رسالة جامعية
維生素D3增補對激烈耐力運動後氧化壓力與肌肉損傷之影響 ; Effects of Vitamin D3 Supplementation on Oxidative Stress and Muscle Damage after Strenuous Endurance Exercise
| العنوان: | 維生素D3增補對激烈耐力運動後氧化壓力與肌肉損傷之影響 ; Effects of Vitamin D3 Supplementation on Oxidative Stress and Muscle Damage after Strenuous Endurance Exercise |
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| المؤلفون: | 楊振澤, YANG, CHENG-TSE |
| المساهمون: | 醫學科學研究所碩士班, 呂思潔 |
| سنة النشر: | 2023 |
| المجموعة: | Taipei Medical University Repository (TMUR) |
| مصطلحات موضوعية: | 硫代巴比妥酸反應物質, 蛋白質羰基, 超氧化離子歧化?, 肌酸激?, 乳酸脫氫?, TBARS, PC, SOD, CK, LDH |
| الوصف: | 碩士 ; 指導教授:呂思潔 ; 委員:呂思潔 ; 委員:楊明達 ; 委員:黃文經 ; 目的：探討四週維生素D3增補對於激烈耐力運動誘發氧化傷害與肌肉損傷之影響。方法：本研究以28名健康男性先於功率腳踏車上進行第一次漸增強度測試至力竭，以測量其最大攝氧量 (V?O2max)，並給予實驗參與者連續四週、每日增補5,000 IU的維生素D3或安慰劑；之後進行第二次漸增強度測試至力竭，以作為兩天後65% V?O2max的激烈耐力運動強度。於四週增補前、後抽血採集靜脈血以測量血清25(OH)D濃度，並於激烈耐力運動前 (Pre)、運動後立即 (Post-0)、運動後2小時 (Post-2)、運動後4小時 (Post-4)、運動後24小時 (Post-24) 採集血液樣本以測量氧化傷害指標 (硫代巴比妥酸反應物質與蛋白質羰基)、抗氧化系統活性 (超氧化離子歧化?、麩胱甘?過氧化?與過氧化氫?) 與肌肉損傷指標 (肌酸激?與乳酸脫氫?)。結果：在四週增補後，維生素D3組之血液維生素D濃度顯著高於增補前與安慰劑組 (p < .05)，且安慰劑組之蛋白質羰基、超氧化離子歧化?與肌酸激?於Post-0、Post-2與Post-24皆顯著高於維生素D3組 (p < .05)，而安慰劑組之硫代巴比妥酸反應物質與乳酸脫氫?於Post-24顯著高於維生素D3組 (p < .05)。另外，安慰劑組之過氧化氫?於Post-0顯著高於維生素D3組 (p < .05)。結論：四週維生素D3增補能夠有效改善激烈耐力運動誘發氧化傷害與肌肉損傷。 ; Purpose: To investigate the effects of vitamin D3 supplementation on strenuous endurance exercise (SEE)-induced oxidative stress and muscle damage. Methods: Twenty-eight male subjects conducted a graded exercise test (GXT) on a cycle ergometer to exhaustion to assess their first maximal oxygen uptake (V?O2max). The participants were instructed to take either a daily dose of 5,000 IU of vitamin D3 or a placebo for a duration of four weeks. After four weeks, all participants completed the second GXT to exhaustion. The V?O2max were used to calculate the intensity of 65% V?O2max for the following SEE. Blood samples were collected before and after four weeks supplementation to determine the concentration of serum 25(OH)D. Additionally, venous blood samples were collected at multiple time points: before SEE (Pre), immediately after (Post-0), 2 hours after (Post-2), 4 hours after (Post-4), and 24 hours after (Post-24). These samples were analyzed to assess markers of oxidative damage (thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PC)), antioxidant system activity (superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT)), as well as muscle damage biomarkers (creatine kinase (CK) and lactate dehydrogenase (LDH)). Results: After four-week supplementation, the serum concentration of 25(OH)D in vitamin D3 group ... |
| نوع الوثيقة: | thesis |
| وصف الملف: | 99 bytes; text/html |
| اللغة: | English |
| العلاقة: | http://libir.tmu.edu.tw/handle/987654321/63330Test; http://libir.tmu.edu.tw/bitstream/987654321/63330/1/index.htmlTest |
| الإتاحة: | http://libir.tmu.edu.tw/handle/987654321/63330Test http://libir.tmu.edu.tw/bitstream/987654321/63330/1/index.htmlTest |
| رقم الانضمام: | edsbas.24C61823 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |