Impact of Genetic and Nongenetic Factors on Body Mass Index and Waist-Hip Ratio Change in HIV-Infected Individuals Initiating Antiretroviral Therapy
| العنوان: | Impact of Genetic and Nongenetic Factors on Body Mass Index and Waist-Hip Ratio Change in HIV-Infected Individuals Initiating Antiretroviral Therapy |
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| المؤلفون: | Enos Bernasconi, Hansjakob Furrer, Sebastian Haubitz, Chantal Csajka, Christian Hammer, Monia Guidi, Barbara Hasse, Philip E. Tarr, Aziz Chaouch, Matthias Cavassini, Alexandra Calmy, Jacques Fellay, Thierry Buclin, Christian W. Thorball, Catalina Barceló, Alexandra U. Scherrer |
| المساهمون: | Swiss HIV Cohort Study, Anagnostopoulos, A., Battegay, M., Bernasconi, E., Böni, J., Braun, D.L., Bucher, H.C., Calmy, A., Cavassini, M., Ciuffi, A., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Furrer, H., Fux, C.A., Günthard, H.F., Haerry, D., Hasse, B., Hirsch, H.H., Hoffmann, M., Hösli, I., Huber, M., Kahlert, C.R., Kaiser, L., Keiser, O., Klimkait, T., Kouyos, R.D., Kovari, H., Ledergerber, B., Martinetti, G., Martinez de Tejada, B., Marzolini, C., Metzner, K.J., Müller, N., Nicca, D., Paioni, P., Pantaleo, G., Perreau, M., Rauch, A., Rudin, C., Scherrer, A.U., Schmid, P., Speck, R., Stöckle, M., Tarr, P., Trkola, A., Vernazza, P., Wandeler, G., Weber, R., Yerly, S., Anagnostopoulos, A, Battegay, M, Böni, J, Braun, D L, Bucher, H C, Ciuffi, A, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fux, C A, Günthard, H F, Haerry, D, Hirsch, H H, Hoffmann, M, Hösli, I, Huber, M, Kahlert, C R, Kaiser, L, Keiser, Olivia, Klimkait, T, Kouyos, R D, Kovari, H, Ledergerber, B, Martinetti, G, Martinez De Tejada Weber, Begona, Marzolini, C, Metzner, K J, Müller, N, Nicca, D, Paioni, P, Pantaleo, G, Perreau, M, Rauch, A, Rudin, C, Schmid, P, Speck, R, Stöckle, M, Trkola, A, Vernazza, P, Weber, R, Yerly Ferrillo, Sabine |
| المصدر: | Open forum infectious diseases, vol. 7, no. 1, pp. ofz464 Barceló, Catalina; Guidi, Monia; Thorball, Christian W; Hammer, Christian; Chaouch, Aziz; Scherrer, Alexandra U; Hasse, Barbara; Cavassini, Matthias; Furrer, Hansjakob; Calmy, Alexandra; Haubitz, Sebastian; Bernasconi, Enos; Buclin, Thierry; Fellay, Jacques; Tarr, Philip E; Csajka, Chantal (2020). Impact of Genetic and Nongenetic Factors on Body Mass Index and Waist-Hip Ratio Change in HIV-Infected Individuals Initiating Antiretroviral Therapy. Open Forum Infectious Diseases, 7(1), ofz464. Oxford University Press 10.1093/ofid/ofz464 <http://dx.doi.org/10.1093/ofid/ofz464Test> Open Forum Infectious Diseases Open Forum Infectious Diseases, Vol. 7, No 1 (2020) P. ofz464 |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, obesity, cardiovascular-disease, Overweight, 0302 clinical medicine, Waist–hip ratio, genetics, 030212 general & internal medicine, skin and connective tissue diseases, Body mass index, Abdominal obesity, risk, ddc:616, 2. Zero hunger, ddc:615, food and beverages, Antiretroviral therapy, 3. Good health, Infectious Diseases, Oncology, randomized controlled-trial, medicine.symptom, Nadir CD4 cell count, Cohort study, medicine.medical_specialty, Waist, weight-gain, antiretroviral therapy, united-states, 030106 microbiology, 610 Medicine & health, body mass index, metabolic syndrome, abdominal obesity, human-immunodeficiency-virus, fat changes, 03 medical and health sciences, Internal medicine, Genetics, Major Article, medicine, Obesity, business.industry, Weight change, association, nutritional and metabolic diseases, nadir cd4 cell count, Odds ratio, Waist-hip ratio, nadir CD4 cell count, waist-hip ratio, sense organs, business |
| الوصف: | Objective. There is limited data on abdominal obesity and the influence of genetics on weight change after ant iretroviral therapy (ART) initiation. We assessed body mass index (BMI) and waist hip ration (WHR) change over time in the Swiss HIV Cohort study (SHCS). Methods. Mixed-effects models characterizing BMI and WHR change over time in 1090 SHCS participants initiating ART between 2005 and 2015 were developed and used to quantify the influence of demographics, clinical factors, and genetic background. Results. Individuals with CD4 nadir = 200, and 2.8 times more WHR than individuals with >= 100 (P < .001) during the first 1.5 and 2.5 years after ART initiation, respectively. The risk of being overweight or obese after 1.5 years increased with CD4 nadir = 200 (OR, 1.69; 95% CI, 1.26-2.32), persisting after 10 years of ART. The risk of abdominal obesity after 2.5 years increased with CD4 nadir = 100 (OR, 1.35; 95% CI, 1.17-1.54 [in men]; OR, 1.36; 95% CI, 1.18-1.57 [in women]), persisting after 10 years of ART No significant differences were found across antiretroviral drug classes or genetic scores. Conclusions. The risk of general and abdominal obesity increased with CD4 nadir |
| وصف الملف: | application/pdf |
| تدمد: | 2328-8957 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eee1ebe7269ea5c9c054fa96f046343Test https://doi.org/10.1093/ofid/ofz464Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3eee1ebe7269ea5c9c054fa96f046343 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23288957 |
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