دورية أكاديمية
Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction
| العنوان: | Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction |
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| المؤلفون: | Sugihara, Kohei, Kitamoto, Sho, Saraithong, Prakaimuk, Nagao-Kitamoto, Hiroko, Hoostal, Matthew, Mccarthy, Caroline, Rosevelt, Alexandra, Muraleedharan, Chithra, Gillilland, Merritt, Imai, Jin, Omi, Maiko, Bishu, Shrinivas, Kao, John, Alteri, Christopher, Barnich, Nicolas, Schmidt, Thomas, Nusrat, Asma, Inohara, Naohiro, Golob, Jonathan, Kamada, Nobuhiko |
| المساهمون: | University of Michigan Ann Arbor, University of Michigan System, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Osaka University Osaka |
| المصدر: | ISSN: 2211-1247. |
| بيانات النشر: | HAL CCSD Elsevier Inc |
| سنة النشر: | 2022 |
| المجموعة: | Institut National de la Recherche Agronomique: ProdINRA |
| مصطلحات موضوعية: | Akkermansia muciniphila, CP: Microbiology, L-serine, adherent-invasive Escherichia coli, inflammatory bowel disease, intestinal mucus barrier, [SDV.BC]Life Sciences [q-bio]/Cellular Biology |
| الوصف: | International audience ; Pathobionts employ unique metabolic adaptation mechanisms to maximize their growth in disease condi-tions. Adherent-invasive Escherichia coli (AIEC), a pathobiont enriched in the gut mucosa of patients with inflammatory bowel disease (IBD), utilizes diet-derived L-serine to adapt to the inflamed gut. Therefore, the restriction of dietary L-serine starves AIEC and limits its fitness advantage. Here, we find that AIEC can overcome this nutrient limitation by switching the nutrient source from the diet to the host cells in the pres-ence of mucolytic bacteria. During diet-derived L-serine restriction, the mucolytic symbiont Akkermansia muciniphila promotes the encroachment of AIEC to the epithelial niche by degrading the mucus layer. In the epithelial niche, AIEC acquires L-serine from the colonic epithelium and thus proliferates. Our work sug-gests that the indirect metabolic network between pathobionts and commensal symbionts enables patho-bionts to overcome nutritional restriction and thrive in the gut. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35858565; hal-03907428; https://hal.inrae.fr/hal-03907428Test; https://hal.inrae.fr/hal-03907428/documentTest; https://hal.inrae.fr/hal-03907428/file/2022_Sugihara_Cell%20Reports.pdfTest; PUBMED: 35858565; WOS: 000842466000005 |
| DOI: | 10.1016/j.celrep.2022.111093 |
| الإتاحة: | https://doi.org/10.1016/j.celrep.2022.111093Test https://hal.inrae.fr/hal-03907428Test https://hal.inrae.fr/hal-03907428/documentTest https://hal.inrae.fr/hal-03907428/file/2022_Sugihara_Cell%20Reports.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.61514F02 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2022.111093 |
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