دورية أكاديمية
Neurological Screening in Elderly Liver Transplantation Candidates: A Single Center Experience
| العنوان: | Neurological Screening in Elderly Liver Transplantation Candidates: A Single Center Experience |
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| المؤلفون: | Federica Avorio, Gianvincenzo Sparacia, Giovanna Russelli, Aurelio Seidita, Giuseppe Mamone, Rossella Alduino, Fabio Tuzzolino, Salvatore Gruttadauria, Roberto Miraglia, Matteo Bulati, Vincenzina Lo Re |
| المصدر: | Neurology International, Vol 14, Iss 1, Pp 245-255 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Internal medicine LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | cerebral small vessel disease, liver transplantation, brain magnetic resonance imaging elderly age-related diseases, Medicine, Internal medicine, RC31-1245, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Background: Cerebral small vessels disease (cSVD) is an age-related disorder and risk factor for stroke and cognitive/motor impairments. Neurological complications (NCs) are among the causes of adverse outcomes in older liver transplant recipients. This study sought to determine whether cSVD predicts acute NCs in over 65-year-old liver transplant patients. Methods: Data were collected, from a retrospective medical chart review, of 22 deceased donor liver transplant recipients aged 65 years or older with a pre-operative brain magnetic resonance imaging (MRI). We used the Fazekas score (0–3) as a quantitative measurement of the vascular lesion load seen in the MRI. We analyzed all post-operative acute NCs occurring during the hospital stay and any other non-NC. Results: cSVD was recognized in all patients. Neurological complications (NCs) occurred in 18.1% of patients with toxic-metabolic encephalopathy the most frequent diagnosis (13.64%). More severe cSVD was associated with seizures (p = 0.0362), longer hospital stay (p 0.0299), and disability (p 0.0134). In our elderly cohort, hepatic encephalopathy (HE) (p 0.0287) and ascites (p 0.0270) were predictors of NCs after liver transplantation. Ascites and/or variceal bleeding and severity of liver disease were associated with adverse post-operative outcomes. The small sample size limited the statistical analysis power. Conclusions: We present the preliminary data of a single-center retrospective study aimed at understanding the cSVD role on NCs and non-NCs after a liver transplantation in elderly patients. This would encourage a more appropriate multicenter prospective study that will definitely confirm if a neurological screening in old age liver transplant candidates is appropriate. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2035-8377 |
| العلاقة: | https://www.mdpi.com/2035-8377/14/1/19Test; https://doaj.org/toc/2035-8377Test |
| DOI: | 10.3390/neurolint14010019 |
| الوصول الحر: | https://doaj.org/article/8ed1406382fd47f8a113bb628856d89aTest |
| رقم الانضمام: | edsdoj.8ed1406382fd47f8a113bb628856d89a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20358377 |
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| DOI: | 10.3390/neurolint14010019 |