المؤلفون: Manon Trinel, Denis Castillo Pareja, Valérie Jullian, Sandra Bourgeade-Delmas, Jeanne Lucas, Christiane André-Barrès

المساهمون: Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Centre National de la Recherche Scientifique (CNRS), Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Institut de Chimie de Toulouse (ICT), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut de Recherche pour le Développement (IRD), Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Planta Medica
Planta Medica, 2021, 87 (03), pp.201-208. ⟨10.1055/a-1298-4706⟩
Planta Medica, Georg Thieme Verlag, 2020, ⟨10.1055/a-1298-4706⟩
Planta Medica, Georg Thieme Verlag, 2021, 87 (03), pp.201-208. ⟨10.1055/a-1298-4706⟩

مصطلحات موضوعية: Plasmodium, Antiparasitic, medicine.drug_class, purl.org/pe-repo/ocde/ford#1.06.03 [https], Plasmodium falciparum, Antiprotozoal Agents, Pharmaceutical Science, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Asteraceae, 010402 general chemistry, 01 natural sciences, Analytical Chemistry, isocedrenes, Perezia multiflora, sesquiterpenes, Drug Discovery, parasitic diseases, medicine, [CHIM]Chemical Sciences, Humans, purl.org/pe-repo/ocde/ford#3.01.05 [https], Leishmania infantum, Malaria, Falciparum, Axenic, Amastigote, IC50, purl.org/pe-repo/ocde/ford#1.04.07 [https], Pharmacology, Leishmania, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, biology.organism_classification, In vitro, 0104 chemical sciences, purl.org/pe-repo/ocde/ford#1.04.01 [https], Complementary and alternative medicine, Biochemistry, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e808fe8ae175c28bdc2b7d9c6127c7Test
https://hal.science/hal-03020846/documentTest

المؤلفون: Joaquina Albán, Mohamed Haddad, Jorge Arevalo, Geneviève Bourdy, Yannick Estevez, Eric Deharo, Rosario Rojas, Ricardo Reategui, Denis Castillo, Michel Sauvain, Candy Ruiz

المصدر: Phytochemistry Letters. 4:363-366

مصطلحات موضوعية: Amide, animal cell, Plant Science, Biochemistry, n 2 (3',4',5' trimethoxyphenyl)ethyl 2 hydroxybenzamide, chemistry.chemical_compound, chalcone derivative, Chalcone, Cytotoxicity, Leishmaniasis, comparative study, Leishmania, Pinocembrin, biology, antiprotozoal activity, article, Piperaceae, amphotericin B, unclassified drug, plant extract, cytotoxicity, antileishmanial agent, Flavanone, Heteronuclear single quantum coherence spectroscopy, pinocembrine, Biotechnology, in vitro study, drug isolation, Piper hispidum, Stereochemistry, non|priority journal, male, controlled study, fractionation, 2',4' dihydroxy 6' methoxychalcone, plant leaf, 2' hydroxy 3',4',6' trimethoxychalcone, Piper, IC 50, biology.organism_classification, nuclear magnetic resonance, drug structure, peritoneum macrophage, chemistry, Heteronuclear molecule, purl.org/pe-repo/ocde/ford#3.01.00 [https], Agronomy and Crop Science, Leishmania amazonensis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c0905a93d8721d1094737d0ad2998bTest
https://doi.org/10.1016/j.phytol.2011.08.001Test

المؤلفون: Jorge Arevalo, Billy Cabanillas, Michel Sauvain, Béatrice Moukarzel, Denis Castillo, Guillaume Odonne, Geneviève Bourdy, Nicolas Fabre, Rosario Rojas, Anne-Cécile Le Lamer

المصدر: Journal of Natural Products. 73:1884-1890

مصطلحات موضوعية: Stereochemistry, Pharmaceutical Science, Biology, Pharmacognosy, Lignans, Analytical Chemistry, Inhibitory Concentration 50, Mice, chemistry.chemical_compound, Caffeic Acids, Chlorocebus aethiops, Peru, Drug Discovery, Caffeic acid, Animals, Amastigote, Nuclear Magnetic Resonance, Biomolecular, Vero Cells, Leishmania, Pharmacology, Lignan, chemistry.chemical_classification, Piper, Cytotoxins, Macrophages, Organic Chemistry, Dioxolanes, Esters, Phenolic acid, Piperaceae, biology.organism_classification, Plant Leaves, Complementary and alternative medicine, chemistry, Molecular Medicine, Female, Drug Screening Assays, Antitumor, Lactone

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac8fc9604c832e6eddeb0f75396ccc6Test
https://doi.org/10.1021/np1005357Test

المؤلفون: Yannick Estevez, Denis Castillo, Eric Deharo, Thomas Grentzinger, German Gonzalez

المصدر: Experimental Parasitology. 122:353-356

مصطلحات موضوعية: Cell Survival, Immunology, Antiprotozoal Agents, Leishmania braziliensis, Monocytes, Microbiology, Inhibitory Concentration 50, Mice, Amphotericin B, Cell Line, Tumor, medicine, Murine macrophages, Animals, Humans, Macrophage, Viability assay, Amastigote, Leishmania peruviana, Leishmania, Leishmanicidal, biology, Kinetoplastida, Leishmaniasis, General Medicine, biology.organism_classification, medicine.disease, Infectious Diseases, Cell culture, Leukemia, Monocytic, Acute, Macrophages, Peritoneal, THP-1, Female, Parasitology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f6dc512cb006c67a7ce6de7f395f06Test
https://doi.org/10.1016/j.exppara.2009.05.005Test

المؤلفون: Denis Castillo, Manu Vanaerschot, Maya Berg, Géraldine De Muylder, Jorge Arevalo, Jean-Claude Dujardin, Bart Cuypers, Marlene Jara, Ilse Maes, María del Carmen Orozco, Guy Caljon

المصدر: PLoS ONE, Vol 12, Iss 7, p e0180532 (2017)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Life Cycles, Adenosine Triphosphate/metabolism, Protozoan Proteins, lcsh:Medicine, Protozoology, Biochemistry, White Blood Cells, chemistry.chemical_compound, Adenosine Triphosphate, Animal Cells, Medicine and Health Sciences, Metabolites, lcsh:Science, Axenic, Cells, Cultured, Protozoan Proteins/analysis/metabolism, Protozoans, Leishmania, Adenosine Diphosphate/metabolism, Mice, Inbred BALB C, Ribosomal Proteins/analysis/metabolism, Multidisciplinary, RNA, Protozoan/analysis/metabolism, biology, Pharmacology. Therapy, Leishmaniasis, Cutaneous/parasitology, Cell biology, Adenosine Diphosphate, Nucleic acids, Ribosomal RNA, Metabolome, Protozoan Life Cycles, Female, Cellular Types, Engineering sciences. Technology, RNA, Protozoan, Intracellular, Research Article, Amastigotes, Ribosomal Proteins, Cellular structures and organelles, Immune Cells, Immunology, Leishmaniasis, Cutaneous, Microbiology, Leishmania braziliensis, 03 medical and health sciences, Biosynthesis, Ribosomal protein, parasitic diseases, Parasitic Diseases, Animals, Non-coding RNA, purl.org/pe-repo/ocde/ford#1.06.01 [https], Amastigote, Biology, Blood Cells, Promastigotes, Macrophages, lcsh:R, Organisms, Biology and Life Sciences, Cell Biology, biology.organism_classification, Parasitic Protozoans, Biosynthetic Pathways, Metabolism, Kinetoplasts, 030104 developmental biology, Leishmania braziliensis/growth & development/metabolism, chemistry, RNA, lcsh:Q, Human medicine, Ribosomes, Developmental Biology

وصف الملف: pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b081b7b39a369f48cd491b77fce57eTest
https://doi.org/10.1371/journal.pone.0180532Test

المؤلفون: Valérie Jullian, Denis Castillo, Michel Sauvain, Marion Rivaud

المساهمون: Universidad Peruana Cayetano Heredia (UPCH), Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)

المصدر: Planta Medica
Planta Medica, 2014, 80 (11), pp.902-906. ⟨10.1055/s-0034-1382826⟩
Planta Medica, Georg Thieme Verlag, 2014, 80 (11), pp.902-906. ⟨10.1055/s-0034-1382826⟩

مصطلحات موضوعية: benzo[c]phenanthridines, Zanthoxylum, Phenanthridines/chemistry/isolation & purification/pharmacology, Plant Extracts/chemistry/isolation & purification/pharmacology, [SDV]Life Sciences [q-bio], Pharmaceutical Science, leishmanicidal, Benzophenanthridines/chemistry/isolation & purification/pharmacology, Plant Bark/chemistry, Plant Roots, Analytical Chemistry, chemistry.chemical_compound, Mice, Macrophages/drug effects, Zanthoxylum rhoifolium, Parasitic Sensitivity Tests, Drug Discovery, Axenic, Leishmaniasis, Leishmania, Mice, Inbred BALB C, biology, in vitro, Benzo[c]phenanthridines, 3. Good health, Phenanthridines, purl.org/pe-repo/ocde/ford#1.04.01 [https], in vivo, Plant Bark, Molecular Medicine, Female, Cell Survival/drug effects, Stereochemistry, Cell Survival, purl.org/pe-repo/ocde/ford#1.06.03 [https], Leishmaniasis, Cutaneous, Inhibitory Concentration 50, Cutaneous leishmaniasis, In vitro, In vivo, medicine, Animals, Humans, purl.org/pe-repo/ocde/ford#3.01.05 [https], Leishmaniasis, Cutaneous/drug therapy/parasitology, Amastigote, purl.org/pe-repo/ocde/ford#1.04.07 [https], leishmaniasis, Rutaceae, Pharmacology, Benzophenanthridines, Plant Roots/chemistry, Plants, Medicinal, Plant Extracts, Macrophages, Organic Chemistry, Leishmania/drug effects, medicine.disease, biology.organism_classification, Molecular biology, Zanthoxylum/chemistry, Disease Models, Animal, Chelerythrine, Complementary and alternative medicine, chemistry, Leishmania amazonensis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed225a60e72e20ee63a518123276bbaaTest
https://pubmed.ncbi.nlm.nih.gov/25029171Test

المؤلفون: Yannick Estevez, Geneviève Bourdy, Céline Valadeau, Rosario Rojas, Anne-Cécile Le Lamer, Denis Castillo, Jorge Arevalo, Michel Sauvain, Nicolas Fabre, Billy Cabanillas

المصدر: Planta medica. 78(9)

مصطلحات موضوعية: Macrophage, Cytotoxicity, Drug Evaluation, Preclinical, Pharmaceutical Science, Benzoates, Dihydrochalcones, Analytical Chemistry, Piper (Plant), chemistry.chemical_compound, Mice, Chalcones, Chalcone Derivative, Drug Discovery, Drug Isolation, Fractionation, Axenic, Spectroscopy, Benzoic acid, Leishmania, Chemical Structure, biology, Molecular Structure, 35 Bis(3 Methyl 2 Butenyl) 4 Methoxybenzoic Acid, Benzoic Acids, Piperaceae, Benzoic Acid, Animal Cell, Molecular Medicine, Bioassay, Drug Evaluation Preclinical, Drug Structure, 4 Hydroxy 35 Bis(3 Methyl 2 Butenyl)Benzoic Acid, Hydroxybenzoate Ethers, 2'6' Dihydroxy 4' Methoxydihydrochalcone, Leishmania Amazonensis, Stereochemistry, Piper Dennisii|Piperaduncin C, Antiprotozoal Agents, Drug Activity, Disease Model, Plant Extract, 4 Hydroxy 3 (3 Methyl 2 Butenoyl) 5 (3 Methyl 2 Butenyl)Benzoic Acid, Inhibitory Concentration 50, Amphotericin B, 3 (3'7' Dimethyl 2'6' Octadienyl) 4 Methoxybenzoic Acid, Animals, Controlled Study, Plant Leaf, Antileishmanial Activities, Amastigote, IC50, Pharmacology, Piper, 22 Dimethyl 8 (3 Methyl 2 Butenyl) 2h 1 Chromene 6 Carboxylic Acid, Antileishmanial Agent, Organic Chemistry, IC 50, biology.organism_classification, Plant Leaves, Macrophages Peritoneal, 42'6' Trihydroxy 4' Methoxydihydrochalcone, Complementary and alternative medicine, chemistry, Macrophages, Peritoneal, purl.org/pe-repo/ocde/ford#3.01.00 [https], Murinae, Benzoic Acid Derivative

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4ea834c7134169119596168d1a5f09Test
https://pubmed.ncbi.nlm.nih.gov/22516933Test

المؤلفون: Gerald B. Hammond, Zhuang Jin, Robert H. Gilman, Denis Castillo, Abraham Vaisberg, Michel Sauvain, Walter H. Lewis, Edith Málaga, José C. Aponte

مصطلحات موضوعية: Male, 10 Acetoxy 89 Dehydro 6 Methoxythymol Butyrate, Compositae, Pharmaceutical Science, Drug Mechanism, Plant Roots, Analytical Chemistry, Trees, Mice, chemistry.chemical_compound, Anti-Infective Agents, Parasitic Sensitivity Tests, Drug Discovery, Peru, Drug Cytotoxicity, Drug Isolation, Axenic, Antileishmania, Thymol, Melanoma, Mikania Decora, Trypanosoma Cruzi, Leishmania, Antineoplastic Activity, Plant Stems, biology, Traditional medicine, Cancer Cell Culture, Lung Cancer, Colon Adenocarcinoma, Cremastosperma Microcarpum Annonaceae, Myeloid Leukemia, Animal Cell, Anticancer, Embryo, Molecular Medicine, Female, Diterpenes, Antiinfective Agent, Acetylschizoginol, Prostate Carcinoma, Cell Survival, Trypanosoma cruzi, Annonaceae, Mikania, Butyrate, Antimicrobial Activity, Lignans, Plant Extract, Cell Line, Tumor, Animals, Humans, Controlled Study, Amastigote, Pharmacology, Cremastosperma microcarpum - Annonaceae, Human Cell, Plant Extracts, Macrophages, 10 Acetoxy 89 Epoxy 6 Methoxythymol Isobutyrate, Organic Chemistry, IC 50, Cell Line Tumor, biology.organism_classification, In vitro, Trypanoside, Plant Leaves, Breast Adenocarcinoma, Complementary and alternative medicine, chemistry, purl.org/pe-repo/ocde/ford#3.01.00 [https], Diterpene

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0108a938a2e950ac6d2150910033f161Test
https://hdl.handle.net/20.500.12866/10921Test

المؤلفون: Edith Málaga, Asunción Burguete, Manuela Verastegui, Eric Deharo, Silvia Pérez-Silanes, Ignacio Aldana, Billy Cabanillas, Yannick Estevez, Antonio Monge, Miguel Quiliano, Denis Castillo, Mirko Zimic

مصطلحات موضوعية: correlation analysis, purl.org/pe-repo/ocde/ford#3.03.07 [https], quinoxaline 1,4 oxide derivative, drug protein binding, trimethoxyphenyl pyrazole quinoxaline, animal cell, Pyrazole, nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase, growth inhibition, chemistry.chemical_compound, Mice, 3 (3,4,5 trimethoxyphenyl) 1 (3,6,7 trimethyl quinoxalin 2 yl)propenone, Chlorocebus aethiops, kidney cell, Polymerase, Leishmania, Mice, Inbred BALB C, biology, Molecular Structure, protozoal protein, antiprotozoal activity, drug cytotoxicity, article, Kinetoplastida, 2,6 dimethyl 3 f quinoxaline 1,4 dioxide, General Medicine, Trypanocidal Agents, amphotericin B, unclassified drug, Infectious Diseases, Biochemistry, antitrypanosomal agent, Female, Intracellular, Trypanosoma cruzi, Immunology, non|priority journal, Cercopithecus aethiops, Structure-Activity Relationship, Quinoxaline, Quinoxalines, parasitic diseases, Structure–activity relationship, Animals, controlled study, drug selectivity, mathematical computing, 1 (7 fluoro 3 methyl quinoxalin 2 yl) 3 (3,4,5 trimethoxyphenyl)propenone, Vero Cells, mouse, Leishmania peruviana, human cell, molecular docking, biology.organism_classification, cell proliferation, peritoneum macrophage, chemistry, Docking (molecular), biology.protein, Macrophages, Peritoneal, drug synthesis, Parasitology, Murinae, computer model, Quinoxaline 1,4-di-N-oxide derivatives, trimethoxyphenyl propenone

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0dd4912940ee737be6ad61cc6ffceaTest
http://www.documentation.ird.fr/hor/fdi:010053425Test

المؤلفون: Denis Castillo, Michel Sauvain, Yannick Estevez, Gerald B. Hammond, Jorge Arevalo, German Gonzalez, José C. Aponte

مصطلحات موضوعية: Chalcone, Clinical Biochemistry, Antiprotozoal Agents, Pharmaceutical Science, Peruviana, Biochemistry, chemistry.chemical_compound, Mice, Chalcones, Parasitic Sensitivity Tests, In vivo, Anti-Leishmanial drugs, Drug Discovery, parasitic diseases, Animals, Axenic, Amastigote, Molecular Biology, Leishmania, Mice, Inbred BALB C, biology, Chemistry, Macrophages, Organic Chemistry, Kinetoplastida, biology.organism_classification, Leishmania braziliensis, In vitro, Braziliensis, Molecular Medicine, Leishmania amazonensis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae5edd6ff3064153df6b54d265e1429Test
http://www.documentation.ird.fr/hor/fdi:010049168Test