Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge
| العنوان: | Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge |
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| المؤلفون: | Michael Pavlides, Peter Jezzard, Masliza Mahmod, Charalambos Antoniades, H Lamlum, Matthew J. Rowland, Stefan K. Piechnik, Fergus V. Gleeson, Frederik J Lange, Mayooran Shanmuganathan, Cheng Xie, Thomas W. Okell, Paul Klenerman, Mark Philip Cassar, Rebecca J. Mills, Chaoyue Wang, Nick P. Talbot, Kathryn J Saunders, David A. Holdsworth, Eric O Ohuma, Nicola Filippini, Ferenc E. Mózes, Karla L. Miller, Ivan Koychev, Ludovica Griffanti, McConnell Fak., Najib M. Rahman, Vanessa M Ferreira, Mark Jenkinson, Ho L-P., Christoph Arthofer, Stephen M. Smith, Stefan Neubauer, Elizabeth M. Tunnicliffe, Clare E. Mackay, M J Woodman, C Krasopoulos, Paul Harrison, Keith M. Channon, Fidel Alfaro-Almagro, Nayia Petousi, Fintan Sheerin, Christopher E. Brightling, Betty Raman, Adam J. Lewandowski, Kyle T.S. Pattinson, Jesper L. R. Andersson, John R. Geddes, Brian Angus |
| المصدر: | EClinicalMedicine, Vol 31, Iss, Pp 100683-(2021) EClinicalMedicine |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Spirometry, medicine.medical_specialty, Research paper, Exercise intolerance, Disease, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Internal medicine, medicine, 030212 general & internal medicine, Effects of sleep deprivation on cognitive performance, Post-hospital discharge, Survivors, 0101 mathematics, Depression (differential diagnoses), lcsh:R5-920, medicine.diagnostic_test, business.industry, SARS-CoV-2 infection, 010102 general mathematics, VO2 max, COVID-19, General Medicine, Follow up, Medium term, Magnetic Resonance Imaging, Multiorgan effects, Coronavirus, Mental health, medicine.symptom, business, lcsh:Medicine (General), Body mass index |
| الوصف: | Background The medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality of life and mental health are poorly understood. Methods Fifty-eight COVID-19 patients post-hospital discharge and 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver and kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary exercise test (CPET), quality of life, cognitive and mental health assessments. Findings At 2–3 months from disease-onset, 64% of patients experienced breathlessness and 55% reported fatigue. On MRI, abnormalities were seen in lungs (60%), heart (26%), liver (10%) and kidneys (29%). Patients exhibited changes in the thalamus, posterior thalamic radiations and sagittal stratum on brain MRI and demonstrated impaired cognitive performance, specifically in the executive and visuospatial domains. Exercise tolerance (maximal oxygen consumption and ventilatory efficiency on CPET) and six-minute walk distance were significantly reduced. The extent of extra-pulmonary MRI abnormalities and exercise intolerance correlated with serum markers of inflammation and acute illness severity. Patients had a higher burden of self-reported symptoms of depression and experienced significant impairment in all domains of quality of life compared to controls (p Interpretation A significant proportion of patients discharged from hospital reported symptoms of breathlessness, fatigue, depression and had limited exercise capacity. Persistent lung and extra-pulmonary organ MRI findings are common in patients and linked to inflammation and severity of acute illness. Funding NIHR Oxford and Oxford Health Biomedical Research Centres, British Heart Foundation Centre for Research Excellence, UKRI, Wellcome Trust, British Heart Foundation. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2589-5370 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13acfeb74e7da32af46fd8d5efd2023aTest http://www.sciencedirect.com/science/article/pii/S2589537020304272Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....13acfeb74e7da32af46fd8d5efd2023a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25895370 |
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