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1دورية أكاديمية
المؤلفون: Filipe B Rodrigues, Lauren M Byrne, Alexander J Lowe, Rosanna Tortelli, Mariette Heins, Gunnar Flik, Eileanoir B Johnson, Enrico De Vita, Rachael I Scahill, Flaviano Giorgini, Edward J Wild
مصطلحات موضوعية: Uncategorized, Biomarkers, Blood, Cerebrospinal Fluid, Cohort Studies, Huntington Disease, Kynurenine
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المؤلفون: E. De Vita, Rachael I. Scahill, Filipe B. Rodrigues, R. Tortelli, Mariette Heins, Gunnar Flik, A. J. Lowe, Lauren M. Byrne, Flaviano Giorgini, Eileanoir B. Johnson, Edward J. Wild
المصدر: Journal of Neurochemistry
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Kynurenine pathway, Pharmacology, Biochemistry, cerebrospinal fluid, Cohort Studies, Pathogenesis, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Kynurenic acid, Cerebrospinal fluid, Huntington's disease, blood, medicine, Humans, Prospective Studies, Kynurenine, Chromatography, High Pressure Liquid, Aged, business.industry, Clinical Studies, Biomakers & Imaging, biomarkers, Human brain, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Huntington Disease, Phenotype, 030104 developmental biology, medicine.anatomical_structure, chemistry, Original Article, Female, ORIGINAL ARTICLES, business, 030217 neurology & neurosurgery, Signal Transduction, Quinolinic acid
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf51725f7f138eabd61f8be52c8ce9Test
https://doi.org/10.1111/jnc.15360Test -
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المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)مصطلحات موضوعية: Male, medicine.medical_specialty, Kynurenine pathway, Science, Neuroimmunology, Neuroprotection, Article, Mice, chemistry.chemical_compound, Kynurenine 3-Monooxygenase, Kynurenic acid, Huntington's disease, Internal medicine, medicine, Animals, Inflammation, Mice, Knockout, Multidisciplinary, business.industry, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, Huntington Disease, Endocrinology, chemistry, Knockout mouse, Medicine, Cytokines, Diseases of the nervous system, Female, business, Gene Deletion, Kynurenine, Neuroscience
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa9f8f3cf2364e41de33a65ab1e61b0Test
http://europepmc.org/articles/PMC7943810Test -
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المؤلفون: Mary E.W. Collier, Shaowei Zhang, Nigel S. Scrutton, Flaviano Giorgini
المصدر: Drug Discovery Today
Collier, M E W, Zhang, S, Scrutton, N & Giorgini, F 2021, ' Inflammation control and improvement of cognitive function in COVID-19 infections: Is there a role for kynurenine 3-monooxygenase inhibition? ', Drug discovery today . https://doi.org/10.1016/j.drudis.2021.02.009Testمصطلحات موضوعية: 0301 basic medicine, Nervous system, Kynurenine pathway, Inflammation, Review, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, Cognition, Kynurenine 3-Monooxygenase, Drug Discovery, medicine, Animals, Humans, Kynurenine, Pharmacology, Sulfonamides, Post-Green, business.industry, Tryptophan, COVID-19, Metabolic pathway, Thiazoles, 030104 developmental biology, medicine.anatomical_structure, Neuroprotective Agents, chemistry, 030220 oncology & carcinogenesis, Immunology, Respiratory virus, medicine.symptom, business, Signal Transduction
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9a6c7e6f3e021b6ffb5f3109bc206aTest
http://europepmc.org/articles/PMC7889466Test -
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المؤلفون: Shaowei Zhang, Robert Schwarcz, Derren J. Heyes, Carlo Breda, Christopher David Edlin, Flaviano Giorgini, Nigel S. Scrutton, Girdhar Singh Deora, Colin Levy, Kevin D. Read, Marina Wright Muelas, Douglas B. Kell, David Leys, Benjamin P. Ross, Philip J. R. Day, Alex D Klausing, Stephen O’Hagan, Michiyo Sakuma
المصدر: Communications Biology, Vol 2, Iss 1, Pp 1-10 (2019)
Zhang, S, Sakuma, M, Deora, G S, Levy, C, Klausing, A, Breda, C, Read, K D, Ross, B P, Wright Muelas, M, Day, P, O'Hagan, S, Kell, D, Schwarcz, R, Leys, D, Heyes, D, Giorgini, F & Scrutton, N 2019, ' A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites ', Communications Biology . https://doi.org/10.1038/s42003-019-0520-5Test
Communications Biology
COMMUNICATIONS BIOLOGYمصطلحات موضوعية: Kynurenine pathway, Metabolite, Medicine (miscellaneous), Pharmacology, Neuroprotection, Article, General Biochemistry, Genetics and Molecular Biology, Pathogenesis, Mice, 03 medical and health sciences, chemistry.chemical_compound, Kynurenine 3-Monooxygenase, 0302 clinical medicine, Manchester Institute of Biotechnology, medicine, Animals, Neurodegeneration, Enzyme Inhibitors, lcsh:QH301-705.5, X-ray crystallography, 030304 developmental biology, 0303 health sciences, Drug discovery, business.industry, Brain, Neurodegenerative Diseases, Hydrogen Peroxide, Prodrug, medicine.disease, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, Chemical biology, 3. Good health, chemistry, lcsh:Biology (General), Blood-Brain Barrier, General Agricultural and Biological Sciences, business, 030217 neurology & neurosurgery, Kynurenine
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cef15ca27e150c8aaa51693da774887Test
http://link.springer.com/article/10.1038/s42003-019-0520-5Test -
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المؤلفون: Flaviano Giorgini, Aisha M. Swaih, Anna Straatman-Iwanowska, Charalambos P. Kyriacou, Daniel C. Maddison, Mónica Alfonso-Núñez, Susanna Campesan, Natalie Allcock, Carlo Breda
المصدر: PLoS Genetics
PLoS Genetics, Vol 16, Iss 11, p e1009129 (2020)مصطلحات موضوعية: Male, Cancer Research, Kynurenine pathway, Physiology, QH426-470, Mitochondrion, Biochemistry, Mitochondrial Dynamics, Parkin, Animals, Genetically Modified, chemistry.chemical_compound, 0302 clinical medicine, RNA interference, Mitophagy, Drosophila Proteins, Post-Translational Modification, Phosphorylation, Kynurenine 3-Monooxygenase, Genetics (clinical), Energy-Producing Organelles, Kynurenine, 0303 health sciences, Drosophila Melanogaster, Eukaryota, Gene Expression Regulation, Developmental, Animal Models, Climbing, Cell biology, Mitochondria, Up-Regulation, Insects, Nucleic acids, Phenotypes, Experimental Organism Systems, Genetic interference, Gene Knockdown Techniques, 293T cells, Hyperexpression Techniques, Cell lines, Mitochondrial fission, Drosophila, Epigenetics, Cellular Structures and Organelles, Biological cultures, Research Article, Dynamins, Arthropoda, Ubiquitin-Protein Ligases, PINK1, Biology, Bioenergetics, Protein Serine-Threonine Kinases, Research and Analysis Methods, 03 medical and health sciences, Model Organisms, Genetics, Gene Expression and Vector Techniques, Animals, Humans, Molecular Biology Techniques, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Alleles, 030304 developmental biology, Molecular Biology Assays and Analysis Techniques, Biological Locomotion, Organisms, Biology and Life Sciences, Proteins, Epistasis, Genetic, Cell Biology, Invertebrates, HEK293 Cells, chemistry, Mutation, Animal Studies, RNA, Gene expression, Zoology, Entomology, Protein Processing, Post-Translational, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd690b874d8039bfeb5a7717f001153Test
http://europepmc.org/articles/PMC7654755Test -
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المؤلفون: Flaviano Giorgini, Paul J. Muchowski, Marian A. R. Thomas, Sophie Imbeault, Robert Schwarcz, Xi-Cong Liu, Daniel C. Maddison, Ana Pocivavsek, Mariaelena Repici, Joshua L. Smalley, Sophie Erhardt, Markus K. Larsson
المصدر: Biological Psychiatry. 82:756-765
مصطلحات موضوعية: 0301 basic medicine, Elevated plus maze, medicine.medical_specialty, Dextroamphetamine, Central nervous system, Motor Activity, Kynurenic Acid, Article, Open field, Mice, 03 medical and health sciences, chemistry.chemical_compound, Kynurenine 3-Monooxygenase, 0302 clinical medicine, Kynurenic acid, Cerebellum, Internal medicine, medicine, Animals, Biological Psychiatry, Cerebral Cortex, Mice, Knockout, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Nicotinic agonist, Psychotic Disorders, chemistry, Knockout mouse, Schizophrenia, Schizophrenic Psychology, Psychology, Neuroscience, 030217 neurology & neurosurgery, Kynurenine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907d9f091ca59e1c44786aa315623ac2Test
https://doi.org/10.1016/j.biopsych.2016.12.011Test -
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المؤلفون: Flaviano Giorgini, Robert Schwarcz, Sarah Beggiato, Korrapati V. Sathyasaikumar, Francesca M. Notarangelo
المصدر: Journal of psychopharmacology (Oxford, England). 32(11)
مصطلحات موضوعية: medicine.medical_specialty, Genotype, Placenta, macromolecular substances, Kynurenic Acid, Fetal brain, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Kynurenic acid, Kynurenine 3-Monooxygenase, Pregnancy, Internal medicine, medicine, Animals, Pharmacology (medical), Cognitive Dysfunction, Kynurenine, Pharmacology, Mice, Knockout, business.industry, Tryptophan, Brain, Quinolinic Acid, medicine.disease, Pathophysiology, 030227 psychiatry, Mice, Inbred C57BL, Psychiatry and Mental health, Tryptophan Metabolite, Endocrinology, chemistry, Schizophrenia, Female, business, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab4dd9bbe1621c24cf887b739405b7eTest
https://pubmed.ncbi.nlm.nih.gov/30354938Test -
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المؤلفون: Flaviano Giorgini, Mariaelena Repici, Aisha M. Swaih, Carlo Breda
المصدر: Pathogenic mechanisms.
مصطلحات موضوعية: chemistry.chemical_compound, Transmembrane domain, Bimolecular fluorescence complementation, Kynurenine pathway, Huntingtin, chemistry, mental disorders, Mitochondrion, Kynurenine 3-Monooxygenase, Kynurenine, Quinolinic acid, Cell biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4c5f059401e8ad746866c231313e8995Test
https://doi.org/10.1136/jnnp-2018-ehdn.27Test -
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المصدر: Methods in molecular biology (Clifton, N.J.). 1780
مصطلحات موضوعية: Male, Huntingtin Protein, Tryptophan, Brain, Middle Aged, Disease Models, Animal, Huntington Disease, Kynurenine 3-Monooxygenase, Neuroprotective Agents, Animals, Humans, Female, Enzyme Inhibitors, Kynurenine, Metabolic Networks and Pathways, Aged
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::8371fc25c566618f1f1a63f08a571b09Test
https://pubmed.ncbi.nlm.nih.gov/29856028Test
