المؤلفون: Li, Gengxiao, Zhang, Zhen, Gao, Yiyuan, Zhu, Chengcheng, Zhou, Shanshan, Cao, Lizhen, Zhao, Zhiwei, Zhao, Jun, Ordovas, Karen, Lou, Mingwu, Li, Kuncheng, Pohost, Gerald M.

المصدر: Journal of Cardiovascular Magnetic Resonance (BioMed Central); 11/21/2022, Vol. 24 Issue 1, p1-15, 15p

مصطلحات موضوعية: HEART physiology, REFERENCE values, LEFT heart ventricle, LEFT ventricular dysfunction, AGE distribution, RIGHT heart ventricle, MAGNETIC resonance imaging, CARDIAC contraction, SEX distribution, RIGHT ventricular dysfunction, DESCRIPTIVE statistics, AGING, DIASTOLE (Cardiac cycle), LONGITUDINAL method

مستخلص: Background: As a noninvasive tool, myocardial deformation imaging may facilitate the early detection of cardiac dysfunction. However, normal reference ranges of myocardial strain and strain rate (SR) based on large-scale East Asian populations are still lacking. This study aimed to provide reference values of left ventricular (LV) and right ventricular (RV) strain and SR based on a large cohort of healthy Chinese adults using cardiovascular magnetic resonance (CMR) feature tracking (FT). Methods: Five hundred and sixty-six healthy Chinese adults (55.1% men) free of hypertension, diabetes, and obesity were included. On cine CMR, biventricular global radial, circumferential, and longitudinal strain (GRS, GCS, and GLS), and the peak radial, circumferential, and longitudinal systolic, and diastolic SRs (PSSRR, PSSRC, PSSRL, PDSRR, PDSRC, and PDSRL), and regional radial and circumferential strain at the basal, mid-cavity, and apical levels were measured. Associations of global and regional biventricular deformation indices with age and sex were investigated. Results: Women demonstrated greater magnitudes of LV GRS (37.6 ± 6.1% vs. 32.1 ± 5.3%), GCS (− 20.7 ± 1.9% vs. − 18.8 ± 1.9%), GLS (− 17.8 ± 1.8% vs. − 15.6 ± 1.8%), RV GRS (25.1 ± 7.8% vs. 22.1 ± 6.7%), GCS (− 14.4 ± 3.6% vs. − 13.2 ± 3.2%), GLS (− 22.4 ± 5.2% vs. − 20.2 ± 4.6%), and biventricular peak systolic and diastolic SR in all three coordinate directions (all P < 0.05). For the LV, aging was associated with increasing amplitudes of GRS, GCS, and decreasing amplitudes of PDSRR, PDSRC, PDSRL (all P < 0.05). For the RV, aging was associated with an increase in the magnitudes of GRS, GCS, GLS, PSSRR, PSSRC, PSSRL, and a decrease in the magnitude of PDSRR, PDSRC (all P < 0.05). Biventricular radial and circumferential strain measurements at the basal, mid-cavity, and apical levels were all significantly related to age and sex in both sexes (all P < 0.05). Conclusions: We provide age- and sex-specific normal values of biventricular strain and SR based on a large sample of healthy Chinese adults with a broad age range. These results may be served as a reference standard for cardiac function assessment, especially for the Chinese population. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Cardiovascular Magnetic Resonance (BioMed Central) is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Pennell, Dudley J, Sechtem, Udo P, Higgins, Charles B, Manning, Warren J, Pohost, Gerald M, Rademakers, Frank, van Rossum, Albert C, Shaw, Leslee J, Yucel, E Kent

مصطلحات موضوعية: Cardiovascular Diseases, Coronary Disease, Cost-Benefit Analysis, Europe, Heart Defects, Congenital, Heart Diseases, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, United States, Vascular Diseases

الوصف: status: published

العلاقة: Journal of Cardiovascular Magnetic Resonance vol:6 issue:4 pages:727-765; https://lirias.kuleuven.be/handle/123456789/24188Test

الإتاحة: https://lirias.kuleuven.be/handle/123456789/24188Test

المؤلفون: Doyle, Mark, Weinberg, Nicole, Pohost, Gerald M., Bairey Merz, C. Noel, Shaw, Leslee J., Sopko, George, Fuisz, Anthon, Rogers, William J., Walsh, Edward G., Johnson, B. Delia, Sharaf, Barry L., Pepine, Carl J., Mankad, Sunil, Reis, Steven E., Vido, Diane A., Rayarao, Geetha, Bittner, Vera, Tauxe, Lindsey, Olson, Marian B., Kelsey, Sheryl F.

المصدر: JACC: Cardiovascular Imaging; Oct2010, Vol. 3 Issue 10, p1030-1036, 7p

مصطلحات موضوعية: RADIOISOTOPES in cardiology, CORONARY disease, FOLLOW-up studies (Medicine), MYOCARDIAL infarction, CARDIOGRAPHIC tomography, LEFT heart ventricle, MAGNETIC resonance imaging

مستخلص: Objectives: The purpose of this study was to assess the prognostic value of global magnetic resonance (MR) myocardial perfusion imaging (MPI) in women with suspected myocardial ischemia and no obstructive (stenosis <50%) coronary artery disease (CAD). Background: The prognostic value of global MR-MPI in women without obstructive CAD remains unknown. Methods: Women (n = 100, mean age 57 ± 11 years, age range 31 to 76 years), with symptoms of myocardial ischemia and with no obstructive CAD, as assessed by coronary angiography, underwent MR-MPI and standard functional assessment. During follow-up (34 ± 16 months), time to first adverse event (death, myocardial infarction, or hospitalization for worsening anginal symptoms) was analyzed using global MPI and left ventricular ejection fraction (EF) data. Results: Adverse events occurred in 23 (23%) women. Using univariable Cox proportional hazards regression modeling, variables found to be predictive of adverse events were global MR-MPI average uptake slope (p < 0.05), the ratio of MR-MPI peak signal amplitude to uptake slope (p < 0.05), and EF (p < 0.05). Two multivariable Cox models were formed, 1 using variables that were performance site dependent: ratio of MR-MPI peak amplitude to uptake slope together with EF (chi square: 13, p < 0.005); and a model using variables that were performance site independent: MR-MPI slope and EF (chi square: 12, p < 0.005). Each of the 2 multivariable models remained predictive of adverse events after adjustment for age, disease history, and Framingham risk score. For each of the Cox models, patients were categorized as high risk if they were in the upper quartile of the model and as not high risk otherwise. Kaplan-Meier analysis of time to event was performed for high risk versus not high risk for site-dependent (log rank: 15.2, p < 0.001) and site-independent (log rank: 13.0, p < 001) models. Conclusions: Among women with suspected myocardial ischemia and no obstructive CAD, MR-MPI–determined global measurements of normalized uptake slope and peak signal uptake, together with global functional assessment of EF, appear to predict prognosis. [Copyright &y& Elsevier]

: Copyright of JACC: Cardiovascular Imaging is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Forder, John R., Pohost, Gerald M.

المصدر: Journal of Clinical Investigation. 6/1/2003, Vol. 111 Issue 11, p1630. 10p.

مصطلحات موضوعية: *NUCLEAR magnetic resonance spectroscopy, *MAGNETIC resonance imaging, *DIAGNOSTIC imaging, *SPECTRUM analysis, *NUCLEAR spectroscopy

مستخلص: Presents information on a study which analyzed nuclear magnetic resonance (NMR) spectroscopy and imaging. Techniques in NMR spectroscopy and imaging; Spectroscopic localization techniques; Discussion on chemical shift imaging; Applications of imaging for the future.

المؤلفون: Walsh, Edward G., Anayiotos, Andreas, Doyle, Mark, Pohost, Gerald M.

المصدر: Technology & Health Care; 2002, Vol. 10 Issue 1, p57-63, 7p

مصطلحات موضوعية: MAGNETIC resonance imaging, MYOCARDIAL reperfusion

مستخلص: Myocardial perfusion imaging using Gd contrast agents is typically performed with bolus injections of the contrast agent using a power injector to provide for consistent and sufficiently rapid injection rates for all patients. For protocols in which a peripheral venous injection is called for (e.g. antecubital vein) injection catheters of 18 ga are used where vessel geometry permits. In some patients, particularly women with smaller veins, 20 and 22 ga catheters are used. The effect of catheter size and pressure tubing length can result in high injection pressures that occasionally cause leakage or connector failure. The viscosity of the contrast agent also impacts injection pressure. In this study, a simulation of the injection pathway was constructed with time resolved pressures measured at two points in the pathway. Pressure drops were calculated for a typical MR perfusion injection protocol. [ABSTRACT FROM AUTHOR]

: Copyright of Technology & Health Care is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Dell'Italia, Louis J, Blackwell, Gerald G, Urthaler, Ferdinand, Pearce, Douglas J, Pohost, Gerald M

المصدر: Cardiovascular Research; Jun1993, Vol. 27 Issue 6, p974-979, 6p

مستخلص: Objective: Numerous models of acute and chronic left ventricular dysfunction have been used over the years. However, few can produce a rapid onset of global systolic and diastolic dysfunction that is stable and potentially reversible. The aim of this study was to develop such a model. Methods: A model of left ventricular dysfunction was produced in six intact dogs using 1% halothane anaesthesia and pharmacological autonomic blockade with atropine (0.1 mg·kg−1) and propranolol (2 mg·kg−1). Left ventricular function was assessed by combined high fidelity pressure and cinemagnetic resonance imaging (cine-MR) during increases in afterload using infusions of angiotensin. Results: Left ventricular systolic dysfunction was characterised by a diminished resting ejection fraction of 45(SD 4)% and a depressed +dP/dtmax of 1537(100) mm Hg·s−1. Diastolic dysfunction was manifested by an increased left ventricular end diastolic pressure of 16(2) mm Hg, a decreased −dP/dtmax of −1705(369) mm Hg·s−1, and a prolonged time constant of left ventricular relaxation of 42(9) ms. As left ventricular systolic pressure steadily rose with angiotensin infusion from 87(7) to 124(13) to 152(10) mm Hg (p<0.001), left ventricular ejection fraction decreased markedly from 45(4) to 35(4) to 27(4)% (p<0.001). Left ventricular +dP/dtmax did not change [1537(100) to 1500(110) to 1498(84) mm Hg·s−1] in spite of a significant increase in left ventricular end diastolic pressure from 16(2) to 21(5) to 29(7) mm Hg (p<0.001) and left ventricular end diastolic volume from 59(12) to 71(14) to 78(17) ml (p<0.001). Individual slopes of the end systolic pressure- volume relationship were also low, ranging between 2.1 and 4.4 mm Hg·s−1 (r=0.99 to 1.00), typical of impaired contractility. Conclusions: Halothane anaesthesia in dogs pretreated with large amounts of propranolol and appropriate muscarinic cholinergic blockade produces a moderate decrease in baseline systolic and diastolic function in our intact dog model. However, left ventricular systolic function showed limited contractile reserve when challenged by physiological increases in systemic arterial pressure. Impaired systolic and diastolic function may, at least in part, be related to diminished activator calcium produced by halothane in addition to the well known negative inotropic action of β adrenergic blockade.Cardiovascular Research 1993;27:974-979 [ABSTRACT FROM PUBLISHER]

: Copyright of Cardiovascular Research is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Hundley, W. Gregory, Bluemke, David A., Finn, J. Paul, Flamm, Scott D., Fogel, Mark A., Friedrich, Matthias G., Ho, Vincent B., Jerosch-Herold, Michael, Kramer, Christopher M., Manning, Warren J., Patel, Manesh, Pohost, Gerald M., Stillman, Arthur E., White, Richard D., Woodard, Pamela K.

المصدر: Journal of the American College of Cardiology. (23):2614-2662

مصطلحات موضوعية: ACCF/AHA Expert Consensus Document, safety, cardiovascular magnetic resonance, cardiovascular disease, magnetic resonance imaging

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ae4556c2f2f80952163052ab43da49a7Test

المؤلفون: Liu, Chia-Ying^1,2,3 cliu25@wisc.edu, Varadarajan, Padmini^4,5, Pohost, Gerald M.^1,4,6, Nayak, Krishna S.^1,4

المصدر: Magnetic Resonance Imaging (0730725X). Jun2008, Vol. 26 Issue 5, p661-666. 6p.

مصطلحات موضوعية: *MAGNETIC resonance imaging, *MEDICAL imaging systems, *EXCITATION (Physiology), *CAROTID artery

مستخلص: Abstract: The purpose of this study was to demonstrate and evaluate the performance of real-time color-flow MRI at 3 T using variable-density spiral (VDS) phase contrast. Spiral phase contrast imaging was implemented within a flexible real-time interactive MRI system that provided continuous image reconstruction and an intuitive user interface. The pulse sequence consisted of a spectral–spatial excitation, bipolar gradient, spiral readout and gradient spoiler. VDSs were utilized to increase spatial and/or temporal resolution relative to uniform-density spirals (UDSs). Parameter choices were guided by specific applications. Sliding window reconstruction was used to achieve a maximum display rate of 40 frames/s. No breath-holding or gating was used. Our results demonstrated that real-time color-flow movies using UDS and VDS provided adequate visualization of intracardiac flow, carotid flow and proximal coronary flow in healthy volunteers. Average aortic outflow velocity measured at the aortic valve plane using VDS was 29.4% higher than that using UDS. Peak velocity measured in the common carotid artery using VDS was 9.8% higher than that using UDS. [Copyright &y& Elsevier]

المؤلفون: Hundley, W. Gregory, Bluemke, David A., Finn, J. Paul, Flamm, Scott D., Fogel, Mark A., Friedrich, Matthias G., Ho, Vincent B., Jerosch-Herold, Michael, Kramer, Christopher M., Manning, Warren J., Patel, Manesh, Pohost, Gerald M., Stillman, Arthur E., White, Richard D., Woodard, Pamela K.

المصدر: Journal of the American College of Cardiology (JACC). Jun2010, Vol. 55 Issue 23, p2614-2662. 49p.