التفاصيل البيبلوغرافية
| العنوان: |
ECL-IAA and ECL-GADA Can Identify High-Risk Single Autoantibody-Positive Relatives in the TrialNet Pathway to Prevention Study. |
| المؤلفون: |
Steck, Andrea K.1 andrea.steck@ucdenver.edu, Fouts, Alexandra1, Dongmei Miao1, Zhiyuan Zhao1, Dong, Fran1, Sosenko, Jay2, Gottlieb, Peter1, Rewers, Marian J.1, Liping Yu1 liping.yu@ucdenver.edu, Miao, Dongmei3 (AUTHOR), Zhao, Zhiyuan3 (AUTHOR), Yu, Liping3 (AUTHOR), TrialNet Study Group (CORPORATE AUTHOR) |
| المصدر: |
Diabetes Technology & Therapeutics. Jul2016, Vol. 18 Issue 7, p410-414. 5p. |
| مصطلحات موضوعية: |
*AUTOANTIBODIES, *RELATIVES, *ISLANDS of Langerhans, *DIABETES, *ELECTROCHEMILUMINESCENCE, *AUTOANTIBODY analysis, *ENZYME analysis, *TYPE 1 diabetes, *IMMUNOGLOBULIN analysis, *ANTIGEN-antibody reactions, *ENZYMES, *LIGHT, *LONGITUDINAL method, *RADIOIMMUNOASSAY, *RESEARCH funding, *RISK assessment, *DIAGNOSIS |
| مستخلص: |
Background: Relatives with single positive islet autoantibodies have a much lower risk of progression to diabetes than those with multiple autoantibodies.Materials and Methods: TrialNet subjects positive for single autoantibody to insulin (mIAA) (n = 50) or single autoantibody to glutamic acid decarboxylase (GADA) (n = 50) were analyzed using new electrochemiluminescence (ECL) assays (ECL-IAA and ECL-GADA, respectively) at their initial visit and longitudinally over time. Affinity assays were performed on a subset of single autoantibody-positive subjects at initial and most recent visits.Results: After a mean follow-up of 5.3 years, 20 subjects developed type 1 diabetes. Among either single GADA or single mIAA subjects, those who were positive in the ECL assay showed higher affinity at the initial visit, and affinity results stayed consistent over time. No converting events from low to high or high to low affinity were seen over time.Conclusions: Confirmed positivity for ECL is associated with high affinity and can help staging of risk for type 1 diabetes in single autoantibody-positive subjects. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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