التفاصيل البيبلوغرافية
| العنوان: |
Synthesis and antihyperlipidemic activity of Dibenz[c,e]azepine-5,7-dione derivatives in Triton WR-1339-induced hyperlipidemic rats. |
| المؤلفون: |
Verma, Minakshi, Gupta, Ashish Kumar, Thakur, Ravindra Nath |
| المصدر: |
Journal of Drug Delivery & Therapeutics; Mar-Apr2018, Vol. 8 Issue 2, p129-135, 7p |
| مصطلحات موضوعية: |
DRUG synthesis, DIBENZYL ketone, HYPERLIPIDEMIA treatment, CHEMICAL derivatives, LABORATORY rats |
| مستخلص: |
The structural requirements for decreasing cholesterol and triglyceride levels remain largely uninvestigated. Thus a systematic investigation of certain N-substituted dibenz[c,e]azepines is necessary. Nine compounds of N-substituted derivatives of Dibenz[c,e]azepine-5,7-Dione were synthesized and they were tested for antihyperlipidemic activity. Compounds synthesized (C-1, C-3, C-4 and C-5) significantly lowered the serum total cholesterol, triglyceride and LDL (low density lipoprotein) levels and also improved the HDL (high density lipoprotein) level in Triton-WR 1339 induced hyperlipidemic rats. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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