دورية أكاديمية
Leptin receptor-deficient obese Zucker rats reduce their food intake in response to hypobaric hypoxia.
| العنوان: | Leptin receptor-deficient obese Zucker rats reduce their food intake in response to hypobaric hypoxia. |
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| المؤلفون: | Simler, Nadine, Grosfeld, Alexandra, Peinnequin, André, Guerre-Millo, Michèle, Bigard, André-Xavier |
| المساهمون: | Département des Facteurs Humains, Service de Santé des Armées-Ministère de la Défense, Nutrition, métabolisme, obésité: aspect cellulaire et moléculaire, Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | ISSN: 0193-1849. |
| بيانات النشر: | HAL CCSD American Physiological Society |
| سنة النشر: | 2006 |
| المجموعة: | Archive ouverte du Service de Santé des Armées (HAL) |
| مصطلحات موضوعية: | MESH: Adipose Tissue, MESH: Animals, MESH: Obesity, MESH: RNA, Messenger, MESH: Rats, Zucker, MESH: Receptors, Cell Surface, Leptin, MESH: Reverse Transcriptase Polymerase Chain Reaction, MESH: Vascular Endothelial Growth Factor A, MESH: Anoxia, MESH: Body Weight, MESH: Eating, MESH: Gene Expression, MESH: Hematocrit, MESH: Leptin, MESH: Male, MESH: Neuropeptide Y, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology |
| الوصف: | International audience ; Exposure to hypoxia induces anorexia in humans and rodents, but the role of leptin remains under discussion and that of orexigenic and anorexigenic hypothalamic neuropeptides remains unknown. The present study was designed to address this issue by using obese (Lepr(fa)/Lepr(fa)) Zucker rats, a rat model of genetic leptin receptor deficiency. Homozygous lean (Lepr(FA)/Lepr(FA)) and obese (Lepr(fa)/Lepr(fa)) rats were randomly assigned to two groups, either kept at ambient pressure or exposed to hypobaric hypoxia for 1, 2, or 4 days (barometric pressure, 505 hPa). Food intake and body weight were recorded throughout the experiment. The expression of leptin and vascular endothelial growth factor (VEGF) genes was studied in adipose tissue with real-time quantitative PCR and that of selected orexigenic and anorexigenic neuropeptides was measured in the hypothalamus. Lean and obese rats exhibited a similar hypophagia (38 and 67% of initial values at day 1, respectively, P < 0.01) and initial decrease in body weight during hypoxia exposure. Hypoxia led to increased plasma leptin levels only in obese rats. This resulted from increased leptin gene expression in adipose tissue in response to hypoxia, in association with enhanced VEGF gene expression. Increased hypothalamic neuropeptide Y levels in lean rats 2 days after hypoxia exposure contributed to accounting for the enhanced food consumption. No significant changes occurred in the expression of other hypothalamic neuropeptides involved in the control of food intake. This study demonstrates unequivocally that altitude-induced anorexia cannot be ascribed to anorectic signals triggered by enhanced leptin production or alterations of hypothalamic neuropeptides involved in anabolic or catabolic pathways. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/16234269; inserm-00410553; https://inserm.hal.science/inserm-00410553Test; https://inserm.hal.science/inserm-00410553/documentTest; https://inserm.hal.science/inserm-00410553/file/Simler-06.pdfTest; PUBMED: 16234269 |
| DOI: | 10.1152/ajpendo.00289.2005 |
| الإتاحة: | https://doi.org/10.1152/ajpendo.00289.2005Test https://inserm.hal.science/inserm-00410553Test https://inserm.hal.science/inserm-00410553/documentTest https://inserm.hal.science/inserm-00410553/file/Simler-06.pdfTest |
| رقم الانضمام: | edsbas.E496987E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1152/ajpendo.00289.2005 |
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