المؤلفون: Ceci F., Oprea-Lager D. E., Emmett L., Adam J. A., Bomanji J., Czernin J., Eiber M., Haberkorn U., Hofman M. S., Hope T. A., Kumar R., Rowe S. P., Schwarzenboeck S. M., Fanti S., Herrmann K.

المساهمون: Ceci F., Oprea-Lager D.E., Emmett L., Adam J.A., Bomanji J., Czernin J., Eiber M., Haberkorn U., Hofman M.S., Hope T.A., Kumar R., Rowe S.P., Schwarzenboeck S.M., Fanti S., Herrmann K.

مصطلحات موضوعية: Consensus panel, EANM guideline, Prostate cancer guideline, PSMA prostate cancer, PSMA-PET, Structured report, Human, Male, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Reproducibility of Result, Nuclear Medicine, Prostatic Neoplasms

الوصف: Rationale: The development of consensus guidelines for interpretation of Prostate-Specific Membrane Antigen (PSMA)-Positron Emission Tomography (PET) is needed to provide more consistent reports in clinical practice. The standardization of PSMA-PET interpretation may also contribute to increasing the data reproducibility within clinical trials. Finally, guidelines in PSMA-PET interpretation are needed to communicate the exact location of findings to referring physicians, to support clinician therapeutic management decisions. Methods: A panel of worldwide experts in PSMA-PET was established. Panelists were selected based on their expertise and publication record in the diagnosis or treatment of PCa, in their involvement in clinical guidelines and according to their expertise in the clinical application of radiolabeled PSMA inhibitors. Panelists were actively involved in all stages of a modified, nonanonymous, Delphi consensus process. Results: According to the findings obtained by modified Delphi consensus process, panelist recommendations were implemented in a structured report for PSMA-PET. Conclusions: The E-PSMA standardized reporting guidelines, a document supported by the European Association of Nuclear Medicine (EANM), provide consensus statements among a panel of experts in PSMA-PET imaging, to develop a structured report for PSMA-PET in prostate cancer and to harmonize diagnostic interpretation criteria.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33604691; info:eu-repo/semantics/altIdentifier/wos/WOS:000619415600001; volume:48; issue:5; firstpage:1626; lastpage:1638; numberofpages:13; journal:EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING; http://hdl.handle.net/2318/1850528Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85101080430

الإتاحة: https://doi.org/10.1007/s00259-021-05245-yTest
http://hdl.handle.net/2318/1850528Test

المؤلفون: Em, Prvulovich, Durval C. Costa, Bomanji J, Ga, Clarke, Ce, Townsend, Rf, Miller, Pj, Ell

المصدر: Europe PubMed Central

مصطلحات موضوعية: Adult, Heart Neoplasms, Male, Tomography, Emission-Computed, Single-Photon, AIDS-Related Opportunistic Infections, Humans, Gallium Radioisotopes, Lymphoma, T-Cell, Lung, Magnetic Resonance Imaging, Pericardium, Lymphoma, AIDS-Related, Mycobacterium avium-intracellulare Infection

الوصف: A 33-yr-old homosexual man with acquired immune deficiency syndrome (AIDS) and Mycobacterium avium intracellulare (MAI) infection presented with fever, sweats, lethargy and dyspnea. A chest radiograph showed cardiomegaly and an echocardiograph revealed a large pericardial effusion. After pericardial aspiration, which confirmed T cell non-Hodgkin's lymphoma, he remained dyspneic. Gallium-67 imaging was performed to determine whether the patient's residual dyspnea was related to pulmonary MAI infection or lymphomatous infiltration of the heart. Planar 67Ga scintigraphy revealed intense tracer uptake in two areas within the mediastinum and surrounding the entire heart shadow but no evidence of pulmonary MAI infection. SPECT 67Ga scintigraphy precisely localized the two mediastinal abnormalities and demonstrated the tracer uptake around the heart to be pericardial rather than myocardial. Gallium-67 scintigraphy suggested that pericardial lymphoma was the likely basis of the patient's dyspnea.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d1f0576866e3a58e6efa722be36ada62Test
https://pubmed.ncbi.nlm.nih.gov/8683331Test

المؤلفون: Bomanji, J., Hungerford, J. L., Granowska, M., Britton, K. E.

مصطلحات موضوعية: Adult, Male, Choroid Neoplasms, Humans, sense organs, Middle Aged, Radionuclide Imaging, Melanoma, eye diseases, Research Article

الوصف: The possibility of using radiolabelled monoclonal antibody fragments to image uveal melanomas has been assessed in a pilot study. 99mTc labelled F(ab')2 fragments of MoAb 225.28S raised against cutaneous melanomas were used. Initially 10 patients were imaged. In five patients the clinical findings were typical of uveal melanoma. Immunoscintigraphy was positive in all five cases. In a further five patients there was doubt about the diagnosis. One was though to have a choroidal haemangioma but failed to respond to treatment and immunoscintigraphy was positive, suggesting a diagnosis of melanoma. Two patients were assigned a diagnosis of choroidal haemangioma, one of melanocytoma or possible retinal pigment epithelium carcinoma, and one of metastasis. Immunoscintigraphy was negative in all these four cases. In combination with established diagnostic tests immunoscintigraphy may have a part to play in differentiating uveal melanoma from other similar tumours.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::d7be81bede92971233d839b767772f9cTest
https://europepmc.org/articles/PMC1041268Test/

المؤلفون: Mumtaz, H., Bomanji, J. B., Gupta, N. K., Davidson, T., Durval C. Costa, Taylor, I., Ell, P. J.

المصدر: Scopus-Elsevier

مصطلحات موضوعية: Aged, 80 and over, Male, Tomography, Emission-Computed, Single-Photon, Heart Diseases, Coronary Disease, Heart, Middle Aged, Prognosis, Thallium Radioisotopes, Postoperative Complications, Predictive Value of Tests, Abdomen, Preoperative Care, cardiovascular system, Humans, Female, Prospective Studies, Research Article, Aged

الوصف: The prognostic value of myocardial perfusion scintigraphy is beginning to be recognised in patients undergoing cardiovascular surgery. The aim of this prospective study was to assess the predictive value of scintigraphy in elderly patients undergoing major non-vascular abdominal surgery. Adenosine stress thallium-201 (201Tl) single-photon emission tomography (SPET) was employed for imaging using a standard protocol. Patients over the age of 60 years (n = 55) with an intermediate to high likelihood of coronary artery disease were evaluated prospectively. The clinical outcome variables analysed were cardiac mortality and major cardiac morbidity occurring within 30 days of surgery. Cardiac events were cardiac death (n = 5), angina pectoris (n = 5), nonfatal mycardial infarction (n = 1), acute left ventricular failure (n = 2) and arrhythmias requiring treatment (n = 4). All cardiac events occurred in the first 10 postoperative days except one cardiac death which happened on the 29th postoperative day. Patients with an abnormal 201Tl SPET scan had a higher risk of postoperative death (4 vs 1) or any postoperative cardiac event (13 patients vs 4 patients; P < 0.0001) when compared with those with a normal scan. The sensitivity, specificity and positive predictive value of 201Tl imaging for perioperative ischaemia and adverse outcomes were 76%, 82% and 65%, respectively. The occurrence of an intraoperative event (P < 0.02) and the length of surgery (P < 0.01) were also predictors of a postoperative cardiac event. Clinical risk variables and an abnormal electrocardiogram in isolation were poor predictors. In conclusion, preoperative myocardial perfusion scintigraphy is a valuable technique for identifying elderly patients with a high risk for cardiac events when undergoing major non-vascular abdominal surgery.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1d84f2b54543fabeb30726ca9d2a3368Test
http://www.scopus.com/inward/record.url?eid=2-s2.0-10144237204&partnerID=MN8TOARSTest

المؤلفون: Sarah Schwarzenboeck, Steven P. Rowe, Francesco Ceci, Louise Emmett, Judit A. Adam, Ken Herrmann, Uwe Haberkorn, Thomas A. Hope, Rajesh Kumar, Michael S Hofman, Daniela E. Oprea-Lager, Johannes Czernin, Jamshed Bomanji, Stefano Fanti, Matthias Eiber

المساهمون: Radiology and Nuclear Medicine, CCA -Cancer Center Amsterdam, Ceci F, Oprea-Lager DE, Emmett L, Adam JA, Bomanji J, Czernin J, Eiber M, Haberkorn U, Hofman MS, Hope TA, Kumar R, Rowe SP, Schwarzenboeck SM, Fanti S, Herrmann K, Radiology and nuclear medicine, CCA - Imaging and biomarkers

المصدر: European journal of nuclear medicine and molecular imaging, vol 48, iss 5
European journal of nuclear medicine and molecular imaging, 48(5), 1626-1638. Springer Verlag
Ceci, F, Oprea-Lager, D E, Emmett, L, Adam, J A, Bomanji, J, Czernin, J, Eiber, M, Haberkorn, U, Hofman, M S, Hope, T A, Kumar, R, Rowe, S P, Schwarzenboeck, S M, Fanti, S & Herrmann, K 2021, ' E-PSMA: the EANM standardized reporting guidelines v1.0 for PSMA-PET ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 48, no. 5, pp. 1626-1638 . https://doi.org/10.1007/s00259-021-05245-yTest
European Journal of Nuclear Medicine and Molecular Imaging, 48(5), 1626-1638. Springer Verlag
European Journal of Nuclear Medicine and Molecular Imaging

مصطلحات موضوعية: Male, Structured report, Urologic Diseases, medicine.medical_specialty, Standardization, PSMA prostate cancer, Clinical Sciences, Medizin, Modified delphi, Consensus panel, EANM guidelines, Prostate cancer guidelines, PSMA-PET, Humans, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Reproducibility of Results, Nuclear Medicine, Prostatic Neoplasms, Guidelines, urologic and male genital diseases, Structured reporting, Medicine, Radiology, Nuclear Medicine and imaging, Medical physics, Neoplasm Staging, Membrane antigen, computer.programming_language, Cancer, business.industry, Prostate Cancer, General Medicine, ddc, Consensus panel, PSMA-PET, Clinical trial, Clinical Practice, Other Physical Sciences, Nuclear Medicine & Medical Imaging, Psma pet, Lymph Node Excision, Biomedical Imaging, Lymph Nodes, business, computer, Delphi

الوصف: Rationale The development of consensus guidelines for interpretation of Prostate-Specific Membrane Antigen (PSMA)-Positron Emission Tomography (PET) is needed to provide more consistent reports in clinical practice. The standardization of PSMA-PET interpretation may also contribute to increasing the data reproducibility within clinical trials. Finally, guidelines in PSMA-PET interpretation are needed to communicate the exact location of findings to referring physicians, to support clinician therapeutic management decisions. Methods A panel of worldwide experts in PSMA-PET was established. Panelists were selected based on their expertise and publication record in the diagnosis or treatment of PCa, in their involvement in clinical guidelines and according to their expertise in the clinical application of radiolabeled PSMA inhibitors. Panelists were actively involved in all stages of a modified, nonanonymous, Delphi consensus process. Results According to the findings obtained by modified Delphi consensus process, panelist recommendations were implemented in a structured report for PSMA-PET. Conclusions The E-PSMA standardized reporting guidelines, a document supported by the European Association of Nuclear Medicine (EANM), provide consensus statements among a panel of experts in PSMA-PET imaging, to develop a structured report for PSMA-PET in prostate cancer and to harmonize diagnostic interpretation criteria.

وصف الملف: application/pdf; STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429a7604c8b4154c55513d992f347b7eTest
https://escholarship.org/uc/item/9dh1h4gcTest

المؤلفون: Mohsen Beheshti, Jamshed Bomanji, Stefano Fanti, Monica Celli, Athar Haroon, Rasoul Zakavi, Mark Emberton, Werner Langsteger, Lucia Zanoni

المساهمون: Haroon A, Zanoni L, Celli M, Zakavi R, Beheshti M, Langsteger W, Fanti S, Emberton M, Bomanji J.

المصدر: Nuclear Medicine Communications. 36:1065-1075

مصطلحات موضوعية: Adult, Male, 11C-choline, Fluorine Radioisotopes, Pathology, medicine.medical_specialty, Statistics as Topic, Multimodal Imaging, Choline, chemistry.chemical_compound, Humans, Medicine, Distribution (pharmacology), Tissue Distribution, Radiology, Nuclear Medicine and imaging, Carbon Radioisotopes, Aged, Retrospective Studies, Aged, 80 and over, Multimodal imaging, medicine.diagnostic_test, business.industry, Biological Transport, General Medicine, Middle Aged, Extraprostatic, 11C-choline, 18F-methylcholine, 18F-ethylcholine, chemistry, Multicenter study, Positron emission tomography, Male patient, Positron-Emission Tomography, Tomography, X-Ray Computed, business

الوصف: AIM: The aim of the study was to evaluate the visceral localization of the three most commonly used choline-based radiotracers (C-choline, F-methylcholine, and F-ethylcholine) with the aim of analyzing uptake in metabolically and anatomically disease-free patients. MATERIALS AND METHODS: A total of 1250 standardized uptake values (SUVmax, SUVmean) were analyzed in 45 anatomical regions in 45 patients (15 patients with C-choline, 15 with F-methylcholine, and 15 with F-ethylcholine). These patients were selected from a cohort of 3721 choline PET/computed tomography studies performed at three teaching hospitals over a period of 10 years. They had no evidence of metabolically active primary disease, metastatic disease, or altered morphology on the computed tomography component of the study or any evidence of disease elsewhere on other imaging modalities. The sites of primary disease (prostate and seminal vesicles) were excluded from evaluation. RESULTS: No adverse effect was documented when using the three tracers. Visceral localization was the same for all three tracers. Viscera with a statistical difference in intensity of uptake included the choroid plexus (P=0.0001), occipital lobe (P=0.014), parietal lobe (P=0.008), cerebellum (P=0.003), parotid gland (P=0.005), submandibular gland (P=0.001), tonsils (P=0.001), thyroid (P=0.0001), lungs (P=0.001), aorta (P=0.001), pulmonary artery (P=0.0001), liver segments I (P=0.005), III (P=0.005), IVB (P=0.03), and V (P=0.01), spleen [hilum (P=0.0009), body (P=0.0001)], pancreas [head (P=0.0001), body (P=0.01), tail (P=0.002)], esophagus (P=0.001), stomach (P=0.0001), duodenum (P=0.0002), large intestine (P=0.008), and rectum (P=0.0001). Elsewhere, no statistical difference was observed. Excreted activity was noted in the kidneys and bladder. CONCLUSION: This study demonstrates that the visceral localization of C-choline, F-methylcholine, and F-ethylcholine in disease-free patients is similar. Depending on the tracer uptake pattern, the viscera can be divided into two distinct categories: those with a statistically significant difference in uptake and those with no difference in uptake. The study outlines the range of SUVs for various organs for the three tracers and identifies some of the potential pitfalls in the evaluation of 'nonavid' but clinically significant presentation of different disease entities.

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed27b3de73c02f20647b2aa1e3eebe96Test
https://doi.org/10.1097/mnm.0000000000000372Test

المؤلفون: Mark Emberton, Hikmat Jan, Soujanya Nuthakki, Stefano Fanti, Jamshed Bomanji, Lorenzo Biassoni, Sobhan Vinjamuri, Alex Freeman, Asim Afaq, Athar Haroon, Mohsen Beheshti

المساهمون: Haroon A, Afaq A, Nuthakki S, Freeman A, Biassoni L, Fanti S, Beheshti M, Jan H, Vinjamuri S, Emberton M, Bomanji J.

مصطلحات موضوعية: Male, medicine.medical_specialty, Gallium Radioisotopes, 030218 nuclear medicine & medical imaging, Choline, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Periprostatic, Prostate, Positron Emission Tomography Computed Tomography, medicine, Organometallic Compounds, Humans, Radiology, Nuclear Medicine and imaging, MRI, 68Ga-PSMA, DOTATATE, Rhabdomyosarcoma, Edetic Acid, Gallium Isotopes, PET-CT, business.industry, Malakoplakia, General Medicine, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Phenotype, 030220 oncology & carcinogenesis, Radiology, Molecular imaging, Differential diagnosis, business, Oligopeptides

الوصف: The objective of this study was to highlight the role of multimodality imaging and present the differential diagnosis of abnormal tracer accumulation in the prostate and periprostatic tissue. Our departments have performed molecular imaging of the prostate utilizing PET-CT and PET-MRI with a range of biomarkers including F-FDG, radiolabelled choline, Ga-DOTATATE PET-CT and Ga-PSMA images. We retrospectively reviewed the varying appearances of the prostate gland in different diseases and incidental findings in periprostatic region. The differential diagnosis of pathologies related to prostate and periprostatic tissue on multimodality imaging includes malakoplakia, rhabdomyosarcoma, lymphoma, prostate cancer, neuroendocrine tumours, uchida changes, rectoprostatic fistula, synchronous malignancies, lymphocoele and schwanoma. There exists a wide differential for abnormal tracer accumulation in the prostate gland. As a radiologist and nuclear medicine physician, it is important to be aware of range of prostatic and periprostatic pathologies.

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150a5a1e8a5684f19ba53d7b7cde3f4bTest
http://hdl.handle.net/11585/661658Test