دورية أكاديمية

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

التفاصيل البيبلوغرافية
العنوان: Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
المؤلفون: Mullins N., Forstner A. J., O'Connell K. S., Coombes B., Coleman J. R. I., Qiao Z., Als T. D., Bigdeli T. B., Borte S., Bryois J., Charney A. W., Drange O. K., Gandal M. J., Hagenaars S. P., Ikeda M., Kamitaki N., Kim M., Krebs K., Panagiotaropoulou G., Schilder B. M., Sloofman L. G., Steinberg S., Trubetskoy V., Winsvold B. S., Won H. -H., Abramova L., Adorjan K., Agerbo E., Al Eissa M., Albani D., Alliey-Rodriguez N., Anjorin A., Antilla V., Antoniou A., Awasthi S., Baek J. H., Baekvad-Hansen M., Bass N., Bauer M., Beins E. C., Bergen S. E., Birner A., Bocker Pedersen C., Boen E., Boks M. P., Bosch R., Brum M., Brumpton B. M., Brunkhorst-Kanaan N., Budde M., Bybjerg-Grauholm J., Byerley W., Cairns M., Casas M., Cervantes P., Clarke T. -K., Cruceanu C., Cuellar-Barboza A., Cunningham J., Curtis D., Czerski P. M., Dale A. M., Dalkner N., David F. S., Degenhardt F., Djurovic S., Dobbyn A. L., Douzenis A., Elvsashagen T., Escott-Price V., Ferrier I. N., Fiorentino A., Foroud T. M., Forty L., Frank J., Frei O., Freimer N. B., Frisen L., Gade K., Garnham J., Gelernter J., Giortz Pedersen M., Gizer I. R., Gordon S. D., Gordon-Smith K., Greenwood T. A., Grove J., Guzman-Parra J., Ha K., Haraldsson M., Hautzinger M., Heilbronner U., Hellgren D., Herms S., Hoffmann P., Holmans P. A., Huckins L., Jamain S., Johnson J. S., Kalman J. L., Kamatani Y., Kennedy J. L., Kittel-Schneider S., Knowles J. A., Kogevinas M., Koromina M., Kranz T. M., Kranzler H. R., Kubo M., Kupka R., Kushner S. A., Lavebratt C., Lawrence J., Leber M., Lee H. -J., Lee P. H., Levy S. E., Lewis C., Liao C., Lucae S., Lundberg M., MacIntyre D. J., Magnusson S. H., Maier W., Maihofer A., Malaspina D., Maratou E., Martinsson L., Mattheisen M., McCarroll S. A., McGregor N. W., McGuffin P., McKay J. D., Medeiros H., Medland S. E., Millischer V., Montgomery G. W., Moran J. L., Morris D. W., Muhleisen T. W., O'Brien N., O'Donovan C., Olde Loohuis L. M., Oruc L., Papiol S., Pardinas A. F., Perry A., Pfennig A., Porichi E., Potash J. B., Quested D., Raj T., Rapaport M. H., DePaulo J. R., Regeer E. J., Rice J. P., Rivas F., Rivera M., Roth J., Roussos P., Ruderfer D. M., Sanchez-Mora C., Schulte E. C., Senner F., Sharp S., Shilling P. D., Sigurdsson E., Sirignano L., Slaney C., Smeland O. B., Smith D. J., Sobell J. L., Soholm Hansen C., Soler Artigas M., Spijker A. T., Stein D. J., Strauss J. S., Swiatkowska B., Terao C., Thorgeirsson T. E., Toma C., Tooney P., Tsermpini E. -E., Vawter M. P., Vedder H., Walters J. T. R., Witt S. H., Xi S., Xu W., Yang J. M. K., Young A. H., Young H., Zandi P. P., Zhou H., Zillich L., Adolfsson R., Agartz I., Alda M., Alfredsson L., Babadjanova G., Backlund L., Baune B. T., Bellivier F., Bengesser S., Berrettini W. H., Blackwood D. H. R., Boehnke M., Borglum A. D., Breen G., Carr V. J., Catts S., Corvin A., Craddock N., Dannlowski U., Dikeos D., Esko T., Etain B., Ferentinos P., Frye M., Fullerton J. M., Gawlik M., Gershon E. S., Goes F. S., Green M. J., Grigoroiu-Serbanescu M., Hauser J., Henskens F., Hillert J., Hong K. S., Hougaard D. M., Hultman C. M., Hveem K., Iwata N., Jablensky A. V., Jones I., Jones L. A., Kahn R. S., Kelsoe J. R., Kirov G., Landen M., Leboyer M., Lewis C. M., Li Q. S., Lissowska J., Lochner C., Loughland C., Martin N. G., Mathews C. A., Mayoral F., McElroy S. L., McIntosh A. M., McMahon F. J., Melle I., Michie P., Milani L., Mitchell P. B., Morken G., Mors O., Mortensen P. B., Mowry B., Muller-Myhsok B., Myers R. M., Neale B. M., Nievergelt C. M., Nordentoft M., Nothen M. M., O'Donovan M. C., Oedegaard K. J., Olsson T., Owen M. J., Paciga S. A., Pantelis C., Pato C., Pato M. T., Patrinos G. P., Perlis R. H., Posthuma D., Ramos-Quiroga J. A., Reif A., Reininghaus E. Z., Ribases M., Rietschel M., Ripke S., Rouleau G. A., Saito T., Schall U., Schalling M., Schofield P. R., Schulze T. G., Scott L. J., Scott R. J., Serretti A., Shannon Weickert C., Smoller J. W., Stefansson H., Stefansson K., Stordal E., Streit F., Sullivan P. F., Turecki G., Vaaler A. E., Vieta E., Vincent J. B., Waldman I. D., Weickert T. W., Werge T., Wray N. R., Zwart J. -A., Biernacka J. M., Nurnberger J. I., Cichon S., Edenberg H. J., Stahl E. A., McQuillin A., Di Florio A., Ophoff R. A., Andreassen O. A.
المساهمون: Mullins N., Forstner A.J., O'Connell K.S., Coombes B., Coleman J.R.I., Qiao Z., Als T.D., Bigdeli T.B., Borte S., Bryois J., Charney A.W., Drange O.K., Gandal M.J., Hagenaars S.P., Ikeda M., Kamitaki N., Kim M., Krebs K., Panagiotaropoulou G., Schilder B.M., Sloofman L.G., Steinberg S., Trubetskoy V., Winsvold B.S., Won H.-H., Abramova L., Adorjan K., Agerbo E., Al Eissa M., Albani D., Alliey-Rodriguez N., Anjorin A., Antilla V., Antoniou A., Awasthi S., Baek J.H., Baekvad-Hansen M., Bass N., Bauer M., Beins E.C., Bergen S.E., Birner A., Bocker Pedersen C., Boen E., Boks M.P., Bosch R., Brum M., Brumpton B.M., Brunkhorst-Kanaan N., Budde M., Bybjerg-Grauholm J., Byerley W., Cairns M., Casas M., Cervantes P., Clarke T.-K., Cruceanu C., Cuellar-Barboza A., Cunningham J., Curtis D., Czerski P.M., Dale A.M., Dalkner N., David F.S., Degenhardt F., Djurovic S., Dobbyn A.L., Douzenis A., Elvsashagen T., Escott-Price V., Ferrier I.N., Fiorentino A., Foroud T.M., Forty L., Frank J., Frei O., Freimer N.B., Frisen L., Gade K., Garnham J., Gelernter J., Giortz Pedersen M., Gizer I.R., Gordon S.D., Gordon-Smith K., Greenwood T.A., Grove J., Guzman-Parra J., Ha K., Haraldsson M., Hautzinger M., Heilbronner U., Hellgren D., Herms S., Hoffmann P., Holmans P.A., Huckins L., Jamain S., Johnson J.S., Kalman J.L.
سنة النشر: 2021
المجموعة: IRIS Università degli Studi di Bologna (CRIS - Current Research Information System)
مصطلحات موضوعية: Bipolar Disorder, Case-Control Studie, Chromosomes, Human, Genetic Predisposition to Disease, Genome, Major Histocompatibility Complex, Multifactorial Inheritance, Phenotype, Quantitative Trait Loci, Risk Factor, Genome-Wide Association Study
الوصف: Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies.
نوع الوثيقة: article in journal/newspaper
وصف الملف: STAMPA
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34002096; info:eu-repo/semantics/altIdentifier/wos/WOS:000651382200001; volume:53; issue:6; firstpage:817; lastpage:829; numberofpages:13; journal:NATURE GENETICS; http://hdl.handle.net/11585/851076Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85107422437
DOI: 10.1038/s41588-021-00857-4
الإتاحة: https://doi.org/10.1038/s41588-021-00857-4Test
http://hdl.handle.net/11585/851076Test
رقم الانضمام: edsbas.872AF526
قاعدة البيانات: BASE