دورية أكاديمية
1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
| العنوان: | 1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development |
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| المؤلفون: | Wang, Ting, Wang, Zheng, de Fabritus, Lauriane, Tao, Jinglian, Saied, Essa, Lee, Ho-Joon, Ramazanov, Bulat, Jackson, Benjamin, Burkhardt, Daniel, Parker, Mikhail, Gleinich, Anne, Wang, Zhirui, Seo, Dong Eun, Zhou, Ting, Xu, Shihao, Alecu, Irina, Azadi, Parastoo, Arenz, Christoph, Hornemann, Thorsten, Krishnaswamy, Smita, van de Pavert, Serge, Kaech, Susan, Ivanova, Natalia, Santori, Fabio |
| المساهمون: | Yale University New Haven, Qingdao University (QDU), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Georgia USA, Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin (HU Berlin), The Salk Institute for Biological Studies, Université d'Ottawa Ontario (uOttawa), Universität Zürich Zürich = University of Zurich (UZH), ANR-17-CE13-0029,ATTRACT,L'attraction et le rôle des cellules immunitaires innées dans les lésions cérébrales.(2017) |
| المصدر: | ISSN: 1534-5807 ; Developmental Cell ; https://amu.hal.science/hal-03566022Test ; Developmental Cell, 2021, 56 (22), pp.3128-3145.e15. ⟨10.1016/j.devcel.2021.10.018⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | Aix-Marseille Université: HAL |
| مصطلحات موضوعية: | NR2F1, NR2F2, COUP-TF, NR2F6, sphingolipid, 1-deoxysphingosine, cardiomyocyte, SPTLC2, metabolism, lymphatic, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Identification of physiological modulators of nuclear hormone receptor (NHR) activity is paramount for understanding the link between metabolism and transcriptional networks that orchestrate development and cellular physiology. Using libraries of metabolic enzymes alongside their substrates and products, we identify 1-deoxysphingosines as modulators of the activity of NR2F1 and 2 (COUP-TFs), which are orphan NHRs that are critical for development of the nervous system, heart, veins, and lymphatic vessels. We show that these non-canonical alanine-based sphingolipids bind to the NR2F1/2 ligand-binding domains (LBDs) and modulate their transcriptional activity in cell-based assays at physiological concentrations. Furthermore, inhibition of sphingolipid biosynthesis phenocopies NR2F1/2 deficiency in endothelium and cardiomyocytes, and increases in 1-deoxysphingosine levels activate NR2F1/2-dependent differentiation programs. Our findings suggest that 1-deoxysphingosines are physiological regulators of NR2F1/2-mediated transcription. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03566022; https://amu.hal.science/hal-03566022Test; https://amu.hal.science/hal-03566022/documentTest; https://amu.hal.science/hal-03566022/file/1-s2.0-S1534580721008492-main1-deoxysphingolipids%20SVDP%20version%203.pdfTest |
| DOI: | 10.1016/j.devcel.2021.10.018 |
| الإتاحة: | https://doi.org/10.1016/j.devcel.2021.10.018Test https://amu.hal.science/hal-03566022Test https://amu.hal.science/hal-03566022/documentTest https://amu.hal.science/hal-03566022/file/1-s2.0-S1534580721008492-main1-deoxysphingolipids%20SVDP%20version%203.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.2BC7855E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.devcel.2021.10.018 |
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