دورية أكاديمية
أعرض في EDS

Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity.

التفاصيل البيبلوغرافية
العنوان: Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity.
المؤلفون: Falck-Jones, Sara1, Vangeti, Sindhu1, Meng Yu1, Falck-Jones, Ryan2,3, Cagigi, Alberto1, Badolati, Isabella1, Österberg, Björn1, Lautenbach, Maximilian Julius4, Åhlberg, Eric1, Ang Lin1,5, Lepzien, Rico1, Szurgot, Inga1, Lenart, Klara1, Hellgren, Fredrika1, Maecker, Holden6, Sälde, Jörgen7, Albert, Jan8,9, Johansson, Niclas4,10, Bell, Max2,3, Loré, Karin1
المصدر: Journal of Clinical Investigation. 3/15/2021, Vol. 131 Issue 6, p1-14. 14p.
مصطلحات موضوعية: *MYELOID-derived suppressor cells, *COVID-19, *LYMPHOPENIA, *BLOOD cells, *RESPIRATORY infections, *T cells
مستخلص: The immunopathology of coronavirus disease 2019 (COVID-19) remains enigmatic, causing immunodysregulation and T cell lymphopenia. Monocytic myeloid-derived suppressor cells (M-MDSCs) are T cell suppressors that expand in inflammatory conditions, but their role in acute respiratory infections remains unclear. We studied the blood and airways of patients with COVID-19 across disease severities at multiple time points. M-MDSC frequencies were elevated in blood but not in nasopharyngeal or endotracheal aspirates of patients with COVID-19 compared with healthy controls. M-MDSCs isolated from patients with COVID-19 suppressed T cell proliferation and IFN-γ production partly via an arginase 1-dependent (Arg-1-dependent) mechanism. Furthermore, patients showed increased Arg-1 and IL-6 plasma levels. Patients with COVID-19 had fewer T cells and downregulated expression of the CD3ζ chain. Ordinal regression showed that early M-MDSC frequency predicted subsequent disease severity. In conclusion, M-MDSCs expanded in the blood of patients with COVID-19, suppressed T cells, and were strongly associated with disease severity, indicating a role for M-MDSCs in the dysregulated COVID-19 immune response. [ABSTRACT FROM AUTHOR]
قاعدة البيانات: Academic Search Index
الوصف
تدمد:00219738
DOI:10.1172/JCI144734