المؤلفون: Jaarsma-Coes, M.G., Ghaznawi, R., Hendrikse, J., Slump, C., Witkamp, T.D., Graaf, Y. van der, Geerlings, M.I., Bresser, J. de, Algra, A., Grobbee, D.E., Rutten, G.E.H.M., Visseren, F.L.J., Borst, G.J. de, Kappelle, L.J., Leiner, T., Doevendans, P.A., Second Manifestn ARTerial Dis SMAR

المصدر: Journal of Cerebral Blood Flow and Metabolism

مصطلحات موضوعية: Brain imaging, cluster analysis, magnetic resonance imaging, atherosclerosis, patient outcome

الوصف: Neurodegenerative and neurovascular diseases lead to heterogeneous brain abnormalities. A combined analysis of these abnormalities by phenotypes of the brain might give a more accurate representation of the underlying aetiology. We aimed to identify different MRI phenotypes of the brain and assessed the risk of future stroke and mortality within these subgroups. In 1003 patients (59 +/- 10 years) from the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study, different quantitative 1.5T brain MRI markers were used in a hierarchical clustering analysis to identify 11 distinct subgroups with a different distribution in brain MRI markers and cardiovascular risk factors, and a different risk of stroke (Cox regression: from no increased risk compared to the reference group with relatively few brain abnormalities to HR = 10.34; 95% CI 3.80 <-> 28.12 for the multi-burden subgroup) and mortality (from no increased risk compared to the reference group to HR = 4.00; 95% CI 2.50 <-> 6.40 for the multi-burden subgroup). In conclusion, within a group of patients with manifest arterial disease, we showed that different MRI phenotypes of the brain can be identified and that these were associated with different risks of future stroke and mortality. These MRI phenotypes can possibly classify individual patients and assess their risk of future stroke and mortality. ; Ophthalmic research

وصف الملف: application/pdf

العلاقة: lumc-id: 111527937; https://hdl.handle.net/1887/3184071Test

الإتاحة: https://doi.org/10.1177/0271678X18818918Test
https://hdl.handle.net/1887/3184071Test

المؤلفون: Ghaznawi, R., Geerlings, M.I., Jaarsma-Coes, M.G., Zwartbol, M.H.T., Kuijf, H.J., Graaf, Y. van der, Witkamp, T.D., Hendrikse, J., Bresser, J. de, Petersen, R. van, Dinther, B.G.F., Algra, A., Grobbee, D.E., Rutten, G.E.H.M., Visseren, F.L.J., Borst, G.J. de, Kappelle, L.J., Leiner, T., Doevendans, P.A., SMART Study Grp

المصدر: Journal of Cerebral Blood Flow and Metabolism

مصطلحات موضوعية: Small vessel disease, lacunes, white matter hyperintensities, magnetic resonance imaging, cerebrovascular disease

الوصف: Lacunes and white matter hyperintensities (WMHs) are features of cerebral small vessel disease (CSVD) that are associated with poor functional outcomes. However, how the two are related remains unclear. In this study, we examined the association between lacunes and several WMH features in patients with a history of vascular disease. A total of 999 patients (mean age 59 +/- 10 years) with a 1.5 T brain magnetic resonance imaging (MRI) scan were included from the SMART-MR study. Lacunes were scored visually and WMH features (volume, subtype and shape) were automatically determined. Analyses consisted of linear and Poisson regression adjusted for age, sex, and total intracranial volume (ICV). Patients with lacunes (n = 188; 19%) had greater total (B = 1.03, 95% CI: 0.86 to 1.21), periventricular/confluent (B = 1.08, 95% CI: 0.89 to 1.27), and deep (B = 0.71, 95% CI: 0.44 to 0.97) natural log-transformed WMH volumes than patients without lacunes. Patients with lacunes had an increased risk of confluent type WMHs (RR = 2.41, 95% CI: 1.98 to 2.92) and deep WMHs (RR = 1.41, 95% CI: 1.22 to 1.62) and had a more irregular shape of confluent WMHs than patients without lacunes, independent of total WMH volume. In conclusion, we found that lacunes on MRI were associated with WMH features that correspond to more severe small vessel changes, mortality, and poor functional outcomes. ; Neuro Imaging Research

العلاقة: lumc-id: 81102666; https://hdl.handle.net/1887/121574Test

الإتاحة: https://doi.org/10.1177/0271678X18800463Test
https://hdl.handle.net/1887/121574Test

المؤلفون: Jaarsma-Coes, M.G., Ghaznawi, R., Hendrikse, J., Slump, C., Witkamp, T.D., Graaf, Y. van der, Geerlings, M.I., Bresser, J. de, Algra, A., Grobbee, D.E., Rutten, G.E.H.M., Visseren, F.L.J., Borst, G.J. de, Kappelle, L.J., Leiner, T., Doevendans, P.A., Second Manifestn ARTerial Dis SMAR

المصدر: Journal of Cerebral Blood Flow & Metabolism
Journal of Cerebral Blood Flow and Metabolism, 40(2), 354-364. Nature Publishing Group
Journal of Cerebral Blood Flow and Metabolism, 40(2), 354-364. SAGE PUBLICATIONS INC
Journal of Cerebral Blood Flow and Metabolism, 40(2), 354. Nature Publishing Group

مصطلحات موضوعية: Male, medicine.medical_specialty, Arterial disease, Clinical Neurology, Brain imaging, 03 medical and health sciences, 0302 clinical medicine, Neuroimaging, Risk Factors, Internal medicine, medicine, Journal Article, Humans, In patient, Prospective Studies, Mortality, Stroke, Aged, medicine.diagnostic_test, business.industry, Brain, Magnetic resonance imaging, Cerebral Infarction, Original Articles, Middle Aged, medicine.disease, Neurovascular bundle, Phenotype, Magnetic Resonance Imaging, Neurology, Patient outcomes, Cardiology, Female, Neurology (clinical), atherosclerosis, business, Cardiology and Cardiovascular Medicine, 030217 neurology & neurosurgery, patient outcome, cluster analysis

الوصف: Neurodegenerative and neurovascular diseases lead to heterogeneous brain abnormalities. A combined analysis of these abnormalities by phenotypes of the brain might give a more accurate representation of the underlying aetiology. We aimed to identify different MRI phenotypes of the brain and assessed the risk of future stroke and mortality within these subgroups. In 1003 patients (59 ± 10 years) from the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study, different quantitative 1.5T brain MRI markers were used in a hierarchical clustering analysis to identify 11 distinct subgroups with a different distribution in brain MRI markers and cardiovascular risk factors, and a different risk of stroke (Cox regression: from no increased risk compared to the reference group with relatively few brain abnormalities to HR = 10.34; 95% CI 3.80↔28.12 for the multi-burden subgroup) and mortality (from no increased risk compared to the reference group to HR = 4.00; 95% CI 2.50↔6.40 for the multi-burden subgroup). In conclusion, within a group of patients with manifest arterial disease, we showed that different MRI phenotypes of the brain can be identified and that these were associated with different risks of future stroke and mortality. These MRI phenotypes can possibly classify individual patients and assess their risk of future stroke and mortality.

وصف الملف: application/pdf; text/plain

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09e3f66294168398df1879f95cbaef9Test
https://pubmed.ncbi.nlm.nih.gov/30547694Test

المؤلفون: Ghaznawi, R., Geerlings, M.I., Jaarsma-Coes, M.G., Zwartbol, M.H.T., Kuijf, H.J., Graaf, Y. van der, Witkamp, T.D., Hendrikse, J., Bresser, J. de, Petersen, R. van, Dinther, B.G.F., Algra, A., Grobbee, D.E., Rutten, G.E.H.M., Visseren, F.L.J., Borst, G.J. de, Kappelle, L.J., Leiner, T., Doevendans, P.A., SMART Study Grp

المصدر: Journal of Cerebral Blood Flow & Metabolism
Journal of Cerebral Blood Flow and Metabolism, 39(12), 2486. Nature Publishing Group
Journal of Cerebral Blood Flow and Metabolism, 39(12), 2486-2496. SAGE PUBLICATIONS INC
Journal of Cerebral Blood Flow and Metabolism, 39(12), 2486-2496

مصطلحات موضوعية: Male, medicine.medical_specialty, Neurology, Clinical Neurology, lacunes, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Internal medicine, medicine, Humans, In patient, Poisson regression, Aged, medicine.diagnostic_test, business.industry, Vascular disease, Leukoaraiosis, Magnetic resonance imaging, Original Articles, Middle Aged, white matter hyperintensities, medicine.disease, Magnetic Resonance Imaging, White Matter, Hyperintensity, Small vessel disease, cerebrovascular disease, Increased risk, White matter hyperintensity, Cerebral Small Vessel Diseases, symbols, Cardiology, Female, Neurology (clinical), business, Cardiology and Cardiovascular Medicine, 030217 neurology & neurosurgery

الوصف: Lacunes and white matter hyperintensities (WMHs) are features of cerebral small vessel disease (CSVD) that are associated with poor functional outcomes. However, how the two are related remains unclear. In this study, we examined the association between lacunes and several WMH features in patients with a history of vascular disease. A total of 999 patients (mean age 59 ± 10 years) with a 1.5 T brain magnetic resonance imaging (MRI) scan were included from the SMART-MR study. Lacunes were scored visually and WMH features (volume, subtype and shape) were automatically determined. Analyses consisted of linear and Poisson regression adjusted for age, sex, and total intracranial volume (ICV). Patients with lacunes (n = 188; 19%) had greater total (B = 1.03, 95% CI: 0.86 to 1.21), periventricular/confluent (B = 1.08, 95% CI: 0.89 to 1.27), and deep (B = 0.71, 95% CI: 0.44 to 0.97) natural log-transformed WMH volumes than patients without lacunes. Patients with lacunes had an increased risk of confluent type WMHs (RR = 2.41, 95% CI: 1.98 to 2.92) and deep WMHs (RR = 1.41, 95% CI: 1.22 to 1.62) and had a more irregular shape of confluent WMHs than patients without lacunes, independent of total WMH volume. In conclusion, we found that lacunes on MRI were associated with WMH features that correspond to more severe small vessel changes, mortality, and poor functional outcomes.

وصف الملف: image/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b6c9ce09e24cb6ba1f46f7572803bbTest
https://pubmed.ncbi.nlm.nih.gov/30204039Test

المؤلفون: Veen, P.H. van der, Muller, M., Vincken, K.L., Hendrikse, J., Mali, W.P.T.M., Graaf, Y. van der, Geerlings, M.I., SMART Study Grp

المساهمون: Internal medicine, ICaR - Circulation and metabolism

المصدر: Stroke, 46(5), 1233-1238
van der Veen, P H, Muller, M, Vincken, K L, Hendrikse, J, Mali, W P, van der Graaf, Y & Geerlings, M I 2015, ' Longitudinal Relationship Between Cerebral Small-Vessel Disease and Cerebral Blood Flow The Second Manifestations of Arterial Disease-Magnetic Resonance Study ', Stroke, vol. 46, no. 5, pp. 1233-1238 . https://doi.org/10.1161/STROKEAHA.114.008030Test
Stroke, 46(5), 1233-1238. Lippincott Williams and Wilkins
Stroke, 46(5), 1233. Lippincott Williams and Wilkins

مصطلحات موضوعية: Male, Pathology, Arterial disease, Disease, AMYLOID ANGIOPATHY, Cohort Studies, Risk Factors, SMART-MR, PERFUSION, WHITE-MATTER HYPERINTENSITIES, magnetic resonance imaging, Longitudinal Studies, Prospective Studies, BRAIN, medicine.diagnostic_test, cerebral small vessel disease, OXYGEN-METABOLISM, Age Factors, CEREBROVASCULAR REACTIVITY, Middle Aged, White Matter, Cerebral blood flow, Cerebrovascular Circulation, Brain size, Cardiology, Female, Cerebral Arterial Diseases, Cardiology and Cardiovascular Medicine, Perfusion, medicine.medical_specialty, CIRCULATION, COGNITIVE PERFORMANCE, Sex Factors, Internal medicine, Journal Article, medicine, Humans, Aged, Advanced and Specialized Nursing, LESIONS, business.industry, Magnetic resonance imaging, Hyperintensity, Cerebral Small Vessel Diseases, Stroke, Lacunar, Neurology (clinical), Small vessel, atherosclerosis, business, Follow-Up Studies

الوصف: Background and Purpose— Cerebral small-vessel disease and cerebral blood flow (CBF) are interrelated. However, the direction of the relationship is unknown, and longitudinal studies are scarce. We investigated the longitudinal relationship between CBF and white matter hyperintensities (WMHs) and lacunes, as representatives of cerebral small-vessel disease, in patients with manifest arterial disease. Methods— Within the Second Manifestations of Arterial Disease-Magnetic Resonance (SMART-MR) study, 1.5T brain magnetic resonance imaging, including an MR angiography, was obtained at baseline and after on ≈3.9 years of follow-up in 575 patients with manifest arterial disease (mean age, 57±10 years). Longitudinal associations of WMHs and lacunes with parenchymal CBF (pCBF; per 100-mL brain volume) were estimated using regression analyses, adjusted for age, sex, follow-up time, and baseline brain measures. Results— Baseline pCBF was not associated with progression of WMHs and lacunes over time. However, periventricular and deep WMHs at baseline were associated with decline in pCBF; mean (95% confidence interval) decline in pCBF per % intracranial volume increase in periventricular and deep WMH volume was −0.70 (−1.40 to −0.00) and −1.01 (−1.64 to −0.38) mL/min per 100-mL brain volume, respectively. These associations were partly explained by cardiovascular risk factors but remained significant for deep WMHs (mean decline [95% confidence interval] in pCBF per % intracranial volume increase in deep WMH volume was −0.92 [−1.56 to −0.28] mL/min per 100-mL brain volume). Lacunes were not associated with change in pCBF. Conclusions— In patients with manifest arterial disease, baseline periventricular and deep WMH volumes were associated with decline in pCBF over time, but baseline pCBF was not associated with progression of WMHs and lacunes over time.

وصف الملف: image/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c83ccb4b2f4aba9d72c3a8e56cd9b6bTest
https://doi.org/10.1161/strokeaha.114.008030Test

المؤلفون: Tiehuis, A.M., Graaf, Y. van der, Mali, W.P.T.M., Vincken, K., Muller, M., Geerlings, M.I., SMART Study Grp

المساهمون: Internal medicine, ACS - Atherosclerosis & ischemic syndromes

المصدر: Diabetes Care, 37(9), 2515-2521
Tiehuis, A M, Van Der Graaf, Y, Mali, W P T M, Vincken, K, Muller, M & Geerlings, M I 2014, ' Metabolic syndrome, prediabetes, and brain abnormalities onmri in patients with manifest arterial disease : The smart-mr study ', Diabetes Care, vol. 37, no. 9, pp. 2515-2521 . https://doi.org/10.2337/dc14-0154Test
Diabetes Care, 37(9), 2515-2521. American Diabetes Association Inc.

مصطلحات موضوعية: Male, medicine.medical_specialty, Aging, Endocrinology, Diabetes and Metabolism, Coronary Artery Disease, Prediabetic State, Peripheral Arterial Disease, Risk Factors, Diabetes mellitus, Internal medicine, Internal Medicine, Medicine, Humans, Prediabetes, Prospective Studies, Abdominal obesity, Advanced and Specialized Nursing, Metabolic Syndrome, Brain Diseases, business.industry, Hypertriglyceridemia, Middle Aged, medicine.disease, Obesity, Magnetic Resonance Imaging, Hyperintensity, Endocrinology, Cross-Sectional Studies, Brain size, Cardiology, Disease Progression, Female, Cerebral Arterial Diseases, Metabolic syndrome, medicine.symptom, business

الوصف: OBJECTIVE Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors leading to atherosclerosis and diabetes. Diabetes is associated with both structural and functional abnormalities of the brain. MetS, even before diabetes is diagnosed, may also predispose to cerebral changes, probably through shared mechanisms. We examined the association of MetS with cerebral changes in patients with manifest arterial disease. RESEARCH DESIGN AND METHODS Cross-sectional data on MetS and brain MRI were available in 1,232 participants with manifest arterial disease (age 58.6 ± 10.1 years; 37% MetS). Volumes of brain tissue, ventricles, and white matter hyperintensities (WMH) were obtained by automated segmentation and expressed relative to intracranial volume. Infarcts were distinguished into lacunar and nonlacunar infarcts. RESULTS The presence of MetS (n = 451) was associated with smaller brain tissue volume (B −0.72% [95% CI −0.97, −0.47]), even in the subgroup of patients without diabetes (B −0.42% [95% CI −0.71, −0.13]). MetS was not associated with an increased occurrence of WMH or cerebral infarcts. Impaired glucose metabolism, abdominal obesity, and elevated triglycerides were individual components associated with smaller brain volume. Obesity and hypertriglyceridemia remained associated with smaller brain volume when patients with diabetes were excluded. Hypertension was associated with an increased occurrence of WMH and infarcts. CONCLUSIONS In patients with manifest arterial disease, presence of MetS is associated with smaller brain volume, even in patients without diabetes. Screening for MetS and treatment of its individual components, in particular, hyperglycemia, hypertriglyceridemia, and obesity, may prevent progression of cognitive aging in patients with MetS, even in a prediabetic stage.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e52e6d1db3fb6b023794ec50e40e50Test
http://www.scopus.com/inward/record.url?scp=84906701270&partnerID=8YFLogxKTest

المؤلفون: Veen, P.H. van der, Muller, M., Vincken, K.L., Mali, W.P.T.M., Graaf, Y. van der, Geerlings, M.I., SMART Study Grp

المساهمون: Internal medicine, NCA - neurodegeneration

المصدر: Neurobiology of Aging, 35(7), 1624-1631. Elsevier Inc.
Neurobiology of Aging, 35(7), 1624-1631
van der Veen, P H, Muller, M, Vincken, K L, Mali, W P T M, van der Graaf, Y & Geerlings, M I 2014, ' Brain volumes and risk of cardiovascular events and mortality. The SMART-MR study ', Neurobiology of Aging, vol. 35, no. 7, pp. 1624-1631 . https://doi.org/10.1016/j.neurobiolaging.2014.02.003Test

مصطلحات موضوعية: Male, Risk, Aging, medicine.medical_specialty, Time Factors, Epidemiology, Population, Brain imaging, Cohort Studies, Cardiovascular events, Cerebrospinal fluid, Atrophy, Risk Factors, Cause of Death, Internal medicine, medicine, Humans, Dementia, Brain segmentation, Mortality, Cognitive decline, education, education.field_of_study, business.industry, General Neuroscience, Hazard ratio, Cohort, Brain, Organ Size, Prognosis, Atherosclerosis, medicine.disease, Magnetic Resonance Imaging, Surgery, Stroke, Cardiovascular Diseases, Brain size, Cardiology, Female, Neurology (clinical), Geriatrics and Gerontology, business, Follow-Up Studies, Developmental Biology

الوصف: Brain atrophy is a strong predictor for cognitive decline and dementia, and these are, in turn, associated with increased mortality in the general population. Patients with cardiovascular disease have more brain atrophy and a higher morbidity and mortality. We investigated if brain volumes on magnetic resonance imaging were associated with the risk of cardiovascular events and mortality in patients with manifest arterial disease (n = 1215; mean age 58 years). Automated brain segmentation was used to quantify intracranial volume, and volumes of total brain, sulcal cerebrospinal fluid, and ventricles. After a median follow-up of 8.3 years, 184 patients died, 49 patients had an ischemic stroke, and 100 patients had an ischemic cardiac complication. Smaller relative brain volumes increased the risk of all-cause death (hazard ratio [HR] per standard deviation decrease in total brain volume: 1.58, 95% confidence interval [95% CI]: 1.33-1.88), vascular death (HR 1.69, 95% CI: 1.35-2.13), and ischemic stroke (HR 1.96, 95% CI: 1.43-2.69), independent of cardiovascular risk factors. These results suggest that brain volumes are an important determinant of poor outcome in patients with high cardiovascular risk.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952ee0fcf1503c57745614cb7054117dTest
https://doi.org/10.1016/j.neurobiolaging.2014.02.003Test

المؤلفون: Geurts, Marjolein, Scheijmans, Féline E.V., van Seeters, Tom, Biessels, Geert Jan, Kappelle, L. Jaap, Velthuis, Birgitta K., van der Worp, H. Bart, Majoie, C.B., Roos, Y.B., Duijm, L.E., Keizer, K., van der Lugt, A., Dippel, D.W., Greve, Droogh de, Bienfait, H.P., van Walderveen, Marianne A. A., Wermer, M.J., Lycklama à Nijeholt, G. J., Boiten, J., Duyndam, D.A., Kwa, V.I.H., Meijer, Frederick J. A., van Dijk, E. J., Kesselring, F.O., Hofmeijer, J., Vos, J. A., Schonewille, Wouter J., van Rooij, W.J.J., de Kort, P.L., Pleiter, C. Constantijn, Bakker, S. L., Bot, J., Visser, M. C., van der Schaaf, Irene C., Dankbaar, J.W., Mali, W.P., van Seeters, T., Horsch, Alexander D., Niesten, Joris M., Biessels, G.J., Luitse, M.J., van der Graaf, Y.

المساهمون: Radiology and Nuclear Medicine, ANS - Neurovascular Disorders, ACS - Microcirculation, Neurology, ACS - Atherosclerosis & ischemic syndromes, Public and occupational health, Molecular cell biology and Immunology, Radiology and nuclear medicine, Pathology

المصدر: BMC neurology, 16(1):233. BioMed Central
Geurts, M, Scheijmans, F E V, van Seeters, T, Biessels, G J, Kappelle, L J, Velthuis, B K, van der Worp, H B, Majoie, C B, Roos, Y B, Duijm, L E, Keizer, K, van der Lugt, A, Dippel, D W, Greve, D D, Bienfait, H P, van Walderveen, M A A, Wermer, M J, Lycklama à Nijeholt, G J, Boiten, J, Duyndam, D A, Kwa, V I H, Meijer, F J A, van Dijk, E J, Kesselring, F O, Hofmeijer, J, Vos, J A, Schonewille, W J, van Rooij, W J J, de Kort, P L, Pleiter, C C, Bakker, S L, Bot, J, Visser, M C, Velthuis, B K, van der Schaaf, I C, Dankbaar, J W, Mali, W P, van Seeters, T, Horsch, A D, Niesten, J M, Biessels, G J, Kappelle, L J, Luitse, M J, van der Graaf, Y & on behalf of the DUST investigators 2016, ' Temporal profile of body temperature in acute ischemic stroke : Relation to infarct size and outcome ', BMC Neurology, vol. 16, no. 1, 233 . https://doi.org/10.1186/s12883-016-0760-7Test
BMC Neurology, 16. BioMed Central
BMC Neurology, 16(1):233. BioMed Central
BMC Neurology

مصطلحات موضوعية: Male, medicine.medical_specialty, Time Factors, Neurology, Clinical Neurology, Hypothermia, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Hypothermia, Induced, Modified Rankin Scale, Journal Article, medicine, Humans, Body temperature, cardiovascular diseases, Stroke, Aged, medicine.diagnostic_test, business.industry, Cerebral infarction, Magnetic resonance imaging, Recovery of Function, General Medicine, Prognosis, medicine.disease, Magnetic Resonance Imaging, Confidence interval, Relative risk, Anesthesia, Female, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, Research Article

الوصف: Background: High body temperatures after ischemic stroke have been associated with larger infarct size, but the temporal profile of this relation is unknown. We assess the relation between temporal profile of body temperature and infarct size and functional outcome in patients with acute ischemic stroke. Methods: In 419 patients with acute ischemic stroke we assessed the relation between body temperature on admission and during the first 3 days with both infarct size and functional outcome. Infarct size was measured in milliliters on CT or MRI after 3 days. Poor functional outcome was defined as a modified Rankin Scale score ≥3 at 3 months. Results: Body temperature on admission was not associated with infarct size or poor outcome in adjusted analyses. By contrast, each additional 1.0 °C in body temperature on day 1 was associated with 0.31 ml larger infarct size (95% confidence interval (CI) 0.04-0.59), on day 2 with 1.13 ml larger infarct size(95% CI, 0.83-1.43), and on day 3 with 0.80 ml larger infarct size (95% CI, 0.48-1.12), in adjusted linear regression analyses. Higher peak body temperatures on days two and three were also associated with poor outcome (adjusted relative risks per additional 1.0 °C in body temperature, 1.52 (95% CI, 1.17-1.99) and 1.47 (95% CI, 1.22-1.77), respectively). Conclusions: Higher peak body temperatures during the first days after ischemic stroke, rather than on admission, are associated with larger infarct size and poor functional outcome. This suggests that prevention of high temperatures may improve outcome if continued for at least 3 days.

وصف الملف: image/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3ed68cf4b1290fd1ce7c95c559b1b5Test
https://pure.amc.nl/en/publications/temporal-profile-of-body-temperature-in-acute-ischemic-strokeTest(18efa5b7-6300-4e21-a10d-f141e8f546da).html

المؤلفون: Buddeke, J., Kooistra, M., Zuithoff, N.P.A., Gerritsen, L., Biessels, G.J., van der Graaf, Y., Geerlings, M.I., Petersen, R., Dinther, B.G.F., Algra, A., Doevendans, Pieter A, Grobbee, Diederick E, Rutten, G.E.H.M., Kappelle, L. Jaap, Leiner, T., Moll, F.L., Visseren, Frank L J

المصدر: Acta Psychiatrica Scandinavica, 135(1), 78. Blackwell Publishing Ltd
Acta Psychiatrica Scandinavica, 135(1), 78. Wiley-Blackwell

مصطلحات موضوعية: Male, hippocampus, Hippocampal formation, Hippocampus, 0302 clinical medicine, depressive symptoms, middle aged, Epidemiology, nuclear magnetic resonance imaging, Generalized estimating equation, Depression (differential diagnoses), neuroimaging, Depression, adult, disease course, cardiovascular, article, Brain, vascular disease, Middle Aged, medical history, Magnetic Resonance Imaging, Psychiatry and Mental health, female, priority journal, brain size, depression, Brain size, epidemiology, Female, Psychology, Clinical psychology, Patient Health Questionnaire 9, MRI, medicine.medical_specialty, Neuroimaging, educational status, 03 medical and health sciences, male, Internal medicine, medicine, Journal Article, follow up, Humans, Medical history, human, Aged, Psychiatric Status Rating Scales, Vascular disease, medicine.disease, major clinical study, 030227 psychiatry, 030217 neurology & neurosurgery, Follow-Up Studies

الوصف: Objective: To estimate the association between hippocampal and total brain volume and the course of depressive symptoms over eight years of follow-up in patients with a history of vascular disease. Method: Within the SMART-Medea study, 636 participants (62 ± 10 years) had a 1.5-tesla brain MRI obtaining hippocampal and total brain volumes. Depressive symptoms were assessed with the Patient Health Questionnaire-9 biannually during eight-year follow-up. Generalized estimating equation models with robust standard errors were used to assess the associations of hippocampal and total brain volumes with depressive symptoms during follow-up adjusting for age, sex, education, and intracranial volume. An interaction term between volume and time (6-month intervals) was included to examine whether the course of depressive symptoms differed according to hippocampal and total brain volume. Results: The mean PHQ-9 score was 2.8 ± 3.5. Smaller hippocampal volumes were associated with an increasing course of depressive symptom levels, while larger volumes were associated with decreasing levels (P-value interaction = 0.07). Smaller total brain volume was associated with consistently higher levels of depressive symptoms, but not with change in course of depressive symptoms (P-value interaction = 0.45). Conclusion: Smaller hippocampal volume but not total brain volume is associated with poorer course of depressive symptoms over eight years of follow-up.

وصف الملف: application/pdf; image/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2300b6856c2603ca0d2d63316900534Test
https://pubmed.ncbi.nlm.nih.gov/27800603Test

المؤلفون: Veen, P.H. van der, Muller, M., Vincken, K.L., Westerink, J., Mali, W.P.T.M., Graaf, Y. van der, Geerlings, M.I., SMART Study Grp

المصدر: Neurobiology of Aging

مصطلحات موضوعية: Atherosclerosis, Brain imaging, Cerebral blood flow, Hemorheology, Magnetic resonance imaging

الوصف: Pathophysiology, epidemiology and therapy of ageing

العلاقة: lumc-id: 4251879; https://hdl.handle.net/1887/106868Test

الإتاحة: https://doi.org/10.1016/j.neurobiolaging.2014.12.019Test
https://hdl.handle.net/1887/106868Test