دورية أكاديمية
A Neutrophil Timer Coordinates Immune Defense and Vascular Protection
| العنوان: | A Neutrophil Timer Coordinates Immune Defense and Vascular Protection |
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| المؤلفون: | Adrover, Jose M., del Fresno, Carlos, Crainiciuc, Georgiana, Isabel Cuartero, Maria, Casanova-Acebes, Maria, Weiss, Linnea A., Huerga-Encabo, Hector, Silvestre-Roig, Carlos, Rossaint, Jan, Cossio, Itziar, Lechuga-Vieco, Ana V., Garcia-Prieto, Jaime, Gomez-Parrizas, Monica, Quintana, Juan A., Ballesteros, Ivan, Martin-Salamanca, Sandra, Aroca-Crevillen, Alejandra, Chong, Shu Zhen, Evrard, Maximilien, Balabanian, Karl, Lopez, Jorge, Bidzhekov, Kiril, Bachelerie, Frangoise, Abad-Santos, Francisco, Munoz-Calleja, Cecilia, Zarbock, Alexander, Soehnlein, Oliver, Weber, Christian, Ng, Lai Guan, Lopez-Rodriguez, Cristina, Sancho, David, Moro, Maria A., Ibanez, Borja, Hidalgo, Andres |
| المصدر: | Adrover , J M , del Fresno , C , Crainiciuc , G , Isabel Cuartero , M , Casanova-Acebes , M , Weiss , L A , Huerga-Encabo , H , Silvestre-Roig , C , Rossaint , J , Cossio , I , Lechuga-Vieco , A V , Garcia-Prieto , J , Gomez-Parrizas , M , Quintana , J A , Ballesteros , I , Martin-Salamanca , S , Aroca-Crevillen , A , Chong , S Z , Evrard , M , Balabanian , K , Lopez , J , Bidzhekov , K , Bachelerie , F , .... |
| سنة النشر: | 2019 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | FLUORESCENT PROTEIN, LEUKOCYTE ADHESION, BONE-MARROW, CXCR4, SELECTIN, INFLAMMATION, MODULATION, OSCILLATIONS, EXPRESSION, RELEASE |
| الوصف: | Neutrophils eliminate pathogens efficiently but can inflict severe damage to the host if they over-activate within blood vessels. It is unclear how immunity solves the dilemma of mounting an efficient anti-microbial defense while preserving vascular health. Here, we identify a neutrophil-intrinsic program that enabled both. The gene Bmal1 regulated expression of the chemokine CXCL2 to induce chemokine receptor CXCR2-dependent diurnal changes in the transcriptional and migratory properties of circulating neutrophils. These diurnal alterations, referred to as neutrophil aging, were antagonized by CXCR4 (C-X-C chemokine receptor type 4) and regulated the outer topology of neutrophils to favor homeostatic egress from blood vessels at night, resulting in boosted anti-microbial activity in tissues. Mice engineered for constitutive neutrophil aging became resistant to infection, but the persistence of intravascular aged neutrophils predisposed them to thrombo-inflammation and death. Thus, diurnal compartmentalization of neutrophils, driven by an internal timer, coordinates immune defense and vascular protection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.immuni.2019.01.002 |
| الإتاحة: | https://doi.org/10.1016/j.immuni.2019.01.002Test https://cris.maastrichtuniversity.nl/en/publications/b69b3cc7-700e-4b76-b9d0-b82ab19ce068Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.ECA973D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.immuni.2019.01.002 |
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