs4911154. We found that the A allele was correlated with a shortening doubling time of thyroid nodules. Moreover, the A allele contributed to reduced expression of circ-ITCH/CBL and increased expression of miR-22-3p. Besides, decreased tissue apoptosis was linked to the A allele. Luciferase assays indicated that miR-22-3p could effectively suppress the luciferase activities of CBL and circ-ITCH. Furthermore, manual up-regulation of miR-22-3p effectively suppressed the expression of CBL, while CBL siRNA apparently abolished circ-ITCH induced CBL upregulation, reduced proliferation and increased apoptosis of K1 and TPC-1 cells. A signaling pathway of circ-ITCH/miR-22-3p/CBL axis was established to explain the effect of SNP of circ-ITCH in thyroid tumor malignancy. Compared with the G allele, the A allele in rs4911154 contributed to the malignancy of thyroid nodules with decreased doubling time and down-regulated CBL expression.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919707a2012aa4113f72b873e09e02fbTest
https://doaj.org/article/4a7448a34e11440a871d2dbc058a4798Test

المؤلفون: Juan, Feng, Hai-Long, Tang, Rui-Feng, Yuan, Li, Xu, Yan-Hua, Zheng, Rong, Liang, Qing-Xian, Bai, Tao, Zhang, Lan, Yang, Hong-Tao, Gu, Guang-Xun, Gao

المصدر: Zhongguo shi yan xue ye xue za zhi. 30(4)

مصطلحات موضوعية: Adult, Male, Adolescent, Receptor Protein-Tyrosine Kinases, Middle Aged, Prognosis, Disease-Free Survival, Young Adult, Antineoplastic Combined Chemotherapy Protocols, Humans, Lymphoma, Large-Cell, Anaplastic, Female, Child, Aged, Retrospective Studies

الوصف: To evaluate the clinical characteristics, treatment and prognosis of systemic anaplastic large cell lymphoma(sALCL).The clinical data of 90 cases with sALCL treated in the Department of Hematology of the Affiliated Xijing Hospital of Air Force Medical University from November 2018 to October 2021 were retrospectively analyzed. The clinical features, treatment and prognosis were summarized and the prognostic factors were investigated.There were 58 males and 32 females, with a median age of 32 (12-73) years old. 69 (76.7%) patients had Ann Arbor stage Ⅲ-Ⅳ disease and half of the patients had extranodal infiltration. The median age was 27(12-72) years of the 60 ALKsALCL mainly occurs in males and most patients were in advanced stage. Half of the patients had extranodal involvement. The CR rate after first-line chemotherapy was 568%, and IPI score≥3 was a significant prognostic factor for CR. No achievement of CR after first-line therapy is poorly prognostic for PFS and OS.系统性间变大细胞淋巴瘤患者的临床特点及预后分析.评价系统性间变大细胞淋巴瘤（sALCL）患者的临床特征、治疗及预后.回顾性分析2018年11月至2021年10月空军军医大学西京医院血液内科收治的90例sALCL患者的临床资料，总结其临床特点、治疗及预后，并探讨预后影响因素.90例sALCL患者中男性58例，女性32例，中位年龄32（12－73）岁。69例（76.7%）患者发病时Ann Arbor 分期为Ⅲ－Ⅳ期，半数患者有结外病变。ALKsALCL以男性居多，诊断时多处于进展期，50%患者合并结外病变。一线化疗后CR率为56.8%，IPI≥3分是一线化疗后CR的不良影响因素。一线化疗后未达CR是PFS及OS 的不良预后因素.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::af17685139c8c20d8cb1d5c64df97b2fTest
https://pubmed.ncbi.nlm.nih.gov/35981369Test

المؤلفون: Xin-Xin Wang, Christopher D. Byrne, Giovanni Targher, Gang Li, Hong-Lei Ma, Kenneth I. Zheng, Liang-Jie Tang, Ming-Hua Zheng, Xiao-Yan Pan, Yi Jin, Ou-Yang Huang, Yue Yu, Rafael S Rios

المصدر: British Journal of Nutrition. 127:1613-1620

مصطلحات موضوعية: Male, Liver Cirrhosis, medicine.medical_specialty, Biopsy, Appendicular skeletal muscle mass, Medicine (miscellaneous), 030209 endocrinology & metabolism, Intra-Abdominal Fat, digestive system, Gastroenterology, Presence of fibrosis, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, Internal medicine, medicine, Humans, Sarcopenic obesity, Obesity, Risk factor, Muscle, Skeletal, Non-alcoholic steatohepatitis, Abdominal obesity, Nutrition and Dietetics, medicine.diagnostic_test, business.industry, Fatty liver, nutritional and metabolic diseases, Middle Aged, medicine.disease, digestive system diseases, Visceral fat area, Obesity, Abdominal, Cohort, Female, 030211 gastroenterology & hepatology, medicine.symptom, business, Bioelectrical impedance analysis, Non-alcoholic fatty liver disease

الوصف: Sarcopenic obesity is regarded as a risk factor for the progression and development of non-alcoholic fatty liver disease (NAFLD). Since male sex is a risk factor for NAFLD and skeletal muscle mass markedly varies between the sexes, we examined whether sex influences the association between appendicular skeletal muscle mass to visceral fat area ratio (SVR), that is, an index of skeletal muscle mass combined with abdominal obesity, and the histological severity of NAFLD. The SVR was measured by bioelectrical impedance in a cohort of 613 (M/F = 443/170) Chinese middle-aged individuals with biopsy-proven NAFLD. Multivariable logistic regression and subgroup analyses were used to test the association between SVR and the severity of NAFLD (i.e. non-alcoholic steatohepatitis (NASH) or NASH with the presence of any stage of liver fibrosis). NASH was identified by a NAFLD activity score ≥5, with a minimum score of 1 for each of its categories. The presence of fibrosis was classified as having a histological stage ≥1. The SVR was inversely associated with NASH in men (adjusted OR 0·62; 95 % CI 0·42, 0·92, P = 0·017 for NASH, adjusted OR 0·65; 95 % CI 0·43, 0·99, P = 0·043 for NASH with the presence of fibrosis), but not in women (1·47 (95 % CI 0·76, 2·83), P = 0·25 for NASH, and 1·45 (95 % CI 0·74, 2·83), P = 0·28 for NASH with the presence of fibrosis). There was a significant interaction for sex and SVR (Pinteraction = 0·017 for NASH and Pinteraction = 0·033 for NASH with the presence of fibrosis). Our findings show that lower skeletal muscle mass combined with abdominal obesity is strongly associated with the presence of NASH only in men.

وصف الملف: text; image

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4939a803f8cd38f8bfb1d516c31476f8Test
https://doi.org/10.1017/s0007114521002415Test

المؤلفون: Yan-Song Yang, Feng Feng, Hai-Peng Gong, Yue-Tao Wang, Yong-Juan Qiu, Ya-Qiong Ge, Gui-Hua Zheng, Yi-Fei Zhang

المصدر: Cancer Imaging, Vol 21, Iss 1, Pp 1-10 (2021)
Cancer Imaging

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Colorectal cancer, Perineural invasion, R895-920, Logistic regression, Nerve Sheath Neoplasms, Nomogram, 03 medical and health sciences, Medical physics. Medical radiology. Nuclear medicine, 0302 clinical medicine, Magnetic resonance imaging, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Radical surgery, Rectal cancer, Radiometry, RC254-282, Aged, Retrospective Studies, Aged, 80 and over, Radiomics, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Rectal Neoplasms, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Confidence interval, Nomograms, 030104 developmental biology, Logistic Models, Oncology, 030220 oncology & carcinogenesis, Female, Radiology, business, Research Article

الوصف: Background To establish and validate a high-resolution magnetic resonance imaging (HRMRI)-based radiomic nomogram for prediction of preoperative perineural invasion (PNI) of rectal cancer (RC). Methods Our retrospective study included 140 subjects with RC (99 in the training cohort and 41 in the validation cohort) who underwent a preoperative HRMRI scan between December 2016 and December 2019. All subjects underwent radical surgery, and then PNI status was evaluated by a qualified pathologist. A total of 396 radiomic features were extracted from oblique axial T2 weighted images, and optimal features were selected to construct a radiomic signature. A combined nomogram was established by incorporating the radiomic signature, HRMRI findings, and clinical risk factors selected by using multivariable logistic regression. Results The predictive nomogram of PNI included a radiomic signature, and MRI-reported tumor stage (mT-stage). Clinical risk factors failed to increase the predictive value. Favorable discrimination was achieved between PNI-positive and PNI-negative groups using the radiomic nomogram. The area under the curve (AUC) was 0.81 (95% confidence interval [CI], 0.71–0.91) in the training cohort and 0.75 (95% CI, 0.58–0.92) in the validation cohort. Moreover, our result highlighted that the radiomic nomogram was clinically beneficial, as evidenced by a decision curve analysis. Conclusions HRMRI-based radiomic nomogram could be helpful in the prediction of preoperative PNI in RC patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d05c7d878ca605af394e65f8027cbbTest
https://doaj.org/article/3307b14324a74c78bc37463d7d8fb16cTest

المؤلفون: Miao-Miao, Hong, En-Cong, Zhao, Li-Min, Chen, Feng, Wang, Wan-Qing, Guo, Xue-Hua, Zheng, Lan, Lin, Chang-Zheng, Li, Wei-Guo, Dong

المصدر: Zhen ci yan jiu = Acupuncture research. 47(6)

مصطلحات موضوعية: Male, Mice, Electroacupuncture, Phagocytosis, Memory, Complement C1q, Animals, Microglia, RNA, Messenger, Hippocampus

الوصف: To observe the effect of electroacupuncture (EA) on the expression of Iba-1, complement C1q and CD68 in hippocampus of SAMP8 mice, so as to explore its mechanisms underlying improvement of Alzheimer's disease (AD).Twenty-four male SAMP8 mice were randomly and equally divided into model and EA groups, and 12 SAMR1 mice were used as the control group. EA (2 Hz, 1.5-2.0 mA) was applied to "Baihui" (GV20), "Dazhui"(GV14) and "Shen-shu"(BL23) for 20 min once daily in the EA group, each course of treatment was 8 days, with an interval of 2 days between two courses, and the mice were treated for 3 courses. Morris water maze test was performed to assess the learning-memory ability of mice. The positive expression levels of Iba-1 and CD68 proteins in the hippocampus CA1 region were detected by immunohistochemistry. The mRNA and protein expression levels of Iba-1,C1q and CD68 in the hippocampus were detected by real-time PCR and Western blot, separately.Compared with the control group, the average escape latency of Morris water maze test was prolonged in the model group (EA can improve the learning and memory ability of SAMP8 mice, which may be associated with its effect in inhibiting of complement C1q-dependent microglial phagocytosis in the hippocampus.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::6f872a3282b978d17dd1cd177014e0aeTest
https://pubmed.ncbi.nlm.nih.gov/35764513Test

المؤلفون: Sui-Dan Chen, Huai Zhang, Rafael S. Rios, Yang-Yang Li, Pei-Wu Zhu, Yi Jin, Hong-Lei Ma, Liang-Jie Tang, Gang Li, Ou-Yang Huang, Kenneth I. Zheng, Christopher D. Byrne, Giovanni Targher, Ming-Hua Zheng

مصطلحات موضوعية: Adult, Inflammation, Male, Liver Cirrhosis, Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), MAFLD, Liver biopsy, Zinc, Serum zinc, Non-alcoholic Fatty Liver Disease, Humans, Female, Cardiology and Cardiovascular Medicine, Hepatic necro-inflammation

الوصف: Background and Aims Zinc is an essential trace element that plays an important role in maintaining health, and affecting gene expression, signal transduction and regulation of apoptosis. It is uncertain whether serum zinc levels are altered in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). We aimed to investigate the association between serum zinc levels and the severity of hepatic necro-inflammation (HN) in patients with MAFLD. Methods and Results Liver disease severity was graded histologically using the NAFLD activity score. HN was defined as the sum of ballooning and lobular inflammation. We used a smooth function regression model to analyze the relationship between serum zinc levels and HN. A total of 561 (76.5% men) patients with biopsy-confirmed MAFLD were enrolled. They had a mean age of 41.3 years, and a mean serum zinc level of 17.0 ± 4.1 μmol/L. Compared to those with mild hepatic necro-inflammation (MHN, grades 0-2; n=286), patients with severe hepatic necro-inflammation (SHN, grades 3-5; n=275) had lower serum zinc concentrations (16.3±4.2 vs. 17.6±4.0 μmol/L; p24 μmol/L were positively associated with SHN (adjusted-odds ratio 1.42, 95%CI: 1.03-1.97; p=0.035). Conclusions There is a J-shaped relationship between serum zinc levels and the severity of hepatic necro-inflammation in patients with biopsy-proven MAFLD.

وصف الملف: text; image

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5de48c642d39e767719bd08a911d5eTest
https://eprints.soton.ac.uk/454758Test/

المؤلفون: Xueqing Tang, Hua Zheng, Haiyun Wang, Peng Xia, Ying Wang, Xue Zhao, Zijuan Zhou, Ling Qiu, Xuemei Li, Limeng Chen

المصدر: Renal failure. 44(1)

مصطلحات موضوعية: Adult, Chronic Kidney Disease-Mineral and Bone Disorder, Cohort Studies, Male, China, Nephrology, Humans, General Medicine, Middle Aged, Critical Care and Intensive Care Medicine, Peritoneal Dialysis, Aged, Retrospective Studies

الوصف: The chronic kidney disease-mineral and bone disorder（CKD-MBD) is known to be associated with increased mortality in dialysis patients, but whether current global guidelines for CKD-MBD, which were primarily developed from hemodialysis, are suitable for peritoneal dialysis (PD) patients practice require further investigation.This is a single-center retrospective cohort study. In total 491 prevalent PD patients (median follow-ups: 34 months) from Peking Union Medical College Hospital (PUMCH) from January 2004 to December 2017 were included and followed until 30 June 2018. In the first dialysis year, the average levels of serum calcium, albumin-corrected calcium (CorCa), phosphorus, and parathyroid hormone (PTH) levels were the interested predictors in Cox proportional regression model.Of these PD patients (age 58 ± 17 years), 52% were male and 36% had diabetic nephropathy. In Cox regression over first-year mean parameters, PTH100 pg/mL (HR = 1.97, 95% CI 1.32 to 2.94,As one of the largest PD cohort study focusing on CKD-MBD, we demonstrated that the level of CKD-MBD markers in the first PD year are independent predictors of all-cause mortality. PTH 100-300 pg/mL might be the best target for Chinese PD patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae1a202e1eddab5928f149511f52c27Test
https://pubmed.ncbi.nlm.nih.gov/35380083Test

المؤلفون: Yu-Min Wang, Chunming Ding, Zong-Rui Li, Sui-Dan Chen, Ming-Hua Zheng, Miao-Miao Ying, Jian Wu, Gang Xu, Hong-Lei Ma

المصدر: Clinical and Molecular Hepatology
Clinical and Molecular Hepatology, Vol 27, Iss 2, Pp 329-345 (2021)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Steatosis, Inflammation, Lipocalin, Gastroenterology, digestive system, 03 medical and health sciences, Mice, 0302 clinical medicine, Lipocalin-2, Fibrosis, Non-alcoholic Fatty Liver Disease, Internal medicine, Nonalcoholic fatty liver disease, medicine, Animals, Humans, lcsh:RC799-869, Nonalcoholic steatohepatitis, Molecular Biology, Hepatology, business.industry, Area under the curve, nutritional and metabolic diseases, Middle Aged, medicine.disease, digestive system diseases, 030104 developmental biology, Liver, Biomarker (medicine), lcsh:Diseases of the digestive system. Gastroenterology, 030211 gastroenterology & hepatology, Alcoholic fatty liver, Original Article, Female, medicine.symptom, business, Biomarkers

الوصف: Background/Aims: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis. We aimed to investigate the usefulness of a key biomarker, lipocalin-2 (LCN2), for the detection of NASH progression.Methods: A mouse NASH model was established using a high-fat diet and a high-sugar drinking water. Gene expression profile of the NASH model was analyzed using RNA sequencing. Moreover, 360 NAFLD patients (steatosis, 83; NASH, 277), 40 healthy individuals, and 87 patients with alcoholic fatty liver disease were recruited.Results: Inflammatory infiltration, focal necrosis in the leaflets, steatosis, and fibrosis were documented in the mouse liver. In total, 504 genes were differentially expressed in the livers of NASH mice, and showed significant functional enrichment in the inflammation-related category. Upregulated liver LCN2 was found to be significantly interactive with various interleukins and toll-like receptors. Serum LCN2 levels were significantly increased in NAFLD patients. Serum LCN2 levels were correlated with steatosis, intralobular inflammation, semiquantitative fibrosis score, and nonalcoholic fatty liver disease activity score. The area under the curve of serum LCN2 was 0.987 with a specificity of 100% and a sensitivity of 93.5% for NASH diagnosis, and 0.977 with almost the same specificity and sensitivity for steatosis.Conclusions: LCN2 might be involved in the transition from NAFL to NASH by mediating inflammation. Serum LCN2 levels might be a novel biomarker for the diagnosis of NASH.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b28ed8612b09e08e58648e04de49e1Test
http://europepmc.org/articles/PMC8046622Test