التفاصيل البيبلوغرافية
| العنوان: |
Toward an optimal cadaveric brain model for neurosurgical education: assessment of preservation, parenchyma, vascular injection, and imaging. |
| المؤلفون: |
Mignucci-Jiménez, Giancarlo1 (AUTHOR), Xu, Yuan1 (AUTHOR), On, Thomas J.1 (AUTHOR), Abramov, Irakliy1 (AUTHOR), Houlihan, Lena Mary1 (AUTHOR), Rahmani, Redi1 (AUTHOR), Koskay, Grant1 (AUTHOR), Hanalioglu, Sahin1 (AUTHOR), Meybodi, Ali Tayebi1 (AUTHOR), Lawton, Michael T.1,2 (AUTHOR), Preul, Mark C.1 (AUTHOR) Neuropub@barrowneuro.org |
| المصدر: |
Neurosurgical Review. 4/25/2024, Vol. 47 Issue 1, p1-21. 21p. |
| مصطلحات موضوعية: |
*MAGNETIC resonance imaging, *ASSESSMENT of education, *NEEDLE sharing |
| مستخلص: |
Objective: We assessed types of cadaveric head and brain tissue specimen preparations that are used in a high throughput neurosurgical research laboratory to determine optimal preparation methods for neurosurgical anatomical research, education, and training. Methods: Cadaveric specimens (N = 112) prepared using different preservation and vascular injection methods were imaged, dissected, and graded by 11 neurosurgeons using a 21-point scale. We assessed the quality of tissue and preservation in both the anterior and posterior circulations. Tissue quality was evaluated using a 9-point magnetic resonance imaging (MRI) scale. Results: Formalin-fixed specimens yielded the highest scores for assessment (mean ± SD [17.0 ± 2.8]) vs. formalin-flushed (17.0 ± 3.6) and MRI (6.9 ± 2.0). Cadaver assessment and MRI scores were positively correlated (P < 0.001, R2 0.60). Analysis showed significant associations between cadaver assessment scores and specific variables: nonformalin fixation (β = −3.3), preservation within ≤72 h of death (β = 1.8), and MRI quality score (β = 0.7). Formalin-fixed specimens exhibited greater hardness than formalin-flushed and nonformalin-fixed specimens (P ≤ 0.006). Neurosurgeons preferred formalin-flushed specimens injected with colored latex. Conclusion: For better-quality specimens for neurosurgical education and training, formalin preservation within ≤72 h of death was preferable, as was injection with colored latex. Formalin-flushed specimens more closely resembled live brain parenchyma. Assessment scores were lower for preparation techniques performed > 72 h postmortem and for nonformalin preservation solutions. The positive correlation between cadaver assessment scores and our novel MRI score indicates that donation organizations and institutional buyers should incorporate MRI as a screening tool for the selection of high-quality specimens. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
