Laboratory parameters related to severe disease and death in SARS‐CoV‐2 pneumonia: Retrospective analysis
| العنوان: | Laboratory parameters related to severe disease and death in SARS‐CoV‐2 pneumonia: Retrospective analysis |
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| المؤلفون: | Stefano Necozione, Gaia Sinatti, Alessandro Grimaldi, Franco Tonello, Vincenza Cofini, Anna Cecilia Carucci, Benedetta Cosimini, Clara Balsano, Paola Vertolli, Giovanna Picchi, Monica Di Norcia |
| المصدر: | Journal of Medical Virology |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Wilcoxon signed-rank test, severe COVID-19, law.invention, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, neutrophil-to-lymphocyte ratio, law, Virology, Internal medicine, medicine, Humans, Medical history, 030212 general & internal medicine, Neutrophil to lymphocyte ratio, Research Articles, Aged, Retrospective Studies, Aged, 80 and over, SARS-CoV-2, business.industry, severe COVID‐19, COVID-19, prognostic factors, Retrospective cohort study, Middle Aged, neutrophil‐to‐lymphocyte ratio, medicine.disease, Respiration, Artificial, Obesity, Intensive care unit, Hospitalization, Patient Outcome Assessment, Intensive Care Units, Exact test, Pneumonia, Infectious Diseases, Italy, laboratory parameters, Female, 030211 gastroenterology & hepatology, business, Research Article |
| الوصف: | The clinical evolution of coronavirus disease 2019 (COVID‐19) is highly variable and hospitalized patients can rapidly develop conditions requiring oxygen support, intensive care unit (ICU) or high dependency unit (HDU) care. Early identification of high‐risk patients is mandatory. We retrospectively collected the medical history, symptoms, radiological, and laboratory findings of COVID‐19 patients hospitalized between February and April 2020. Laboratory data were collected at the first, last, and middle times of hospitalization. We used arterial oxygen partial pressure and fractional inspired oxygen ratio (P/F) to evaluate respiratory status. Outcomes considered were death and ICU/HDU admission. We used the χ 2 or Fisher's exact test to examine differences between categorical variables. Continuous variables were analyzed using the Wilcoxon matched pairs signed‐ranks test and Mann–Whitney test sample test. Of 71 patients admitted, 92% had interstitial pneumonia, and 17% an unfavorable outcome. Negative predictors were age, cerebrovascular disease, obesity, and chronic obstructive pulmonary disease. Baseline P/F was strongly associated with all outcomes. Markers linked to immunological dysregulation like elevated neutrophil‐to‐lymphocyte ratio exhibited prognostic significance over time. A validated prognostic score comprehensive of all these conditions for early staging and management of COVID‐19 patients is urgently needed. Further studies are desirable to evaluate whether laboratory tests can target early treatment in high‐risk patients. |
| تدمد: | 1096-9071 0146-6615 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69402ef4d8195afb4f13dabf342d0cbfTest https://doi.org/10.1002/jmv.27141Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....69402ef4d8195afb4f13dabf342d0cbf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969071 01466615 |
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