التفاصيل البيبلوغرافية
| العنوان: |
Long-term neuropsychological outcomes of survivors of young childhood brain tumors treated on the Head Start II protocol. |
| المؤلفون: |
Levitch, Cara F, Malkin, Benjamin, Latella, Lauren, Guerry, Whitney, Gardner, Sharon L, Finlay, Jonathan L, Sands, Stephen A |
| المصدر: |
Neuro-Oncology Practice; Oct2021, Vol. 8 Issue 5, p609-619, 11p |
| مصطلحات موضوعية: |
BRAIN tumors, HEAD tumors, HEMATOPOIETIC stem cell transplantation, ARITHMETIC mean, DIAGNOSIS, EXTERNALIZING behavior, VERBAL learning |
| مستخلص: |
Background The Head Start treatment protocols have focused on curing young children with brain tumors while avoiding or delaying radiotherapy through using a combination of high-dose, marrow-ablative chemotherapy and autologous hematopoietic cell transplantation (AuHCT). Late effects data from treatment on the Head Start II (HS II) protocol have previously been published for short-term follow-up (STF) at a mean of 39.7 months post-diagnosis. The current study examines long-term follow-up (LTF) outcomes from the same cohort. Methods Eighteen HS II patients diagnosed with malignant brain tumors <10 years of age at diagnosis completed a neurocognitive battery and parents completed psychological questionnaires at a mean of 104.7 months' post-diagnosis. Results There was no significant change in Full Scale IQ at LTF compared to baseline or STF. Similarly, most domains had no significant change from STF, including verbal IQ, performance IQ, academics, receptive language, learning/memory, visual-motor integration, and externalizing behaviors. Internalizing behaviors increased slightly at LTF. Clinically, most domains were within the average range, except for low average mathematics and receptive language. Additionally, performance did not significantly differ by age at diagnosis or time since diagnosis. Of note, children treated with high-dose methotrexate for disseminated disease or atypical teratoid/rhabdoid tumor displayed worse neurocognitive outcomes. Conclusions These results extend prior findings of relative stability in intellectual functioning for a LTF period. Ultimately, this study supports that treatment strategies for avoiding or delaying radiotherapy using high-dose, marrow-ablative chemotherapy and AuHCT may decrease the risk of neurocognitive and social-emotional declines in young pediatric brain tumor survivors. [ABSTRACT FROM AUTHOR] |
|
Copyright of Neuro-Oncology Practice is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder