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1
المؤلفون: Karen Collins, Donald Wojciechowicz, Judy Lucas, Nancy Torres, Jeremy I. Levin, Yongbo Hu, Cilien Hanna, Dan M. Berger, Edward J. Salaski, Eileen Frommer, Minu Dutia, Wang Xiaolun, Dennis Powell
المصدر: Journal of Medicinal Chemistry. 53:7874-7878
مصطلحات موضوعية: Models, Molecular, Proto-Oncogene Proteins B-raf, Indazoles, Transplantation, Heterologous, Mutant, Antineoplastic Agents, Pharmacology, Mice, Structure-Activity Relationship, Pyrimidine analogue, chemistry.chemical_compound, Pharmacokinetics, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Chemistry, Kinase, Bridged Bicyclo Compounds, Heterocyclic, humanities, Pyrimidines, Biochemistry, Mutation, Pyrazoles, Molecular Medicine, Drug Screening Assays, Antitumor, Selectivity, Lead compound, Neoplasm Transplantation
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cfb7f80cde520202634116ccfc59adTest
https://doi.org/10.1021/jm1007566Test -
2
المؤلفون: Yongbo Hu, Karen Collins, Edward J. Salaski, Nancy Torres, Eileen Frommer, Dennis Powell, Wang Xiaolun, Jeremy I. Levin, Donald Wojciechowicz, Dan Maarten Berger
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6571-6574
مصطلحات موضوعية: Models, Molecular, Proto-Oncogene Proteins B-raf, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Substrate Specificity, Structure-Activity Relationship, Pyrimidine analogue, Drug Discovery, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Kinase, Organic Chemistry, In vitro, Pyrimidines, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Pyrazoles, Molecular Medicine, Signal transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981acddc510eaf8186f924c43131f046Test
https://doi.org/10.1016/j.bmcl.2009.10.030Test -
3
المؤلفون: Steven C. Kim, Frederick Lee, Eileen Frommer, Mengxiao Shi, Yongbo Hu, Donald Wojciechowicz, Robert Mallon, Greg Ciszewski, Dan Maarten Berger, Karen Collins, Ariamala Gopalsamy, Larry Feldberg
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6890-6892
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Pyrimidine, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Carboxamide, Biochemistry, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Kinase, Organic Chemistry, Hit to lead, Pyrimidines, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Pyrazoles, Molecular Medicine, Signal transduction, Lead compound
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6af29a6344c217dfecdc0daf235230Test
https://doi.org/10.1016/j.bmcl.2009.10.074Test -
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المؤلفون: Edward J. Salaski, Wang Xiaolun, Dennis Powell, Donald Wojciechowicz, Eileen Frommer, Dan M. Berger, Karen Collins, Yongbo Hu
المصدر: Bioorganicmedicinal chemistry letters. 21(23)
مصطلحات موضوعية: Models, Molecular, Niacinamide, Proto-Oncogene Proteins B-raf, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Isoindoles, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Potency, Enzyme Inhibitors, Molecular Biology, Molecular Structure, Chemistry, Kinase, Phenylurea Compounds, Organic Chemistry, Benzenesulfonates, Imidazoles, Isoindoline, Sorafenib, Combinatorial chemistry, Enzyme Activation, Drug Design, Molecular Medicine, Structure based, Phthalazines, Selectivity
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2b84f81a40df7101d2b4f6a8635c87Test
https://pubmed.ncbi.nlm.nih.gov/22024030Test -
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المؤلفون: Mengxiao Shi, Larry Feldberg, Frederick Lee, Yongbo Hu, Donald Wojciechowicz, Ariamala Gopalsamy, Steven C. Kim, Karen Collins, Robert Mallon, Eileen Frommer
المصدر: Bioorganicmedicinal chemistry letters. 20(8)
مصطلحات موضوعية: chemistry.chemical_classification, Models, Molecular, Proto-Oncogene Proteins B-raf, Scaffold, Thienopyridine, Pyrimidine, Kinase, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Combinatorial chemistry, chemistry.chemical_compound, Structure-Activity Relationship, Enzyme, Pyrimidines, chemistry, Drug Discovery, Molecular Medicine, Pharmacophore, Molecular Biology, Lead compound, Cell potency, Protein Kinase Inhibitors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217a9762ff7cb7662f0b9e91c001712cTest
https://pubmed.ncbi.nlm.nih.gov/20307980Test -
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المؤلفون: Frederick Lee, Ariamala Gopalsamy, Yongbo Hu, Greg Ciszewski, Donald Wojciechowicz, Karen Collins, Steven C. Kim, Larry Feldberg, Eileen Frommer, Robert Mallon
المصدر: ChemInform. 40
مصطلحات موضوعية: chemistry.chemical_compound, Pyrimidine, Chemistry, Colorectal cancer, Kinase, Cancer research, medicine, Identification (biology), Raf kinase, General Medicine, Signal transduction, medicine.disease, Small molecule
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5d68a32fa0b4a6cf2b9d5f0e9b5fa80aTest
https://doi.org/10.1002/chin.200940153Test -
7
المؤلفون: Steven C. Kim, Yongbo Hu, Nancy Torres, Dan Maarten Berger, Ariamala Gopalsamy, Kyung-Hee Kim, Weixin Xu, Donald Wojciechowicz, Larry Feldberg, Jeremy I. Levin, Dennis Powell, James M. Wilhelm, Greg Ciszewski, Eileen Frommer, Karen Collins, Minu Dutia, Robert Mallon
المصدر: Bioorganicmedicinal chemistry letters. 19(23)
مصطلحات موضوعية: Models, Molecular, Proto-Oncogene Proteins B-raf, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Transferase, Structure–activity relationship, Molecular Biology, Protein Kinase Inhibitors, Trifluoromethyl, Molecular Structure, Kinase, Chemistry, Aryl, Organic Chemistry, Stereoisomerism, Pyrimidines, Benzamides, Molecular Medicine, Pyrazoles
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c93c7ce2c3fcc01d9a845c40838c5cTest
https://pubmed.ncbi.nlm.nih.gov/19864136Test -
8
المؤلفون: Karen Collins, Steven C. Kim, Donald Wojciechowicz, Larry Feldberg, Frederick Lee, Eileen Frommer, Yongbo Hu, Robert Mallon, Ariamala Gopalsamy, Greg Ciszewski
المصدر: Bioorganicmedicinal chemistry letters. 19(10)
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Pyrimidine, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, medicine, Humans, Computer Simulation, Molecular Biology, Protein Kinase Inhibitors, chemistry.chemical_classification, biology, Kinase, Organic Chemistry, Small molecule, In vitro, Enzyme, Pyrimidines, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Signal transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8e36f6b9ef3c487a3b1c921c05d988Test
https://pubmed.ncbi.nlm.nih.gov/19362830Test -
9
المؤلفون: Wang Xiaolun, Levin I. Jeremy, Nancy Torres, Donald Wojciechowicz, Edward J. Salaski, Yongbo Hu, Eileen Frommer, Dan Maarten Berger, Dennis Powell, Karen Collins
المصدر: Molecular Cancer Therapeutics. 8:A85-A85
مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, Kinase, Cell, Wild type, Biology, Serine, Enzyme, medicine.anatomical_structure, Oncology, Biochemistry, chemistry, Cell culture, medicine, Signal transduction, Protein kinase A
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::524814e839cb0deb10ba60886cd95053Test
https://doi.org/10.1158/1535-7163.targ-09-a85Test