التفاصيل البيبلوغرافية
| العنوان: |
Frailty repels the knife: The impact of frailty index on surgical intervention and outcomes. |
| المؤلفون: |
Handley, Katelyn F.1,2,3 (AUTHOR), Sood, Anil K.1 (AUTHOR), Molin, Graziela Zibetti Dal4 (AUTHOR), Westin, Shannon N.1 (AUTHOR), Meyer, Larissa A.1 (AUTHOR), Fellman, Bryan5 (AUTHOR), Soliman, Pamela T.1 (AUTHOR), Coleman, Robert L.6 (AUTHOR), Fleming, Nicole D.1 (AUTHOR) nfleming@mdanderson.org |
| المصدر: |
Gynecologic Oncology. Jul2022, Vol. 166 Issue 1, p50-56. 7p. |
| مصطلحات موضوعية: |
*FRAILTY, *SPLENECTOMY, *PROGRESSION-free survival, *PATIENT decision making, *LAPAROSCOPIC surgery, TUMOR surgery |
| مستخلص: |
To assess the impact of frailty in patients with ovarian cancer on surgical procedures and outcomes. A retrospective review of patients with stage II-IV ovarian cancer from April 2013 to September 2017 was performed. Patients were triaged by laparoscopy to determine primary resectability. The adjusted modified frailty index score (amFI) was calculated and amFI ≥2 classified as high frailty. Clinical outcomes, progression free survival (PFS) and overall survival (OS) were estimated. 592 patients met inclusion criteria; amFI of 0, 1 and ≥ 2 was noted in 57%, 29%, and 14%, respectively. Patients with high frailty were less likely to be offered laparoscopic assessment for primary surgery (49% v. 43% v. 28% for amFI = 0, 1, and ≥ 2, p = 0.004), and more likely to have a Fagotti score ≥ 8 (58%, 48%, and 34%, p = 0.04). Only 17% of the high frailty cohort had primary tumor reductive surgery compared to 26% and 34% in patients with amFI = 1 and amFI = 0 (p = 0.02). Furthermore, patients with higher amFI were less likely to undergo any tumor reductive surgery (85% v. 74% v. 59%, p < 0.001). Postoperative complications were more frequent in patients with higher amFI (44% v. 56% v. 64%, p = 0.01). Death within thirty days of treatment initiation was significantly higher in patients with high frailty (0.4% v. 2% v. 9%, p = 0.005). In multivariate analysis, high frailty was associated with worse PFS (p = 0.02) and OS (p < 0.05). Postoperative morbidity, PFS, and OS were worse in patients with high frailty scores. Quantification of frailty may be useful for clinical decision making in patients with newly diagnosed advanced ovarian cancer. • Patients with high frailty were less likely to be offered a laparoscopic surgery to determine primary resectability. • If laparoscopy was performed, the PIV was more likely to be ≥8 in patients with a higher frailty score. • Patients with a higher frailty score were less likely to undergo any tumor reductive surgery, primary or interval. • Patients with high frailty were more likely to undergo splenectomy and small bowel resection. • Postoperative complications, PFS, and OSwere significantly worse in patients with higher amFI. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
