التفاصيل البيبلوغرافية
| العنوان: |
Connective tissue diseases: The conundrum of B cell depletion in SLE. |
| المؤلفون: |
Sanz, Iñaki1 ignacio_sanz@urmc.rochester.edu, Sanz, Iñaki (AUTHOR) |
| المصدر: |
Nature Reviews Rheumatology. Jun2009, Vol. 5 Issue 6, p304-305. 2p. 3 Black and White Photographs. |
| مصطلحات موضوعية: |
*DRUG efficacy, *RITUXIMAB, *ADRENOCORTICAL hormones, *SYSTEMIC lupus erythematosus treatment, *LUPUS nephritis, *B cells, *LYMPHOID tissue, *THERAPEUTICS |
| مستخلص: |
Two consecutive trials of rituximab, a B-cell-depleting anti-CD20 monoclonal antibody, have threatened the future of B-cell-targeted therapy for systemic lupus erythematosus (SLE). While rumors of the demise of this approach might be greatly exaggerated, the outcomes of these studies should force academics and the pharmaceutical industry back to the drawing board. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
