دورية أكاديمية
Human papilloma virus‐16‐specific CD8+ T‐cell expansions characterize different clinical forms of lichen planus and not lichen sclerosus et atrophicus
| العنوان: | Human papilloma virus‐16‐specific CD8+ T‐cell expansions characterize different clinical forms of lichen planus and not lichen sclerosus et atrophicus |
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| المؤلفون: | Viguier, Manuelle, Pérals, Corine, Poirier, Béatrice, Battistella, Maxime, Aubin, François, Bachelez, Hervé, Prétet, Jean‐luc, Gheit, Tarik, Tommasino, Massimo, Touzé, Antoine, Gougeon, Marie‐lise, Fazilleau, Nicolas |
| المساهمون: | Immuno-Régulation dans les Maladies Auto-Immunes Inflammatoires et le Cancer - EA 7509 (IRMAIC), Université de Reims Champagne-Ardenne (URCA), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur Paris (IP), Service d'anatomo-pathologie Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Genetic skin diseases : from disease mechanism to therapies (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Service de Dermatologie AP-HP Hôpital Saint-Louis, Hopital Saint-Louis AP-HP (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre National de Référence des Papillomavirus (CNRP), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), IRCCS Ist Tumori Giovanni Paolo II, Bari, Italy, Partenaires INRAE, Infectiologie et Santé Publique (UMR ISP), Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), European Regional Development Fund, Grant/Award Number: MP0022856, Institut National de la Sante et de la Recherche Medicale, Region Occitanie Pyrenees-Mediterranee, Grant/Award Number: #1901175, Societe Francaise de Dermatologie et de Pathologie Sexuellement Transmissible |
| المصدر: | ISSN: 0906-6705. |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Université François-Rabelais de Tours: HAL |
| مصطلحات موضوعية: | T-cell, T-cell receptor, cytotoxic T lymphocytes, human papilloma virus, lichen planus, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology |
| الوصف: | International audience ; Lichen planus (LP) is a cutaneomucosal chronic inflammatory disease characterized by a CD8 + cytotoxic T-lymphocytes (CTL) infiltrate. In erosive oral LP, we found HPV16specific activated CTL in lesions, supporting a pathogenic contribution of HPV16. Here, we investigated whether a similar scenario occurs in other clinical forms of LP and in lichen sclerosus et atrophicus (LSA), another chronic disease also affecting the mucosa and/or the skin. Blood CTL from LP and LSA patients expressed significant higher levels of granzyme B, perforin and CD107a proteins than healthy donors. Expansions of TCRVß3 + CTL, with presence of TCR clonotypes identical to those previously detected in erosive oral LP, were found both in blood and mucosal/skin lesions of LP, and not of LSA patients. These expansions were enriched with HPV16-specific CD8 + T-cells as shown by their recognition of the E7 11-20 immunodominant epitope. In LSA patients, the peripheral repertoire of CTL was oligoclonal for TCRVß6 + CTL. Finally, although patients with LP and LSA have developed antibodies against HPV16 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36922453; hal-04075439; https://hal.inrae.fr/hal-04075439Test; https://hal.inrae.fr/hal-04075439/documentTest; https://hal.inrae.fr/hal-04075439/file/2023_Viguier_Exp-Dermatol_early.pdfTest; PUBMED: 36922453; WOS: 000952386100001 |
| DOI: | 10.1111/exd.14788 |
| الإتاحة: | https://doi.org/10.1111/exd.14788Test https://hal.inrae.fr/hal-04075439Test https://hal.inrae.fr/hal-04075439/documentTest https://hal.inrae.fr/hal-04075439/file/2023_Viguier_Exp-Dermatol_early.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-ndTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.A07BB678 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/exd.14788 |
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