نتائج البحث - "Lactate dehydrogenase"

1

CYFRA21-1 is a more sensitive biomarker to assess the severity of pulmonary alveolar proteinosis

المؤلفون: Shui-Yi Gu, Jiuwu Bai, Hai-Wen Lu, Xiaoli Sun, Shu Liang, Jinfu Xu

المصدر: BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-8 (2022)
BMC Pulmonary Medicine

الوصف: Background Serum lactate dehydrogenase (LDH), carcinoembryonic antigen (CEA) and CYFRA21-1 are the commonly used biomarkers to identify patients with autoimmune pulmonary alveolar proteinosis (APAP). However, it is not clear which of the biomarkers is more sensitive to the severity of the patient’s condition. Methods APAP patients numbering 151 were enrolled in this study. All patients’ severity was assessed through the severity and prognosis score of PAP (SPSP). According to the respective laboratory upper limits of serum levels of LDH, CEA and CYFRA21-1, APAP patients were divided into higher and lower-level groups. Patients were divided into five groups based on SPSP. 88 patients had completed six months of follow-up. We calculated sensitivity, specificity, and critical point of LDH, CEA and CYFRA21-1 between APAP patients and normal control group, and between grade 1–2 and 3–5 through receiving operating characteristics (ROC) curve. Results Serum LDH, CEA and CYFRA21-1 levels of patients with PAP were higher and distinctly related to PaO2, FVC, FEV1, DLCO, HRCT scores and SPSP. The SPSP of patients in higher-level LDH, CEA and CYFRA21-1 groups were higher than those of corresponding lower-level groups. Based on SPSP results, the patients were divided into five groups (grade I, 20; grade II, 37; grade III, 40; grade IV, 38; grade V, 16). The serum level of CYFRA21-1 of patients with APAP in grade II was higher than that of patients in grade I and lower than that of patients in grade III. Serum CYFRA21-1 of patients with APAP after six months were higher than the baseline among the aggravated group. Serum LDH, CEA and CYFRA21-1 levels after six months among patients in the relieved group of patients with APAP were lower than the baseline. ROC correlating LDH, CEA and CYFRA21-1 values with APAP severity (between grade 1–2 and 3–5) showed an optimal cutoff of LDH of over 203 U/L ( 3.3 ng/ml) (AUC: 0.815, 95% CI [0.748–0.882], sensitivity: 0.606, specificity: 0.877). Conclusion Serum CYFRA21-1 level was more sensitive in revealing the severity of APAP than LDH and CEA levels among mild to moderate forms of disease.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc99e2fdf0b2af88555e9826ea282828Test
https://doaj.org/article/354038660885429c89622bd4ec94a678Test

2

Interleukin‐6 and lactate dehydrogenase expression in a novel ex vivo rocking model of equine corneal epithelial wound healing

المؤلفون: Rachel A. Allbaugh, Anumantha G. Kanthasamy, Gil Ben-Shlomo, Adhithiya Charli, Rita F. Wehrman, Ulrike Genschel

المصدر: Veterinary Ophthalmology. 24:509-519

الوصف: PURPOSE To establish a physiologically relevant ex vivo model of equine corneal epithelial wound healing. METHODS Fourteen equine corneas were randomly assigned to one of two groups: wounded (n = 8) or unwounded (n = 6) controls. In the wounded group, the axial corneal epithelium was removed by applying a 6 mm filter paper disk soaked in 1N-NaOH for 60 s. Corneas were subsequently cultured using an air-liquid interface model. Evaluation of corneal healing was performed daily, and culture medium was collected. Corneas were randomly assigned to undergo processing via histopathology and RNAscope in situ hybridization for interleukin-6 (IL-6) and alpha-smooth muscle actin (αSMA) expression at T24, T48, and T72 h after wounding. Media of the cultured corneas were evaluated for the presence of lactate dehydrogenase (LDH) by a colorimetric assay. RESULTS The ulcerated area of the wounded corneas decreased over time and all corneas healed within 72 h. Histologically, normal corneal architecture was observed including healthy epithelium (in areas other than the ulcerated ones), minimal stromal edema, intact endothelium, and Descemet's membrane. IL-6 expression was increased in wounded corneas compared with unwounded controls. LDH expression was elevated for both wounded and unwounded corneas at T24 but decreased substantially and was not detected at T48 in media from wounded and unwounded corneas, respectively. No αSMA expression was detected from either wounded or unwounded corneas. CONCLUSIONS The equine air-liquid interface, ex vivo, corneal epithelial wound healing model is effective and physiologically relevant. This model can be used in future studies evaluating various corneal therapies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea192aadfdfee5204f426e8a84a2438eTest
https://doi.org/10.1111/vop.12935Test

3

دورية أكاديمية

Effects of certolizumab on cerulein-Ä±nduced acute pancreatitis in rats

المؤلفون: KÃ¶sekli, M.A., Ozmen, O., Sahinduran, S., Yilmaz, Mustafa, Ã‡obankara, Veli, Sungurtekin, UÄŸur

الوصف: Objectives To evaluate the effects of certolizumab, a pegylated monoclonal antibody to tumor necrosis factor ? (TNF-?), on experimentally induced acute pancreatitis. Methods Healthy Wistar Albino male rats (n = 36) were randomly divided into 4 groups (9 rats in each group): group 1, control group; group 2, certolizumab group; group 3, cerulein group; and group 4, cerulein + certolizumab group. Acute edematous pancreatitis was induced via intraperitoneal injection of 80-Âµg/kg cerulein (20 Âµg/kg, 4 times at 1-hour intervals) in groups 3 and 4. Certolizumab (10 Âµg) was intraperitoneally administered in groups 2 and 4. Serum levels of amylase, lipase, TNF-?, and lactate dehydrogenase were evaluated. Histopathology and immunohistochemistry of the pancreatic tissue for assessing the activities of malondialdehyde, myeloperoxidase, TNF-?, and caspase-3 were also performed after 72 hours. Results Certolizumab treatment significantly decreased the serum levels of amylase, lipase, and lactate dehydrogenase. Histopathological edema, hemorrhage, parenchymal necrosis, and infiltration scores were also decreased, along with a decrease in malondialdehyde, myeloperoxidase, TNF-?, and caspase-3 activities. Conclusion This study suggests that certolizumab is a beneficial treatment mode for reducing the severity of acute pancreatitis. Copyright Â© 2016 Wolters Kluwer Health, Inc. All rights reserved.

العلاقة: Pancreas; Makale - UluslararasÄ± Hakemli Dergi - Kurum Ã–ÄŸretim ElemanÄ±; https://hdl.handle.net/11499/9456Test; https://doi.org/10.1097/MPA.0000000000000660Test; 45; 1120; 1125; 2-s2.0-84966714181; WOS:000382322200010

الإتاحة: https://doi.org/10.1097/MPA.0000000000000660Test
https://hdl.handle.net/11499/9456Test

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4

Robust, quick, and convenient intraoperative method to differentiate parathyroid tissue

المؤلفون: Dai Takeuchi, Takahiro Inaishi, Noriyuki Miyajima, Masahiro Shibata, Toyone Kikumori

المصدر: Surgery. 167(2):385-389

الوصف: Background: Identification of parathyroid tissue during surgery is necessary for its preservation in situ or for autotransplantation to avoid postoperative hypoparathyroidism. Frozen sections are the gold standard for distinguishing parathyroid tissue from other tissues during thyroidectomy. Although frozen sections are very accurate, they are costly and require pathologists and technical staff. Parathyroid tissue is rich in mitochondria, which harbor Krebs-cycle enzymes such as aspartate aminotransferase. In contrast, lactate dehydrogenase is expressed ubiquitously. These 2 enzymes are measured routinely as “leaked” enzymes. We hypothesized that the aspartate aminotransferase–to–lactate dehydrogenase ratio in suspended tissue could distinguish parathyroid tissue from other tissues. Methods: We analyzed 94 specimens (43 parathyroid, 19 thyroid cancers, 13 normal lymph nodes, 10 adipose, 6 thyroid, and 3 miscellaneous tissues) from 55 patients who underwent thyroid or parathyroid surgery between March 2018 and June 2019 in our institution. Trace amounts of remnant parathyroid tissue from autotransplantation specimens were suspended in 1 mL of normal saline and measured for aspartate aminotransferase and lactate dehydrogenase. Approximately 1 mm3 of apparently distinct tissue minced by scissors (eg, thyroid gland, metastatic lymph node, etc) or washouts of needles used for preoperative aspiration biopsy were also measured for comparison. Results: The aspartate aminotransferase–to–lactate dehydrogenase ratios in suspended parathyroid tissue specimens were consistently greater than those of other tissues (P < .001, Mann-Whitney test); 0.27 was the optimal cutoff value with 100% sensitivity and specificity. Conclusion: This method distinguished parathyroid tissue quickly and conveniently from other tissues intraoperatively with minimum cost and without dedicated pathologic staff. This methodology may serve useful in decreasing the incidence of postoperative hypoparathyroidism, especially in settings with limited access to pathologists.
ファイル公開：2021-02-01

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43a7cd908ed564dffafe237659841f1Test
https://nagoya.repo.nii.ac.jp/records/30104Test

5

Lactate dehydrogenase activity staining demonstrates time-dependent immune cell infiltration in human ex-vivo burn-injured skin

المؤلفون: Laptin Ho, Gongjie Wu, Declan Collins, Sundhiya Mandalia, Justin Weir, Zoltan Takats, Ashley Spencer, Joshua Cuddihy, István Nagy, Hiromi Kudo, Andreas Dannhorn, Marcela P. Vizcaychipi

المساهمون: Westminster Medical School Research Trust

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports

مصطلحات موضوعية: Adult, Male, Burn injury, Pathology, medicine.medical_specialty, Cell type, Time Factors, Biopsy, Science, Inflammation, Article, Imaging, Young Adult, chemistry.chemical_compound, INFLAMMATION, Lactate dehydrogenase, medicine, Humans, Lymphocytes, Viability assay, Analytical biochemistry, Aged, Skin, Aged, 80 and over, Multidisciplinary, Science & Technology, L-Lactate Dehydrogenase, Mass spectrometry, Chemistry, Macrophages, Middle Aged, medicine.disease, Lymphocyte Subsets, Enzyme Activation, Skin diseases, Cellular infiltration, Multidisciplinary Sciences, Hypermetabolism, Medicine, Science & Technology - Other Topics, Female, Disease Susceptibility, medicine.symptom, Burns, Biomarkers, Ex vivo

الوصف: Burn injuries constitute one of the most serious accidental injuries. Increased metabolic rate is a hallmark feature of burn injury. Visualising lactate dehydrogenase (LDH) activity has been previously used to identify metabolic activity differences, hence cell viability and burn depth in burn skin. LDH activity was visualised in injured and uninjured skin from 38 sub-acute burn patients. LDH activity aided the identification of spatially correlating immunocompetent cells in a sub-group of six patients. Desorption Electrospray Ionisation Mass Spectrometry Imaging (DESI MSI) was used to describe relative lactate and pyruvate abundance in burned and uninjured tissue. LDH activity was significantly increased in the middle and deep regions of burnt skin compared with superficial areas in burnt skin and uninjured tissue and positively correlated with post-burn time. Regions of increased LDH activity showed high pyruvate and low lactate abundance when examined with DESI-MSI. Areas of increased LDH activity exhibited cellular infiltration, including CD3 + and CD4 + T-lymphocytes and CD68 + macrophages. Our data demonstrate a steady increase in functional LDH activity in sub-acute burn wounds linked to cellular infiltration. The cell types associated are related to tissue restructuring and inflammation. This region in burn wounds is likely the focus of dysregulated inflammation and hypermetabolism.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6125819aa4f88d237cb9414ce4fe0bf0Test
http://hdl.handle.net/10044/1/92656Test

6

دورية أكاديمية

CD5 as a prognostic marker in patients with diffuse large B-cell lymphoma: a multicenter study

المؤلفون: Kırkızlar H.O., Demirci U., Ümit E.G., Gürsoy V., Pınar İ.E., Özkalemkaş F., Güven Z.T.

الوصف: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) and comprises a heterogeneous group of disease. While classification of B-cell lymphomas has been evolving to include clonality in a specific manner, morphology, and immunohistochemistry remain the backbone. We aimed to evaluate the value of CD5 expression on disease characteristics as well as prognosis in patients with DLBCL. Data of 131 patients with DLBCL with CD5 positivity and as a comparison arm, data of 129 patients with DLBCL without CD5 positivity were evaluated. Mean age was 59 and 55.7% of the patients were male. Overall survival was 29.8 months. Poor prognostic factors including (high-LDH levels, B symptoms, low ECOG score, high R-IPI and NCCN-IPI score) were observed to be significantly related with CD5 positivity. Mean survival in CD5 positive patients were 29.8 months, which is significantly shorter than the general DLBCL survival worldwide. CD5 expression shall be evaluated in all samples of DLBCL patients due to its possible effects on outcomes. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

العلاقة: Journal of Hematopathology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11454/79471Test; https://doi.org/10.1007/s12308-022-00523-6Test; 15; 203; 213

الإتاحة: https://doi.org/10.1007/s12308-022-00523-6Test
https://hdl.handle.net/11454/79471Test

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7

دورية أكاديمية

CD5 as a prognostic marker in patients with diffuse large B-cell lymphoma: a multicenter study

المؤلفون: Demirci U., Kırkızlar H.O., Ümit E.G., Gürsoy V., Pınar İ.E., Özkalemkaş F., Güven Z.T.

الوصف: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) and comprises a heterogeneous group of disease. While classification of B-cell lymphomas has been evolving to include clonality in a specific manner, morphology, and immunohistochemistry remain the backbone. We aimed to evaluate the value of CD5 expression on disease characteristics as well as prognosis in patients with DLBCL. Data of 131 patients with DLBCL with CD5 positivity and as a comparison arm, data of 129 patients with DLBCL without CD5 positivity were evaluated. Mean age was 59 and 55.7% of the patients were male. Overall survival was 29.8 months. Poor prognostic factors including (high-LDH levels, B symptoms, low ECOG score, high R-IPI and NCCN-IPI score) were observed to be significantly related with CD5 positivity. Mean survival in CD5 positive patients were 29.8 months, which is significantly shorter than the general DLBCL survival worldwide. CD5 expression shall be evaluated in all samples of DLBCL patients due to its possible effects on outcomes. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

العلاقة: Journal of Hematopathology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1007/s12308-022-00523-6Test; https://hdl.handle.net/11454/85025Test; 15; 203; 213; 2-s2.0-85143634789

الإتاحة: https://doi.org/10.1007/s12308-022-00523-6Test
https://hdl.handle.net/11454/85025Test

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8

Monomorphic Epitheliotropic Intestinal T-cell Lymphoma Involving the Lung and Brain: A Rare Case Study

المصدر: Internal Medicine

الوصف: Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a primary intestinal T-cell lymphoma and other organ involvement is very rare. A rare case of MEITL involving the lung and brain is herein reported. The patient developed panperitonitis with a small intestinal perforation, and emergency surgery was performed. The pathological findings from the surgical specimens demonstrated atypical lymphoid cells which were positive for CD3, CD8, and CD56. Moreover, the pathological findings of lung specimens taken by bronchoscopy were consistent with those of the small intestine. It is therefore important to include the possibility of MEITL in the differential diagnosis of cancer patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f03fabedcae00ee3f45fe2501bf6317Test
https://doi.org/10.2169/internalmedicine.4710-20Test

9

Castleman hastalığı: Türkiye’den çok merkezli bir olgu serisi

المساهمون: İstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Celkan, Tulin Tiraje

مصطلحات موضوعية: lymph node biopsy, Male, plasma cell, Turkey, retrospective study, diarrhea, clinical outcome, thrombocytopenia, immunoglobulin A, hyalin, etoposide, Turkey (republic), computer assisted tomography, immunoglobulin G, case study, rituximab, middle aged, inguinal lymph node, Human herpesvirus 8, Child, siltuximab, fever, C reactive protein, Human immunodeficiency virus, acute phase protein, adult, prednisolone, clinical trial, Hematology, chronic kidney failure, lymph node, anemia, female, sweating, anorexia, histopathology, positron emission tomography-computed tomography, epidemiology, coronary artery disease, cyclophosphamide plus doxorubicin plus prednisolone plus rituximab plus vincristine, Castleman disease, overall survival, lenalidomide, olanzapine, interleukin 6, doxorubicin, vincristine, Article, histology, tocilizumab, hepatomegaly, demographics, turkey (bird), Unicentric, lymphadenopathy, cervical lymph node, follow up, Humans, cyclosporine, human, bendamustine, arthralgia, coughing, outcome assessment, Retrospective Studies, splenomegaly, abdominal pain, Kaposi sarcoma, lactate dehydrogenase, hypoalbuminemia, clinical assessment, major clinical study, methylprednisolone, body weight loss, human tissue, axillary lymph node, Treatment, multicenter study, Multicentric, lymphocytopenia, CD3 antigen, prednisone, excision, angiofollicular lymph node hyperplasia, cyclophosphamide, fatigue, pathology, erythrocyte sedimentation rate, Lymph Nodes

الوصف: Castleman disease (CD) is a rare disease also known as angiofollicular lymph node hyperplasia. The two main histological subtypes are the hyaline vascular and plasma cell variants. It is further classified as unicentric CD (UCD) or multicentric CD (MCD) according to the anatomical distribution of the disease and the number of lymph nodes involved. The aim of this multicenter study was to evaluate all cases of CD identified to date in Turkey to set up a national registry to improve the early recognition, treatment, and follow-up of CD.Both adult (n=130) and pediatric (n=10) patients with lymph node or involved field biopsy results reported as CD were included in the study. Patients’ demographic information, clinical and laboratory characteristics, imaging study results, treatment strategies, and clinical outcomes were evaluated retrospectively.A total of 140 patients (69 male and 71 female) with a diagnosis of UCD (n=73) or MCD (n=67) were included. The mean age was 39 years in the UCD group and 47 years in the MCD group. Female patients were more common in the UCD group. The most common histological subtype was hyaline vascular for both UCD and MCD patients. Asymptomatic patients were more common in the UCD group. Anemia, elevations of acute phase reactants, and hypoalbuminemia were more common in the MCD group. The most commonly used treatment strategies for UCD were surgical excision, rituximab, and radiotherapy, respectively. All UCD patients were alive at a median of 19.5 months of follow-up. The most commonly used treatment strategies for MCD were methyl prednisolone, R-CHOP, R-CVP, and rituximab. Thirteen MCD patients had died at a median of 34 months of follow-up.This study is important in presenting the patient characteristics and treatment strategies for CD from Turkey, with the potential of increasing awareness about CD. Treatment data may help in making decisions, particularly in countries that do not have access to siltuximab. However, larger prospective studies are needed to make definitive conclusions.Anjiyofolliküler lenf nodu hiperplazisi olarak da bilinen Castleman hastalığı (CH), nadir bir hastalık olup başlıca hiyalin vasküler ve plazma hücreli olmak üzere 2 histolojik alt tipi vardır. Hastalığın anatomik yayılımı ve tutulan lenf nodu bölgelerinin sayısına göre unisentrik (UCH) ya da multisentrik (MCH) olarak sınıflandırılır. Bu çok merkezli çalışmanın amacı bugüne kadar Türkiye’de tanımlanan tüm CH olgularını tanımlamak, ulusal bir veri tabanı oluşturarak CH’de erken tanı, tedavi ve takip sürecine katkı sağlamaktır.Çalışmaya lenf nodu ya da tutulan alandan yapılmış biyopsi sonucu CH olarak rapor edilen hem erişkin (n=130) hem de pediyatrik (n=10) hastalar dahil edildi. Hastaların demografik bilgileri, klinik ve laboratuvar özellikleri, görüntüleme bulguları, aldıkları tedaviler ve tedavi sonuçları geriye dönük olarak değerlendirildi.Dahil edilen 140 hastanın 69’u kadın, 71’i erkekti. Yetmiş üç hasta UCH, 67 hasta MCH olarak sınıflandırılmıştı. Yaş ortalaması UCH’de 39, MCH’de 47 yıl idi. Kadın hastalar UCH’de daha fazlaydı. Hem UCH hem de MCH için en sık histolojik alt tip hiyalin vaskülerdi. Asemptomatik hastalar UCH’de daha fazlaydı. Anemi, akut faz reaktanı yüksekliği ve hipoalbuminemi MCH’de daha sıktı. UCH’de en sık uygulanan tedaviler sırasıyla cerrahi eksizyon, rituksimab ve radyoterapiydi. Median 19,5 aylık takipte tüm UCH’li hastalar hayattaydı. MCH’de 1. basamak tedaviler metil prednizolon, R-CHOP, R-CVP ve rituksimab idi. Median 34 aylık takipte 13 MCH’li hasta kaybedilmişti.Çalışmamız Türkiye’deki CH hastalarının özellikleri ve tedavi yaklaşımlarını yansıtması açısından önemli olup hastalıkla ilgili farkındalığın arttırılması potansiyeline sahiptir. Tedavi verileri özellikle ülkemizde olduğu gibi siltuksimaba ulaşımı zor olan ülkelerde tedavi seçimi konusunda fikir verebilir. Kesin sonuçlar çıkarmak için büyük ölçekli prospektif çalışmalara ihtiyaç vardır.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1355213137d9a3af624c19cb8a3db66Test
https://avesis.deu.edu.tr/publication/details/c06ffedc-d6b2-4d2c-9f3f-50f856e787e1/oaiTest

10

CD5 as a prognostic marker in patients with diffuse large B-cell lymphoma: a multicenter study

مصطلحات موضوعية: Histology, protein bcl 2, overall survival, very elderly, interferon regulatory factor 4, CD 5, protein bcl 6, Article, Pathology and Forensic Medicine, male, Double/triple expressor, human, fluorescence in situ hybridization, CD20 antigen, progression free survival, cyclophosphamide plus doxorubicin plus etoposide plus prednisolone plus rituximab plus vincristine, ECOG Performance Status, adult, lactate dehydrogenase, Hematology, Diffuse large B-cell lymphoma, CNS prophylaxis, major clinical study, diffuse large B cell lymphoma, CD5 antigen, aged, c-MYC, common acute lymphoblastic leukemia antigen, female, Myc protein, CD3 antigen, Ki 67 antigen, pathology, prognosis, cyclophosphamide plus doxorubicin plus prednisolone plus rituximab plus vincristine

الوصف: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) and comprises a heterogeneous group of disease. While classification of B-cell lymphomas has been evolving to include clonality in a specific manner, morphology, and immunohistochemistry remain the backbone. We aimed to evaluate the value of CD5 expression on disease characteristics as well as prognosis in patients with DLBCL. Data of 131 patients with DLBCL with CD5 positivity and as a comparison arm, data of 129 patients with DLBCL without CD5 positivity were evaluated. Mean age was 59 and 55.7% of the patients were male. Overall survival was 29.8 months. Poor prognostic factors including (high-LDH levels, B symptoms, low ECOG score, high R-IPI and NCCN-IPI score) were observed to be significantly related with CD5 positivity. Mean survival in CD5 positive patients were 29.8 months, which is significantly shorter than the general DLBCL survival worldwide. CD5 expression shall be evaluated in all samples of DLBCL patients due to its possible effects on outcomes. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc5afcfe2c14a3c1913655d10fc99b8Test
https://hdl.handle.net/11454/79471Test

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