دورية أكاديمية
Multiparametric Model for Penumbral Flow Prediction in Acute Stroke
| العنوان: | Multiparametric Model for Penumbral Flow Prediction in Acute Stroke |
|---|---|
| المؤلفون: | Livne, Michelle, Kossen, Tabea, Madai, Vince I., Zaro-Weber, Olivier, Moeller-Hartmann, Walter, Mouridsen, Kim, Heiss, Wolf-Dieter, Sobesky, Jan |
| المصدر: | Livne , M , Kossen , T , Madai , V I , Zaro-Weber , O , Moeller-Hartmann , W , Mouridsen , K , Heiss , W-D & Sobesky , J 2017 , ' Multiparametric Model for Penumbral Flow Prediction in Acute Stroke ' , Stroke , vol. 48 , no. 7 , pp. 1849-1854 . https://doi.org/10.1161/STROKEAHA.117.016631Test |
| سنة النشر: | 2017 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | acute stroke, cerebrovascular circulation, magnetic resonance imaging, perfusion imaging, positron emission tomography, ACUTE ISCHEMIC-STROKE, POSITRON-EMISSION-TOMOGRAPHY, ARTERIAL INPUT FUNCTION, ENDOVASCULAR THERAPY, PERFUSION MRI, VALIDATION, PET, NEUROPROTECTION, THRESHOLD, SELECTION |
| الوصف: | Background and Purpose-Identification of salvageable penumbra tissue by dynamic susceptibility contrast magnetic resonance imaging is a valuable tool for acute stroke patient stratification for treatment. However, prior studies have not attempted to combine the different perfusion maps into a predictive model. In this study, we established a multiparametric perfusion imaging model and cross-validated it using positron emission tomography perfusion for detection of penumbral flow. Methods-In a retrospective analysis of 17 subacute stroke patients with consecutive magnetic resonance imaging and H2O15 positron emission tomography scans, perfusion maps of cerebral blood flow, cerebral blood volume, mean transit time, time-to-maximum, and time-to-peak were constructed and combined using a generalized linear model (GLM). Both the GLM maps and the single perfusion maps alone were cross-validated with positron emission tomography-cerebral blood flow scans to predict penumbral flow on a voxel-wise level. Performance was tested by receiver-operating characteristics curve analysis, that is, the area under the curve, and the models' fits were compared using the likelihood ratio test. Results-The GLM demonstrated significantly improved model fit compared with each of the single perfusion maps (P Conclusions-Our results support a dynamic susceptibility contrast magnetic resonance imaging-based GLM as an improved model for penumbral flow prediction in stroke patients. With given perfusion maps, this model is a straightforward and observer-independent alternative for therapy stratification. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://pure.au.dk/portal/en/publications/e5b08e06-0869-4340-abab-c472243e9701Test |
| DOI: | 10.1161/STROKEAHA.117.016631 |
| الإتاحة: | https://doi.org/10.1161/STROKEAHA.117.016631Test https://pure.au.dk/portal/en/publications/e5b08e06-0869-4340-abab-c472243e9701Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.95854C57 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1161/STROKEAHA.117.016631 |
|---|