يعرض 1 - 10 نتائج من 595 نتيجة بحث عن '"Lipoxygenase"', وقت الاستعلام: 1.63s تنقيح النتائج
  1. 1
    Natural Inhibitors against Potential Targets of Cyclooxygenase, Lipoxygenase and Leukotrienes

    المؤلفون: Sisir Nandi, Sudatta Dey, Rishita Dey, Asmita Samadder, Anil Saxena

    المصدر: Combinatorial Chemistry & High Throughput Screening. 25:2341-2357

    مصطلحات موضوعية: Pain, Inflammation, Osteoarthritis, Pharmacology, chemistry.chemical_compound, Lipoxygenase, Drug Discovery, medicine, Humans, Pain Management, Cyclooxygenase Inhibitors, Lipoxygenase Inhibitors, biology, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Organic Chemistry, Cancer, General Medicine, medicine.disease, Computer Science Applications, chemistry, Rheumatoid arthritis, Toxicity, biology.protein, Leukotriene Antagonists, Arachidonic acid, Cyclooxygenase, medicine.symptom, business

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fbd5d995ba1b23b58e403774b6fef7Test
    https://doi.org/10.2174/1386207325666210917111847Test


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  2. 2
    Utility of novel 2-furanones in synthesis of other heterocyclic compounds having anti-inflammatory activity with dual COX2/LOX inhibition

    المؤلفون: Mosaad S. Mohamed, Shahenda Mahgoub, Hend Medhat El-Shanbaky, Rania H. Abd El-Hameed, Sahar A. Ali

    المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry
    article-version (VoR) Version of Record
    Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 977-986 (2021)

    مصطلحات موضوعية: Chemokine, medicine.drug_class, Inflammation, RM1-950, 01 natural sciences, Anti-inflammatory, Lipoxygenase, Structure-Activity Relationship, 4-Butyrolactone, Heterocyclic Compounds, Drug Discovery, medicine, Humans, 15-LOX inhibitors, Lipoxygenase Inhibitors, Pyridazinone, anti-inflammatory, Pharmacology, chemistry.chemical_classification, Arachidonate 5-Lipoxygenase, biology, Cyclooxygenase 2 Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Tumor Necrosis Factor-alpha, TNF-α inhibitor, Anti-Inflammatory Agents, Non-Steroidal, General Medicine, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Biochemistry, Cyclooxygenase 2, biology.protein, Tumor necrosis factor alpha, selective COX-2 inhibitor, Cyclooxygenase, Therapeutics. Pharmacology, medicine.symptom, Research Article, Research Paper

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19667daf6d13bb3c9f348e6d97dfab69Test
    http://europepmc.org/articles/PMC8118430Test


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  3. 3
    Lipoxygenase Inhibitors as Cancer Chemopreventives: Discovery, Recent Developments and Future Perspectives

    المؤلفون: Afshin Zarghi, Mohammad Mahboubi-Rabbani

    المصدر: Current Medicinal Chemistry. 28:1143-1175

    مصطلحات موضوعية: Male, Leukotrienes, Peptidomimetic, Anti-Inflammatory Agents, Inflammation, Biology, 01 natural sciences, Biochemistry, 03 medical and health sciences, Lipoxygenase, chemistry.chemical_compound, Neoplasms, Drug Discovery, Gene expression, medicine, Animals, Humans, Cytotoxic T cell, Lipoxygenase Inhibitors, 0101 mathematics, 030304 developmental biology, Pharmacology, chemistry.chemical_classification, 0303 health sciences, Arachidonate 5-Lipoxygenase, Organic Chemistry, Cancer, medicine.disease, 010101 applied mathematics, Enzyme, chemistry, Cancer research, biology.protein, Molecular Medicine, Arachidonic acid, medicine.symptom

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445a5fdbccc05b95edce1e6233b5ae4eTest
    https://doi.org/10.2174/0929867326666191210104820Test


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  4. 4
    The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications

    المؤلفون: Bivek Singh, Nour Ammar, Kuldeep Dhama, Sadeq A. Quraishi, Samuel Pecho-Silva, Mohammed Moustapha Anwar, Zareena Fathah, Alfonso J. Rodriguez-Morales, Rawan Sobhi Utt, Ranjit Sah, Areej Elba, Nohora Cristina Ayola-Serrano, Namrata Roy

    المصدر: Inflammation Research

    مصطلحات موضوعية: 0301 basic medicine, ARDS, Leukotrienes, Necrosis, Immunology, Review, Proinflammatory cytokine, 03 medical and health sciences, Tissue factor, 0302 clinical medicine, medicine, Animals, Humans, Lipoxygenase Inhibitors, Enzyme Inhibitors, Pharmacology, Inflammation, Leukotriene, Arachidonate 5-Lipoxygenase, Arachidonic Acid, biology, business.industry, SARS-CoV-2, 5-LOX inhibitors, Interleukins, COVID-19, medicine.disease, COVID-19 Drug Treatment, Cytokine release syndrome, 030104 developmental biology, Treatment Outcome, Virus Diseases, 030220 oncology & carcinogenesis, Arachidonate 5-lipoxygenase, biology.protein, 5-lipoxygenase, Cytokines, Tumor necrosis factor alpha, medicine.symptom, business, Cytokine Release Syndrome, CRS

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e784dbd316650c21de5dfb1c24d1d6a6Test
    http://europepmc.org/articles/PMC8176665Test


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  5. 5
    5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats

    المؤلفون: Zongduo Guo, Ping Zhang, Liu Liu, Yongbing Deng, Zhaohui He, Yidan Liang, Hong Chen, Zhaosi Zhang, Xiaochuan Sun

    المصدر: Aging (Albany NY)

    مصطلحات موضوعية: Male, Aging, subarachnoid hemorrhage, Morpholines, Administration, Oral, Apoptosis, Inflammation, Pharmacology, Phosphatidylinositol 3-Kinases, chemistry.chemical_compound, early brain injury, Downregulation and upregulation, Animals, Humans, Hydroxyurea, Medicine, LY294002, Lipoxygenase Inhibitors, 5-LOX, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Neurons, Arachidonate 5-Lipoxygenase, biology, business.industry, Cell Biology, Zileuton, Rats, Disease Models, Animal, Infusions, Intraventricular, chemistry, Chromones, Brain Injuries, Arachidonate 5-lipoxygenase, biology.protein, medicine.symptom, business, Proto-Oncogene Proteins c-akt, Signal Transduction, Research Paper, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab727b90d24c0887f137ed7ce4dbcd6Test
    https://doi.org/10.18632/aging.202869Test


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  6. 6
    O-prenylated carbostyrils as a novel class of 15-lipoxygenase inhibitors: Synthesis, characterization, and inhibitory assessment

    المؤلفون: Hossein M. Orafai, Hamid Sadeghian, Seyed Jamal Alavi, Mahdi Hosseini Bafghi, Amir Zebarjadi

    المصدر: Chemical biologydrug designREFERENCES. 98(5)

    مصطلحات موضوعية: Inflammation, Quinolones, Inhibitory postsynaptic potential, Biochemistry, Lipoxygenase, chemistry.chemical_compound, Structure-Activity Relationship, Prenylation, Picrates, Coumarins, Drug Discovery, medicine, Moiety, Arachidonate 15-Lipoxygenase, Humans, Lipoxygenase Inhibitors, IC50, Pharmacology, chemistry.chemical_classification, biology, Organic Chemistry, Biphenyl Compounds, Coumarin, Enzyme, chemistry, biology.protein, Hydroxyquinolines, Molecular Medicine, Soybeans, medicine.symptom

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e3a6772f9318af1e9895adeeb73789Test
    https://pubmed.ncbi.nlm.nih.gov/34453501Test


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  7. 7
    Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR

    المؤلفون: Minakshi A. Meshram, Venkata Rao Kaki, Priyanka N. Makhal, Utkarsha O. Bhise

    المصدر: European journal of medicinal chemistry. 225

    مصطلحات موضوعية: Inflammation, Pharmacology, chemistry.chemical_compound, Lipoxygenase, Drug Discovery, medicine, Animals, Humans, Lipoxygenase Inhibitors, Adverse effect, Biological Products, Arachidonate 5-Lipoxygenase, biology, Cyclooxygenase 2 Inhibitors, Molecular Structure, Chemistry, Organic Chemistry, General Medicine, medicine.disease, Cyclooxygenase 2, Rheumatoid arthritis, Arachidonate 5-lipoxygenase, biology.protein, Arachidonic acid, Cyclooxygenase, medicine.symptom, Pharmacophore

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec66a875b168f9d4ad2cf49b8353df6Test
    https://pubmed.ncbi.nlm.nih.gov/34479036Test


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  8. 8
    Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

    المؤلفون: Simona Pace, Erik Romp, Paul M. Jordan, Hans-Erik Claesson, Jana Gerstmeier, Oliver Werz, Zhigang Rao, Anna Czapka, Charles N. Serhan, Ulrike Garscha, Christian Kretzer, Andreas Koeberle, Markus Werner

    المصدر: The FASEB Journal. 33:6140-6153

    مصطلحات موضوعية: Adult, 0301 basic medicine, Leukotrienes, Prostaglandin Antagonists, Lipoxygenase, Inflammation, Biochemistry, Proinflammatory cytokine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Genetics, medicine, Metabolome, Humans, Cyclooxygenase Inhibitors, Lipoxygenase Inhibitors, Molecular Biology, Cells, Cultured, Leukotriene, Chemistry, Research, Macrophages, Anti-Inflammatory Agents, Non-Steroidal, Lipid signaling, Zileuton, M2 Macrophage, Cell biology, 030104 developmental biology, Prostaglandin-Endoperoxide Synthases, Prostaglandins, Leukotriene Antagonists, Arachidonic acid, medicine.symptom, 030217 neurology & neurosurgery, Biotechnology, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3615047ac5fec69386ed67036e7da14Test
    https://doi.org/10.1096/fj.201802509rTest


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  9. 9
    Exploration of Long-Chain Vitamin e Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation

    المؤلفون: Andreas Koeberle, Denis Séraphin, Stefan Lorkowski, Tiago Rodrigues, Oliver Werz, Daniela Schuster, Dimitri Bréard, Hermann Stuppner, Ida Cerqua, Antonietta Rossi, Simona Pace, Marta C. Marques, Alexander S. Mosig, Paul M. Jordan, Stephan Permann, Jana Gerstmeier, Martin Raasch, Gonçalo J. L. Bernardes, André Gollowitzer, Ulrike Garscha, Chau-Phi Dinh, Alexia Ville, Jean-Jacques Helesbeux, Fiorentina Roviezzo, Guillaume Viault, Elena Brunner, Pascal Richomme, Veronika Temml, Rossella Bilancia, Khaled Alsabil, Konstantin Loeser, Konstantin Neukirch

    المساهمون: Neukirch, K., Alsabil, K., Dinh, C. -P., Bilancia, R., Raasch, M., Ville, A., Cerqua, I., Viault, G., Breard, D., Pace, S., Temml, V., Brunner, E., Jordan, P. M., Marques, M. C., Loeser, K., Gollowitzer, A., Permann, S., Gerstmeier, J., Lorkowski, S., Stuppner, H., Garscha, U., Rodrigues, T., Bernardes, G. J. L., Schuster, D., Seraphin, D., Richomme, P., Rossi, A., Mosig, A. S., Roviezzo, F., Werz, O., Helesbeux, J. -J., Koeberle, A., Neukirch, Konstantin [0000-0003-0630-1624], Dinh, Chau-Phi [0000-0002-3683-3472], Gollowitzer, André [0000-0003-1524-8298], Stuppner, Hermann [0000-0001-8862-0201], Rodrigues, Tiago [0000-0002-1581-5654], Bernardes, Gonçalo J L [0000-0001-6594-8917], Schuster, Daniela [0000-0002-9933-8938], Séraphin, Denis [0000-0002-0509-5788], Mosig, Alexander S [0000-0002-5687-2444], Werz, Oliver [0000-0002-5064-4379], Koeberle, Andreas [0000-0001-6269-5088], Apollo - University of Cambridge Repository, Bernardes, Gonçalo JL [0000-0001-6594-8917]

    المصدر: Journal of Medicinal Chemistry

    مصطلحات موضوعية: medicine.medical_treatment, Administration, Oral, Inflammation, Endogeny, Lipoxygenase Inhibitor, Pharmacology, Article, chemistry.chemical_compound, Structure-Activity Relationship, Immune system, Drug Discovery, medicine, Humans, Vitamin E, Lipoxygenase Inhibitors, Prostaglandin E2, Leukotriene, Arachidonate 5-Lipoxygenase, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Lipid signaling, Recombinant Protein, Recombinant Proteins, Molecular Docking Simulation, Molecular Medicine, medicine.symptom, Resolvin, medicine.drug, Human

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197aa94407387a7b89fbecdcc110c28aTest
    http://hdl.handle.net/11588/879642Test


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  10. 10
    Lipoxygenase Inhibition by Plant Extracts

    المؤلفون: Drago Šubarić, Maja Molnar, Ivica Strelec, Melita Lončarić, Tihomir Moslavac, Valentina Pavić

    المصدر: Biomolecules
    Biomolecules, Vol 11, Iss 152, p 152 (2021)

    مصطلحات موضوعية: plant extracts, Food spoilage, Lipoxygenase, lcsh:QR1-502, Inflammation, Stimulation, Review, Flowers, 01 natural sciences, Biochemistry, lcsh:Microbiology, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, medicine, Animals, Arachidonate 15-Lipoxygenase, Humans, Lipoxygenase Inhibitors, Molecular Biology, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Arachidonate 5-Lipoxygenase, Arachidonic Acid, lipoxygenase, polyphenols, biology, fungi, Fatty Acids, food and beverages, Polyphenols, Hydrogen Peroxide, 3. Good health, 0104 chemical sciences, Oxygen, Plant Leaves, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Polyphenol, biology.protein, Fatty Acids, Unsaturated, Arachidonic acid, medicine.symptom, Oxidation-Reduction, Polyunsaturated fatty acid

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98b336fb16017d9575d9f866f54f9efTest
    http://europepmc.org/articles/PMC7911790Test


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