التفاصيل البيبلوغرافية
| العنوان: |
Virulent Mycobacterium bovis Beijing Strain Activates the NLRP7 Inflammasome in THP-1 Macrophages. |
| المؤلفون: |
Zhou, Yang1 zhouxm@cau.edu.cn, Shah, Syed Zahid Ali1, Yang, Lifeng1, Zhang, Zhongqiu2, Zhou, Xiangmei1, Zhao, Deming1 zhaodm@cau.edu.cn |
| المصدر: |
PLoS ONE. 4/4/2016, Vol. 11 Issue 4, p1-13. 13p. |
| مصطلحات موضوعية: |
*TUBERCULOSIS, *MYCOBACTERIUM bovis, *MICROBIAL virulence, *INFLAMMASOMES, *MACROPHAGES |
| مصطلحات جغرافية: |
BEIJING (China) |
| مستخلص: |
Mycobacterium bovis is the causative agent of tuberculosis in a wide range of mammals, including humans. Macrophages are the first line of host defense. They secrete proinflammatory cytokines, such as interleukin-1 beta (IL-1β), in response to mycobacterial infection, but the underlying mechanisms by which human macrophages are activated and release IL-1β following M. bovis infection are poorly understood. Here we show that the ‘nucleotide binding and oligomerization of domain-like receptor (NLR) family pyrin domain containing 7 protein’ (NLRP7) inflammasome is involved in IL-1β secretion and caspase-1 activation induced by M. bovis infection in THP-1 macrophages. NLRP7 inflammasome activation promotes the induction of pyroptosis as well as the expression of tumor necrosis factor alpha (TNF-α), Chemokine (C-C motif) ligand 3 (CCL3) and IL-1β mRNAs. Thus, the NLRP7 inflammasome contributes to IL-1β secretion and induction of pyroptosis in response to M. bovis infection in THP-1 macrophages. [ABSTRACT FROM AUTHOR] |
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