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المؤلفون: Vikram Arya, Xinyuan Zhang, Justin C. Earp, Kellie S. Reynolds, Yaning Wang, Manuela Grimstein, Hao Zhu, Yuching Yang, Eliford Kitabi, Jianghong Fan
المصدر: Clinical Pharmacology & Therapeutics. 111:624-634
مصطلحات موضوعية: Adult, Male, Drug, Physiologically based pharmacokinetic modelling, Multiple Organ Failure, media_common.quotation_subject, Pharmacology, Models, Biological, Pharmacokinetics, Humans, Medicine, Tissue Distribution, Pharmacology (medical), Lung, Active metabolite, media_common, Alanine, Nucleoside analogue, business.industry, Organ dysfunction, Prodrug, Adenosine Monophosphate, medicine.anatomical_structure, Liver, medicine.symptom, business, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbff2b27a48eab542615954b8b8f186Test
https://doi.org/10.1002/cpt.2445Test -
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المؤلفون: Karel Allegaert, Olusola Olafuyi, Mohammad Yaseen Abbasi
المساهمون: Pharmacy
المصدر: Biopharmaceutics and Drug Disposition, 42(9), 401-417. John Wiley & Sons Ltd.
مصطلحات موضوعية: Adult, Cardiac output, Physiologically based pharmacokinetic modelling, Cmax, Pharmaceutical Science, Pharmacology, Models, Biological, Sulfation, Pharmacokinetics, Humans, Medicine, Pharmacology (medical), Cardiac Output, Child, Acetaminophen, business.industry, digestive, oral, and skin physiology, Infant, Newborn, General Medicine, Metabolism, Kinetics, Liver, business, Perfusion, medicine.drug
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4756f5053dbc4508cc6bd89933c26c5Test
https://pure.eur.nl/en/publications/82accc24-ff11-4122-bb36-6a1e9aa46640Test -
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المصدر: Pharmaceutical Research
مصطلحات موضوعية: Male, Pharmaceutical Science, Pharmacology, Feces, Ethnicity, ATP Binding Cassette Transporter, Subfamily G, Member 2, Gemfibrozil, Drug Interactions, Pharmacology (medical), Rosuvastatin Calcium, media_common, Liver-Specific Organic Anion Transporter 1, Probenecid, Age Factors, Neoplasm Proteins, Liver, Area Under Curve, Molecular Medicine, Rifampin, Research Paper, Biotechnology, medicine.drug, Adult, Drug, Physiologically based pharmacokinetic modelling, Drug-drug interactions (DDIs), Organic anion transporting polypeptide 1B1/1B3 (OATP1B1/1B3), media_common.quotation_subject, Cmax, Models, Biological, Rosuvastatin, Solute Carrier Organic Anion Transporter Family Member 1B3, Sex Factors, Pharmacokinetics, Physiologically based pharmacokinetic modeling (PBPK), medicine, Humans, CYP2C9, business.industry, Body Weight, Organic Chemistry, Model-informed drug discovery and development (MID3), nutritional and metabolic diseases, Biological Transport, Body Height, business, Software
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265ab43cfe81e3d0230c0120c21459bfTest
https://doi.org/10.1007/s11095-021-03109-6Test -
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المؤلفون: Sirisha Tadimalla, Daniel Scotcher, Adam S. Darwich, Steven Sourbron, Kayode Ogungbenro, Gunnar Schütz, Sabina Ziemian, Nicola Melillo, Aleksandra Galetin
المصدر: Molecular Pharmaceutics
Mol. Pharmaceuticsمصطلحات موضوعية: Gadolinium DTPA, Male, Physiologically based pharmacokinetic modelling, Imaging biomarker, quantitative translation, physiologically based pharmacokinetic model, Biological Transport, Active, Contrast Media, Organic Anion Transporters, Pharmaceutical Science, drug transporters, Pharmacology, Article, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, imaging biomarker, Drug Interactions, drug−drug interactions, Cells, Cultured, medicine.diagnostic_test, Chemistry, Multidrug resistance-associated protein 2, Transporter, Magnetic resonance imaging, Magnetic Resonance Imaging, Rats, medicine.anatomical_structure, Liver, gadoxetate, Hepatocyte, Models, Animal, Hepatocytes, Molecular Medicine, hepatobiliary excretion, Rifampin, Biomarkers
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8273f7c9644e0d3b1f1acd044719deeeTest
https://doi.org/10.1021/acs.molpharmaceut.1c00206Test -
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المؤلفون: Lars M. Blank, Elke Schaeffeler, Annika R. P. Schneider, Ali Yilmaz, Ute Hofmann, Lars Kuepfer, Rolf Burghaus, Jan-Frederik Schlender, Rebekka Fendt, Reinhold Kerb, Jörg Lippert, Matthias Schwab
المصدر: CPT: pharmacometrics & systems pharmacology
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 782-793 (2021)مصطلحات موضوعية: Adult, Male, Physiologically based pharmacokinetic modelling, Adolescent, RM1-950, Hematocrit, Models, Biological, Article, Data-driven, Clinical study, Young Adult, chemistry.chemical_compound, Pharmacokinetics, Cytochrome P-450 CYP1A2, Caffeine, Individual data, Statistics, Healthy volunteers, medicine, Humans, Computer Simulation, Pharmacology (medical), Precision Medicine, Mathematics, Dose-Response Relationship, Drug, medicine.diagnostic_test, Research, Articles, Middle Aged, Magnetic Resonance Imaging, Phenotype, Liver, chemistry, Modeling and Simulation, Female, Therapeutics. Pharmacology, Glomerular Filtration Rate
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2fdb9afac270a68255a033424eb1e5fTest
https://doi.org/10.1002/psp4.12646Test -
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المؤلفون: Yurong Lai, Xiaomin Liang
المصدر: Expert Opinion on Drug Metabolism & Toxicology. 17:869-886
مصطلحات موضوعية: Drug, Physiologically based pharmacokinetic modelling, media_common.quotation_subject, Hepatic clearance, Computational biology, Toxicology, Models, Biological, 030226 pharmacology & pharmacy, 03 medical and health sciences, Animal data, 0302 clinical medicine, Pharmacokinetics, Animals, Humans, Medicine, Drug Interactions, media_common, Pharmacology, Drug discovery, business.industry, Membrane Transport Proteins, Reproducibility of Results, Biliary secretion, Biological Transport, Transporter, Haplorhini, General Medicine, Liver, Pharmaceutical Preparations, 030220 oncology & carcinogenesis, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894d91880eed681db968b15c4cf0763fTest
https://doi.org/10.1080/17425255.2021.1912012Test -
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المؤلفون: Patrick Poulin, Sami Haddad, Michel Bteich
المصدر: Journal of Pharmaceutical Sciences. 110:1385-1391
مصطلحات موضوعية: Drug, Physiologically based pharmacokinetic modelling, media_common.quotation_subject, Pharmaceutical Science, Orosomucoid, 02 engineering and technology, Pharmacology, Models, Biological, 030226 pharmacology & pharmacy, 03 medical and health sciences, Perampanel, chemistry.chemical_compound, 0302 clinical medicine, Albumins, medicine, Animals, media_common, chemistry.chemical_classification, biology, Albumin, Blood Proteins, 021001 nanoscience & nanotechnology, Blood proteins, Rats, 3. Good health, medicine.anatomical_structure, Liver, Pharmaceutical Preparations, chemistry, Hepatocyte, biology.protein, 0210 nano-technology, Glycoprotein, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc86a056a4a1dbbb28fb443ad383018Test
https://doi.org/10.1016/j.xphs.2020.11.009Test -
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المؤلفون: Hong Shen, Karelle Ménochet, Yueping Zhang, Hiroyuki Takita, Kayode Ogungbenro, Shelby Barnett, Aleksandra Galetin
المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 137-147 (2021)
Takita, H, Barnett, S, Zhang, Y, Ménochet, K, Shen, H, Ogungbenro, K & Galetin, A 2021, ' PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter-Individual Variability ', CPT: Pharmacometrics and Systems Pharmacology . https://doi.org/10.1002/psp4.12582Test
CPT: Pharmacometrics & Systems Pharmacologyمصطلحات موضوعية: Male, Coproporphyrins, Physiologically based pharmacokinetic modelling, Genotype, Physiology, Urine, Kidney, Models, Biological, Sensitivity and Specificity, Article, Drug Development, Pharmacokinetics, Liver tissue, Ethnicity, Humans, Medicine, Drug Interactions, Pharmacology (medical), Coproporphyrin I, Observer Variation, Sex Characteristics, biology, Liver-Specific Organic Anion Transporter 1, business.industry, Research, lcsh:RM1-950, Biological Transport, Articles, Healthy Volunteers, lcsh:Therapeutics. Pharmacology, Liver, Modeling and Simulation, biology.protein, Biomarker (medicine), Female, SLCO1B1, business, Biomarkers
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294c4b448515b976395f4a3a766cae29Test
https://doaj.org/article/bcb3eb0e26ae41549ab32adc6ba6bc94Test -
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المؤلفون: Zubida M. Al-Majdoub, Jill Barber, Brahim Achour, Sheila Annie Peters, Amin Rostami-Hodjegan, Areti-Maria Vasilogianni
المصدر: Vasilogianni, AM, Al-Majdoub, Z M, Achour, B, Peters, S A, Rostami-Hodjegan, A & Barber, J 2022, ' Proteomics of Colorectal Cancer Liver Metastasis: a Quantitative Focus on Drug Elimination and Pharmacodynamics Effects ', British Journal of Clinical Pharmacology, vol. 88, no. 4, pp. 1811-1823 . https://doi.org/10.1111/bcp.15098Test, https://doi.org/10.1111/bcp.15098Test
Vasilogianni, A M, Al-Majdoub, Z M, Achour, B, Peters, S A, Rostami-Hodjegan, A & Barber, J 2022, ' Proteomics of colorectal cancer liver metastasis : A quantitative focus on drug elimination and pharmacodynamics effects ', British Journal of Clinical Pharmacology, vol. 88, no. 4, pp. 1811-1823 . https://doi.org/10.1111/bcp.15098Testمصطلحات موضوعية: Proteomics, Physiologically based pharmacokinetic modelling, PBPK, Colorectal cancer, Population, Drug Elimination Routes, transporters, Biology, Metastasis, drug-metabolizing enzymes, proteomics, colorectal cancer liver, medicine, Humans, metastasis, Pharmacology (medical), education, Pharmacology, education.field_of_study, receptor tyrosine kinases, Liver Neoplasms, Cancer, Membrane Transport Proteins, medicine.disease, Liver, inflammation, QconCAT, Cancer research, Liver function, Colorectal Neoplasms, Drug metabolism
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c00124af7480bee0152684ed6d14f81Test
https://doi.org/10.1111/bcp.15098Test -
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المصدر: Clinical Pharmacology & Therapeutics. 109:1618-1630
مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, Antifungal Agents, Cardiotonic Agents, Adolescent, Drug-Related Side Effects and Adverse Reactions, Metabolite, Ontogeny, Pharmacology, Pediatrics, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Cytochrome P-450 CYP3A, Humans, Medicine, Drug Interactions, Ivabradine, Pharmacology (medical), Child, CYP3A4, business.industry, Infant, Newborn, Cytochrome P-450 CYP3A Inducers, Infant, Ketoconazole, Liver, Drug development, chemistry, Child, Preschool, 030220 oncology & carcinogenesis, Pharmacodynamics, Cytochrome P-450 CYP3A Inhibitors, business, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6333d3c2ba057ecd8ac31b9065985dTest
https://doi.org/10.1002/cpt.2134Test
