التفاصيل البيبلوغرافية
| العنوان: |
Interferon signature guiding therapeutic decision making: ruxolitinib as first-line therapy for severe juvenile dermatomyositis? |
| المؤلفون: |
Heinen, André, Schnabel, Anja, Brück, Normi, Smitka, Martin, Wolf, Christine, Lucas, Nadja, Dollinger, Stefanie, Hahn, Gabriele, Günther, Claudia, Berner, Reinhard, Lee-Kirsch, Min Ae, Schuetz, Catharina |
| المصدر: |
Rheumatology; Apr2021, Vol. 60 Issue 4, pe136-e138, 3p |
| مصطلحات موضوعية: |
AUTOANTIBODIES, DERMATOMYOSITIS, MAGNETIC resonance imaging, CREATINE kinase, JANUS kinases, LEG, INTERFERONS, SEVERITY of illness index, TREATMENT effectiveness, MUSCLE strength, NEUROTRANSMITTER uptake inhibitors, MYOGLOBIN, BLOOD coagulation factors, IMMUNOSUPPRESSIVE agents, ADOLESCENCE |
| مستخلص: |
The article presents a case report of a 14-year-old boy with anti-nuclear matrix protein-2 (NXP2) positive juvenile dermatomyositis (JDM). Examinations showed pronounced symmetrical muscular weakness leaving him bedridden with elevated levels of creatinine kinase activity, myoglobin, and von-Willebrand antigen among other conditions. Treatment with ruxolitinib resulted in the patient's clinical improvement, normalization of inflammatory markers and increased mobility. |
| قاعدة البيانات: |
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