Neutrophil-to-lymphocyte ratio: A potential new peripheral biomarker of suicidal behavior
| العنوان: | Neutrophil-to-lymphocyte ratio: A potential new peripheral biomarker of suicidal behavior |
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| المؤلفون: | Aurélie Cazals, Iciar Abad, Emilie Olié, Luis Jiménez-Treviño, Ángela Velasco, Julia Rodríguez-Revuelta, Paz García-Portilla, Lorena de la Fuente-Tomás, Julio Bobes, Laura Gutierrez, Sébastien Guillaume, Abel Diego Fernández-Peláez, Pilar A. Saiz, Philippe Courtet |
| المساهمون: | Salvy-Córdoba, Nathalie, University of Oviedo, Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Fondation FondaMental [Créteil], Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Mental Health Services of Principado de Asturias (SESPA), Universidad de Oviedo [Oviedo], Hôpital Lapeyronie [Montpellier] (CHU) |
| المصدر: | RUO. Repositorio Institucional de la Universidad de Oviedo instname European Psychiatry European Psychiatry, Cambridge University press, 2020, 63 (1), pp.e14. ⟨10.1192/j.eurpsy.2019.20⟩ European Psychiatry : the journal of the Association of European Psychiatrists |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Neutrophils, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Poison control, Suicide, Attempted, Suicide vulnerability, MESH: Logistic Models, MESH: Neutrophils, Logistic regression, Gastroenterology, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, Lymphocytes, Neutrophil-to-lymphocyte ratio, MESH: Middle Aged, MESH: Suicidal Ideation, Middle Aged, Prognosis, Psychiatry and Mental health, MESH: Suicide, Attempted, Biomarker (medicine), Major depressive disorder, Female, neutrophil-tolymphocyte ratio, Research Article, Adult, medicine.medical_specialty, Trait marker, MESH: Depressive Disorder, Major, MESH: Prognosis, Suicidal Ideation, Internal medicine, medicine, Humans, Neutrophil to lymphocyte ratio, [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity, Retrospective Studies, Depressive Disorder, Major, MESH: Humans, Suicide attempt, business.industry, MESH: Adult, MESH: Retrospective Studies, Odds ratio, medicine.disease, Confidence interval, MESH: Male, Logistic Models, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, MESH: Biomarkers, MESH: Lymphocytes, business, MESH: Female, Biomarkers |
| الوصف: | Background. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) have emerged as important peripheral inflammatory biomarkers. Recent data suggest a possible role of the immune system in the pathophysiology of suicidal behavior (SB). The aim of this study is to evaluate the association among NLR, MLR, and PLR and SB in patients with major depressive disorder (MDD), and to test its validity as a biomarker for suicidality. Methods. We evaluated 538 patients with MDD (mean age [standard deviation] = 43.87 [14.36] years; females: 68.8%). A logistic regression model was estimated to determine the independent factors associated with suicide risk in patients with and without a history of suicide attempt (SA). Results. Three hundred ninety-three patients (74.7%) had a personal history of SA. Patients with a previous SA were more frequently female (71.9% vs. 59.6%; p = 0.007), significantly younger (41.20 vs. 51.77 years; p p p = 0.001; 127.90 vs. 109.97, p = 0.007, respectively). In the final logistic regression model, after controlling for age, sex, and depression severity, NLR was significantly associated with SB (β = 0.489, p = 0.000; odds ratio [95% confidence intervals] = 1.631 [1.266–2.102]). We propose a cut-off value of NLR = 1.30 (sensitivity = 75% and specificity = 35%). Conclusions. Our data suggest that NLR may be a valuable, reproducible, easily accessible, and cost-effective strategy to determine suicide risk in MDD. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0924-9338 1778-3585 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff9f7347770ca8c01f6637a1bdf730fTest http://hdl.handle.net/10651/54242Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0ff9f7347770ca8c01f6637a1bdf730f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09249338 17783585 |
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