دورية أكاديمية
'Kiss-and-Run' exocytosis in astrocytes
| العنوان: | 'Kiss-and-Run' exocytosis in astrocytes |
|---|---|
| المؤلفون: | Chen, Xiao-Ke, Xiong, Ying-Fei, Zhou, Zhuan |
| المساهمون: | Zhou, Z (reprint author), Peking Univ, Inst Mol Med, 5 Yi He Yuan Rd, Beijing 100871, Peoples R China., Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China., Peking Univ, Coll Life Sci, State Key Lab Biomembrane Engn, Beijing 100871, Peoples R China., Fourth Mil Med Univ, Inst Neurosci, Xian 710032, Peoples R China., Peking Univ, Inst Mol Med, 5 Yi He Yuan Rd, Beijing 100871, Peoples R China. |
| المصدر: | PubMed ; SCI |
| بيانات النشر: | neuroscientist |
| سنة النشر: | 2006 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | kiss-and-run, fusion pore, amperometry, glutamate, astrocyte, ADRENAL CHROMAFFIN CELLS, DEPENDENT GLUTAMATE RELEASE, SINGLE SYNAPTIC VESICLES, CALCIUM OSCILLATIONS, TRANSMITTER RELEASE, QUANTAL SECRETION, MEMBRANE-FUSION, GROWTH CONES, IN-SITU, NEURONS |
| الوصف: | Neurons and glia are the principal cellular components of the nervous system. Although the glia are 10 times more numerous than neurons, until recently they were thought to be passive cells that monitor and support the active neurons by taking up used neurotransmitters from the synapses. In the past few years, this concept has been challenged by the findings that Ca2+ waves spread from one astrocyte to another via Ca2+- and SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor)-dependent gliotransmitter release in pure cultures of astrocytes, raising the possibility that glia are not so passive as previously thought. This hypothesis was further advanced by two recent reports, which demonstrated that astrocytes release glutamate via vesicular exocytosis in response to stimuli. The kinetics of single vesicle exocytosis is distinct from its neural equivalent, because in response to physiological stimulation, gliotransmitter release is exclusively in the mode of "kiss and run." These advances were made possible by newly available techniques for single vesicle recordings, which will also be briefly reviewed here. ; Clinical Neurology ; Neurosciences ; SCI(E) ; PubMed ; 5 ; ARTICLE ; 5 ; 375-378 ; 12 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1073-8584 |
| العلاقة: | NEUROSCIENTIST.2006,12,(5),375-378.; 674518; http://hdl.handle.net/20.500.11897/345765Test; WOS:000240679400009 |
| DOI: | 10.1177/1073858406291588 |
| الإتاحة: | https://doi.org/20.500.11897/345765Test https://doi.org/10.1177/1073858406291588Test https://hdl.handle.net/20.500.11897/345765Test |
| رقم الانضمام: | edsbas.1055632D |
| قاعدة البيانات: | BASE |
| تدمد: | 10738584 |
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| DOI: | 10.1177/1073858406291588 |